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Results for “Hypercholesterolemia, Autosomal Dominant, 3”

40 trials

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Showing 20 of 40 results

Large-scale testing (Phase 3)Not Yet RecruitingNCT07473843
What this trial is testing

Study of Zodasiran in Adolescent Participants With Homozygous Familial Hypercholesterolemia

Who this might be right for
Homozygous Familial Hypercholesterolemia
Arrowhead Pharmaceuticals 12
Large-scale testing (Phase 3)Study completedNCT00867165
What this trial is testing

Pediatric Study to Evaluate the Efficacy and Safety of Ezetimibe Monotherapy in Children With Primary Hypercholesterolemia (P05522)

Who this might be right for
Primary Hypercholesterolemia
Organon and Co 138
Testing effectiveness (Phase 2)Study completedNCT01604824
What this trial is testing

Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene

Who this might be right for
Hypercholesterolemia
Regeneron Pharmaceuticals 23
Large-scale testing (Phase 3)WithdrawnNCT02765841
What this trial is testing

Evaluate the Efficacy and Safety of Lomitapide in Pediatric Patients With Homozygous Familial Hypercholesterolemia on Stable Lipid-lowering Therapy

Who this might be right for
Homozygous Familial Hypercholesterolemia
Aegerion Pharmaceuticals, Inc.
Large-scale testing (Phase 3)Study completedNCT05952856
What this trial is testing

Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids

Who this might be right for
HypercholesterolemiaFamilial Hypercholesterolemia
Merck Sharp & Dohme LLC 2,912
Testing effectiveness (Phase 2)Study completedNCT01375777
What this trial is testing

Monoclonal Antibody Against PCSK9 to Reduce Elevated Low-density Lipoprotein Cholesterol (LDL-C) in Adults Currently Not Receiving Drug Therapy for Easing Lipid Levels

Who this might be right for
Hyperlipidemia
Amgen 411
Early research (Phase 1)Study completedNCT07216131
What this trial is testing

Investigate the Effect of AZD0780 on Metformin Pharmacokinetics in Healthy Adult Volunteers Aged 18 to 55 Years

Who this might be right for
Healthy Participants
AstraZeneca 14
Large-scale testing (Phase 3)Study completedNCT05425745
What this trial is testing

Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.

Who this might be right for
DyslipidemiasHigh CholesterolHypercholesterolemia+6 more
NewAmsterdam Pharma 354
Large-scale testing (Phase 3)Study completedNCT01588496
What this trial is testing

Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities

Who this might be right for
Homozygous Familial Hypercholesterolemia
Amgen 58
Large-scale testing (Phase 3)Study completedNCT04031742
What this trial is testing

Evaluate Safety and Efficacy of IBI306, a PCSK9 Monoclonal Antibody in Chinese Subjects With Homozygous Familial Hypercholesterolemia

Who this might be right for
Homozygous Familial Hypercholesterolemia
Innovent Biologics (Suzhou) Co. Ltd. 18
Testing effectiveness (Phase 2)Study completedNCT03944577
What this trial is testing

Impact of Evolocumab in Cardiac Transplant Patients With CAV

Who this might be right for
Heart Transplant
University of Nebraska 26
Large-scale testing (Phase 3)Active Not RecruitingNCT06712771
What this trial is testing

Clinical Trial to Evaluate the Efficacy and Safety of VSA003 in Chinese HoFH Patients

Who this might be right for
Homozygous Familial Hypercholesterolemia (HoFH)
Visirna Therapeutics HK Limited 46
Large-scale testing (Phase 3)Study completedNCT02729025
What this trial is testing

Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition on Arterial Wall Inflammation in Patients With Elevated Lipoprotein(a) (Lp(a))

Who this might be right for
Subjects With Hyperlipidemia, Dyslipidemia
Amgen 129
Large-scale testing (Phase 3)Looking for participantsNCT07614958
What this trial is testing

Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days

Who this might be right for
Mixed DyslipidemiaHypercholesterolaemia
A. Menarini International Licensing S.A. 426
Large-scale testing (Phase 3)Study completedNCT02833844
What this trial is testing

Safety, Tolerability and Efficacy on Low Density Lipoprotein Cholesterol (LDL-C) of Evolocumab in Participants With Human Immunodeficiency Virus (HIV) and Hyperlipidemia/Mixed Dyslipidemia

Who this might be right for
Subjects With Hyperlipidemia, Dyslipidemia and HIV Infection
Amgen 467
Large-scale testing (Phase 3)Study completedNCT01475825
What this trial is testing

The Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol

Who this might be right for
HypercholesterolemiaHeterozygous Familial
Kastle Therapeutics, LLC 309
Large-scale testing (Phase 3)Study completedNCT01968980
What this trial is testing

A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia

Who this might be right for
Heterozygous Familial Hypercholesterolemia
Pfizer 370
Not applicableLooking for participantsNCT04485871
What this trial is testing

Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids

Who this might be right for
Type 2 DiabetesInflammationInsulin Sensitivity/Resistance+1 more
Institut de Recherches Cliniques de Montreal 48
Large-scale testing (Phase 3)Study completedNCT00136981
What this trial is testing

Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.

Who this might be right for
Hypercholesterolemia, FamilialHyperlipidemia
Pfizer 800
Large-scale testing (Phase 3)Study completedNCT02173158
What this trial is testing

Efficacy and Safety of Lomitapide in Japanese Patients With HoFH on Concurrent Lipid-Lowering Therapy

Who this might be right for
Familial Hypercholesterolemia - Homozygous
Aegerion Pharmaceuticals, Inc. 9
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