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Results for “High LDL-c”

135 trials

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Showing 20 of 135 results

Early research (Phase 1)Study completedNCT02314442
What this trial is testing

An Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Who this might be right for
Hypercholesterolemia
Alnylam Pharmaceuticals 70
Early research (Phase 1)Study completedNCT00055042
What this trial is testing

Laser and Antioxidant Treatment of Diabetic Macular Edema

Who this might be right for
Macular EdemaDiabetes Mellitus
National Eye Institute (NEI) 40
Large-scale testing (Phase 3)Active Not RecruitingNCT05739383
What this trial is testing

Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Who this might be right for
Primary Prevention of Atherosclerotic Cardiovascular Disease
Novartis Pharmaceuticals 14,012
Testing effectiveness (Phase 2)Study completedNCT01652703
What this trial is testing

Evaluate Tolerability and Efficacy of Evolocumab (AMG 145) in Japanese Subjects

Who this might be right for
Hypercholesterolemia and High Risk for Cardiovascular Events
Amgen 310
Testing effectiveness (Phase 2)Study completedNCT04992065
What this trial is testing

A Research Study Looking at How NNC0385-0434 Tablets Work to Lower Blood Cholesterol in People With Heart Disease or a High Risk of Heart Disease

Who this might be right for
Atherosclerotic Cardiovascular Disease
Novo Nordisk A/S 267
Large-scale testing (Phase 3)Looking for participantsNCT06597006
What this trial is testing

Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia

Who this might be right for
Familial Hypercholesterolemia - Homozygous
Novartis Pharmaceuticals 9
Large-scale testing (Phase 3)Study completedNCT03814187
What this trial is testing

Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C

Who this might be right for
ASCVDElevated CholesterolHeterozygous Familial Hypercholesterolemia+1 more
Novartis Pharmaceuticals 3,275
Not applicableStudy completedNCT01690312
What this trial is testing

Clinical Study to Assess High-DHA Fish Oil on Biomarkers of Cardiovascular Disease Risk in Adults on Statin Therapy

Who this might be right for
Cardiovascular Disease
Nutrasource Pharmaceutical and Nutraceutical Services, Inc. 36
Large-scale testing (Phase 3)Study completedNCT02585778
What this trial is testing

Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin)

Who this might be right for
Hypercholesterolaemia
Sanofi 517
Testing effectiveness (Phase 2)Study completedNCT05421078
What this trial is testing

A Dose-Finding Study in Japanese Patients to Evaluate the Effect of Obicetrapib as an Adjunct to Stable Statin Therapy.

Who this might be right for
DyslipidemiaHypercholesterolemiaHigh Cholesterol
NewAmsterdam Pharma 102
Post-approval studies (Phase 4)Study completedNCT00644709
What this trial is testing

Atorvastatin For The Treatment Of High Cholesterol In Patients At High Risk Of Coronary Heart Disease (CHD)

Who this might be right for
Dyslipidemias
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 196
Early research (Phase 1)Study completedNCT06742853
What this trial is testing

Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.

Who this might be right for
Dyslipidemia
AstraZeneca 81
Not applicableNot Yet RecruitingNCT07615296
What this trial is testing

Target-Oriented Strategy of Ultra-Low LDL-C (<1.0 vs. 1.0-1.39 mmol/L) in Extreme-High-Risk ASCVD Patients: Clinical Benefit, Safety and Cost-Effectiveness Assessment

Who this might be right for
Atherosclerotic Cardiovascular Disease (ASCVD)
Beijing Anzhen Hospital 6,000
Large-scale testing (Phase 3)Study completedNCT01879319
What this trial is testing

Study to Assess in Home Use of Evolocumab (AMG 145) Administration Using Either an Automated Mini-doser or a Prefilled Autoinjector/Pen

Who this might be right for
Primary HypercholesterolemiaMixed Dyslipidemia
Amgen 164
Early research (Phase 1)Study completedNCT06573528
What this trial is testing

Study to Evaluate Safety, Tolerability and Pharmacokinetics of CS060380 in Healthy and Elevated LDL-C Subjects

Who this might be right for
MASH
Cascade Pharmaceuticals, Inc 104
Not applicableEnded earlyNCT01580319
What this trial is testing

Primary Prevention of Cardiovascular Diseases in Childhood and Adolescence: the Role of Physical Activity

Who this might be right for
ObesityHypercholesterolemiaHigh Blood Pressure+1 more
Instituto de Cardiologia do Rio Grande do Sul 27
Testing effectiveness (Phase 2)Looking for participantsNCT07477704
What this trial is testing

See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

Who this might be right for
Hypercholesterolemia
Regeneron Pharmaceuticals 420
Large-scale testing (Phase 3)Study completedNCT03001076
What this trial is testing

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)

Who this might be right for
HypercholesterolemiaAtherosclerosisStatin Adverse Reaction
Esperion Therapeutics, Inc. 269
Large-scale testing (Phase 3)Study completedNCT02624869
What this trial is testing

Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)

Who this might be right for
Familial Hypercholesterolemia
Amgen 163
Early research (Phase 1)Active Not RecruitingNCT06485245
What this trial is testing

Study to Evaluate Safety, Tolerability and Pharmacokinetics of CS060304 in Healthy and Elevated LDL-C Subjects

Who this might be right for
MASH
Cascade Pharmaceuticals, Inc 80
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