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Results for “Homozygous F508del Mutation”

Showing 20 of 0 results

Testing effectiveness (Phase 2)Study completedNCT01531673
What this trial is testing

Study of VX-661 Alone and in Combination With Ivacaftor in Subjects Homozygous or Heterozygous to the F508del-Cystic Fibrosis Transmembrane Conductance Regulator(CFTR) Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 194
Testing effectiveness (Phase 2)Study completedNCT03119649
What this trial is testing

Evaluate Multiple Doses of GLPG2222 in Adult Subjects With Cystic Fibrosis

Who this might be right for
Cystic Fibrosis
Lakefront Biotherapeutics NV 59
Testing effectiveness (Phase 2)Study completedNCT00945347
What this trial is testing

Does a Nasal Instillation of Miglustat Normalize the Nasal Potential Difference in Cystic Fibrosis Patients ?

Who this might be right for
Cystic Fibrosis
Cliniques universitaires Saint-Luc- Université Catholique de Louvain 10
Large-scale testing (Phase 3)Study completedNCT03460990
What this trial is testing

VX-659 Combination Therapy in CF Subjects Homozygous for F508del (F/F)

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 116
Testing effectiveness (Phase 2)Study completedNCT00865904
What this trial is testing

Study of VX-809 in Cystic Fibrosis Subjects With the ∆F508-CFTR Gene Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 93
Early research (Phase 1)Study completedNCT02275936
What this trial is testing

Study of N91115 in Patients With Cystic Fibrosis Homozygous F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Nivalis Therapeutics, Inc. 51
Large-scale testing (Phase 3)Study completedNCT02565914
What this trial is testing

Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 1,131
Testing effectiveness (Phase 2)Study completedNCT02709109
What this trial is testing

Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Parion Sciences 147
Testing effectiveness (Phase 2)Ended earlyNCT04853368
What this trial is testing

Study to Evaluate Adverse Events and Change in Disease Activity With Oral Capsules of Galicaftor/Navocaftor/ABBV-119 or Galicaftor/Navocaftor/ABBV-576 Combination Therapies in Adult Participants With Cystic Fibrosis

Who this might be right for
Cystic Fibrosis (CF)
AbbVie 48
Testing effectiveness (Phase 2)Ended earlyNCT01002534
What this trial is testing

Does a Nasal Instillation of Vardenafil Normalize the Nasal Potential Difference in Cystic Fibrosis Patients?

Who this might be right for
Cystic Fibrosis
Cliniques universitaires Saint-Luc- Université Catholique de Louvain 5
Not applicableStudy completedNCT03795363
What this trial is testing

Orkambi Treatment in 2 to 5 Year Old Children With CF

Who this might be right for
Cystic Fibrosis
Children's Hospital of Philadelphia 28
Early research (Phase 1)Study completedNCT03093714
What this trial is testing

Evaluate Safety, PK and PD of FDL169 in Cystic Fibrosis Subjects

Who this might be right for
Cystic Fibrosis
Flatley Discovery Lab LLC 27
Testing effectiveness (Phase 2)Ended earlyNCT02649751
What this trial is testing

Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
University Hospital, Brest 49
Large-scale testing (Phase 3)Study completedNCT02514473
What this trial is testing

Evaluate the Efficacy and Safety of Lumacaftor in Combination With Ivacaftor in Subjects With CF, Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 206
Large-scale testing (Phase 3)Study completedNCT03125395
What this trial is testing

A Rollover Safety Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Years and Older With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 57
Large-scale testing (Phase 3)Study completedNCT03537651
What this trial is testing

Evaluate the Safety and Efficacy of Long-term Treatment With TEZ/IVA in CF Participants With an F508del CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 130
Large-scale testing (Phase 3)Study completedNCT03150719
What this trial is testing

Evaluate Safety, Efficacy, and Tolerability of TEZ/IVA in Orkambi® (Lumacaftor/Ivacaftor) -Experienced Subjects With Cystic Fibrosis (CF)

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 98
Early research (Phase 1)Study completedNCT01746784
What this trial is testing

Safety and Pharmacokinetic Study of N6022 in Subjects With Cystic Fibrosis Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Nivalis Therapeutics, Inc. 66
Testing effectiveness (Phase 2)Study completedNCT03474042
What this trial is testing

GLPG2737 on Top of Orkambi in Subjects With Cystic Fibrosis

Who this might be right for
Cystic Fibrosis
Lakefront Biotherapeutics NV 22
Large-scale testing (Phase 3)Study completedNCT05076149
What this trial is testing

VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 597
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