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Results for “Heterozygous Familial Hypercholesterolemia (HeFH)”

40 trials

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Showing 20 of 40 results

Very early researchNot Yet RecruitingNCT07353398
What this trial is testing

Early-phase Study of ART002g1 Injection in HeFH: Safety, Tolerability and Preliminary Efficacy

Who this might be right for
Heterozygous Familial Hypercholesterolemia
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 24
Large-scale testing (Phase 3)Study completedNCT03814187
What this trial is testing

Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C

Who this might be right for
ASCVDElevated CholesterolHeterozygous Familial Hypercholesterolemia+1 more
Novartis Pharmaceuticals 3,275
Large-scale testing (Phase 3)Active Not RecruitingNCT07000136
What this trial is testing

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFH

Who this might be right for
Heterozygous Familial Hypercholesterolaemia
AstraZeneca 473
Large-scale testing (Phase 3)Study completedNCT02624869
What this trial is testing

Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)

Who this might be right for
Familial Hypercholesterolemia
Amgen 163
Large-scale testing (Phase 3)Ended earlyNCT00384293
What this trial is testing

Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED)

Who this might be right for
Hypercholesterolemia, Familial
Merck Sharp & Dohme LLC 937
Testing effectiveness (Phase 2)Study completedNCT01266876
What this trial is testing

Study of the Safety and Efficacy of REGN727/SAR236553 in Patients With HeFH Hypercholesterolemia

Who this might be right for
Hypercholesterolemia
Regeneron Pharmaceuticals 77
Large-scale testing (Phase 3)Study completedNCT03067441
What this trial is testing

Assessment of the Long-Term Safety and Efficacy of Bempedoic Acid (CLEAR Harmony OLE)

Who this might be right for
HypercholesterolemiaAtherosclerotic Cardiovascular Disease
Esperion Therapeutics, Inc. 1,462
Large-scale testing (Phase 3)Study completedNCT02666664
What this trial is testing

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)

Who this might be right for
HypercholesterolemiaAtherosclerotic Cardiovascular Diseases
Esperion Therapeutics, Inc. 2,230
Large-scale testing (Phase 3)Study completedNCT05425745
What this trial is testing

Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.

Who this might be right for
DyslipidemiasHigh CholesterolHypercholesterolemia+6 more
NewAmsterdam Pharma 354
Large-scale testing (Phase 3)Study completedNCT00694109
What this trial is testing

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Who this might be right for
Lipid Metabolism, Inborn ErrorsHypercholesterolemia, Autosomal DominantHyperlipidemias+11 more
Kastle Therapeutics, LLC 144
Large-scale testing (Phase 3)Not Yet RecruitingNCT07450378
What this trial is testing

QLC7401 in Participants With Heterozygous Familial Hypercholesterolemia (HeFH)

Who this might be right for
Heterozygous Familial Hypercholesterolemia (HeFH)
Qilu Pharmaceutical Co., Ltd. 120
Large-scale testing (Phase 3)Study completedNCT03337308
What this trial is testing

A Study Evaluating the Safety and Efficacy of Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared to Bempedoic Acid, Ezetimibe, and Placebo in Patients Treated With Maximally Tolerated Statin Therapy

Who this might be right for
Hyperlipidemias
Esperion Therapeutics, Inc. 382
Not applicableNot Yet RecruitingNCT07427472
What this trial is testing

"Detection and Follow-up of Coronary Lesions in HeFH (DESTINY-FH Study)"

Who this might be right for
Heterozygous Familial Hypercholesterolemia (HeFH)
Assistance Publique - Hôpitaux de Paris 300
Large-scale testing (Phase 3)Study completedNCT05325203
What this trial is testing

Evaluate the Efficacy and Safety of JS002 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH).

Who this might be right for
Heterozygous Familial Hypercholesterolemia
Shanghai Junshi Bioscience Co., Ltd. 135
Not applicableLooking for participantsNCT07470723
What this trial is testing

The ORIGIN-FH Study

Who this might be right for
Heterozygous Familial Hypercholesterolemia (HeFH)Homozygous Familial Hypercholesterolemia (HoFH)Familial Hypercholesterolemia
University of Wisconsin, Madison 70
Testing effectiveness (Phase 2)Study completedNCT05694260
What this trial is testing

A Clinical Study in Children With Heterozygous Familial Hypercholesterolemia (HeFH) Aged 6 to 17 Treated Once Daily With Bempedoic Acid Oral Dosing (CLEAR Path 1)

Who this might be right for
Hypercholesterolemia
Esperion Therapeutics, Inc. 31
Large-scale testing (Phase 3)Study completedNCT04652726
What this trial is testing

Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Heterozygous Familial Hypercholesterolemia

Who this might be right for
Familial Hypercholesterolemia - Heterozygous
Novartis Pharmaceuticals 141
Large-scale testing (Phase 3)Study completedNCT01824238
What this trial is testing

The Safety and Efficacy of Anacetrapib (MK-0859) When Added to Ongoing Statin Therapy in Japanese Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-050)

Who this might be right for
Heterozygous Familial Hypercholesterolemia (HeFH)
Merck Sharp & Dohme LLC 68
Large-scale testing (Phase 3)Study completedNCT03397121
What this trial is testing

Trial to Evaluate the Effect of Inclisiran Treatment on Low Density Lipoprotein Cholesterol (LDL-C) in Subjects With Heterozygous Familial Hypercholesterolemia (HeFH)

Who this might be right for
Heterozygous Familial HypercholesterolemiaElevated Cholesterol
The Medicines Company 482
Testing effectiveness (Phase 2)Study completedNCT04173793
What this trial is testing

PCSK9 Inhibitor AK102 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)

Who this might be right for
Heterozygous Familial Hypercholesterolemia
Akeso 109
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