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Results for “Homozygous F508del Mutation”

47 trials

Showing 20 of 47 results

Large-scale testing (Phase 3)Ended earlyNCT03447262
What this trial is testing

A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 484
Large-scale testing (Phase 3)Study completedNCT01807923
What this trial is testing

Lumacaftor in Combination With Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Who Are Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis, Homozygous for the F508del CFTR Mutation
Vertex Pharmaceuticals Incorporated 559
Not applicableStudy completedNCT03894657
What this trial is testing

Validation of Respiratory Epithelial Functional Assessment to Predict Clinical Efficacy of Orkambi®.

Who this might be right for
Cystic FibrosisHomozygous F508del Mutation
Assistance Publique - Hôpitaux de Paris 91
Testing effectiveness (Phase 2)Ended earlyNCT00953706
What this trial is testing

Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 140
Testing effectiveness (Phase 2)Study completedNCT02508207
What this trial is testing

Evaluate Effects of VX-661/Ivacaftor on Lung and Extrapulmonary Systems in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 34
Large-scale testing (Phase 3)Study completedNCT03525574
What this trial is testing

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 507
Testing effectiveness (Phase 2)Study completedNCT02589236
What this trial is testing

Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Nivalis Therapeutics, Inc. 138
Testing effectiveness (Phase 2)Study completedNCT00742092
What this trial is testing

Miglustat in Cystic Fibrosis

Who this might be right for
Cystic Fibrosis
Actelion 11
Post-approval studies (Phase 4)Ended earlyNCT02823470
What this trial is testing

A Pilot Study to Evaluate the Use of Smart Adherence Technology to Measure Lumacaftor/Ivacaftor Adherence in CF Subjects Homozygous for the F508del CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 24
Large-scale testing (Phase 3)Study completedNCT03525548
What this trial is testing

VX-445 Combination Therapy in CF Subjects Homozygous for F508del (F/F)

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 113
Large-scale testing (Phase 3)Study completedNCT01931839
What this trial is testing

Rollover Study of Lumacaftor in Combination With Ivacaftor in Subjects 12 Years and Older With Cystic Fibrosis

Who this might be right for
Cystic Fibrosis, Homozygous or Heterozygous for the F508del-CFTR Mutation
Vertex Pharmaceuticals Incorporated 1,164
Large-scale testing (Phase 3)Study completedNCT03559062
What this trial is testing

Evaluate Efficacy and Safety of TEZ/IVA in Subjects Aged 6 Through 11 Years With Cystic Fibrosis

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 67
Large-scale testing (Phase 3)Study completedNCT02325362
What this trial is testing

Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the F508del Mutation

Who this might be right for
Cystic Fibrosis
Assistance Publique - Hôpitaux de Paris 16
Large-scale testing (Phase 3)Study completedNCT01897233
What this trial is testing

Study of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 62
Large-scale testing (Phase 3)Study completedNCT01807949
What this trial is testing

Lumacaftor in Combination With Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Who Are Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis, Homozygous for the F508del CFTR Mutation
Vertex Pharmaceuticals Incorporated 563
Large-scale testing (Phase 3)Study completedNCT02347657
What this trial is testing

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 510
Large-scale testing (Phase 3)Study completedNCT02797132
What this trial is testing

Safety and Pharmacokinetic Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Through 5 Years With Cystic Fibrosis, Homozygous for F508del

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 62
Testing effectiveness (Phase 2)Temporarily pausedNCT03756922
What this trial is testing

A DDI Study of FDL169 and FDL176 in Healthy Subjects

Who this might be right for
Cystic Fibrosis
Flatley Discovery Lab LLC 78
Large-scale testing (Phase 3)Study completedNCT02544451
What this trial is testing

Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With Lumacaftor in Combination With Ivacaftor

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 246
Testing effectiveness (Phase 2)Study completedNCT01225211
What this trial is testing

Study of VX-809 Alone and in Combination With VX-770 in Cystic Fibrosis (CF) Patients Homozygous or Heterozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 312
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