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Results for “KIT Gene Mutation”

52 trials

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Showing 20 of 52 results

Testing effectiveness (Phase 2)Looking for participantsNCT06316960
What this trial is testing

Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation

Who this might be right for
AML, ChildhoodRelapse/RecurrenceRefractory AML+2 more
Children's Hospital of Soochow University 50
Testing effectiveness (Phase 2)Study completedNCT00782067
What this trial is testing

Efficacy and Safety of Midostaurin in Patients With Aggressive Systemic Mastocytosis or Mast Cell Leukemia

Who this might be right for
Leukemia
Novartis Pharmaceuticals 116
Testing effectiveness (Phase 2)Study completedNCT00831974
What this trial is testing

Efficacy of AB1010 in Patients With Systemic Indolent Mastocytosis

Who this might be right for
Mastocytosis
AB Science 23
Testing effectiveness (Phase 2)UnknownNCT02501551
What this trial is testing

Regorafenib, C-kit Mutated Malignant Melanoma, 2nd Line Therapy

Who this might be right for
Melanoma
Yonsei University 36
Testing effectiveness (Phase 2)Study completedNCT01395121
What this trial is testing

A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread

Who this might be right for
Mucosal Lentiginous MelanomaAcral Lentiginous Malignant Melanoma
Institute of Cancer Research, United Kingdom 29
Testing effectiveness (Phase 2)Active Not RecruitingNCT06208748
What this trial is testing

SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST

Who this might be right for
Gastrointestinal Stromal TumorsGIST
Sarcoma Alliance for Research through Collaboration 40
Testing effectiveness (Phase 2)Looking for participantsNCT07028073
What this trial is testing

A New Treatment of Newly Diagnosed KIT Mutation CBF-Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia With T(8;21)(Q22;Q22)Acute Myeloid Leukemia With T(16;16)(P13;Q22)KIT Gene Mutation+1 more
The First Affiliated Hospital of Soochow University 78
Testing effectiveness (Phase 2)Looking for participantsNCT05009927
What this trial is testing

Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)

Who this might be right for
Metastatic Gastrointestinal Stromal Tumor (GIST)C-KIT MutationAdvanced Gastrointestinal Stromal Tumor (GIST)
Centre Leon Berard 50
Not applicableLooking for participantsNCT06645236
What this trial is testing

DHF-20-1839-2: Clinical Performance Study Protocol for Therascreen® KRAS RGQ PCR Kit

Who this might be right for
Metastatic Colorectal Cancer (mCRC)
QIAGEN Gaithersburg, Inc 600
Early research (Phase 1)Study completedNCT01531361
What this trial is testing

Vemurafenib With Sorafenib Tosylate or Crizotinib in Treating Patients With Advanced Malignancies With BRAF Mutations

Who this might be right for
Advanced Malignant NeoplasmBRAF Gene MutationMetastatic Malignant Neoplasm+2 more
M.D. Anderson Cancer Center 46
Not applicableUnknownNCT01066286
What this trial is testing

Genome Wide SNP Array-based Approach to Detect Micro-cytogenetic Lesions and KIT Mutation to Improve Treatment Outcomes in Patients With Core-binding Factor Positive Acute Myeloid Leukemia

Who this might be right for
Myeloid Leukemia
Samsung Medical Center 100
Testing effectiveness (Phase 2)Study completedNCT01266369
What this trial is testing

Masitinib in Patients With Mastocytosis With Handicap and Bearing the D816V Mutation

Who this might be right for
Mastocytosis
AB Science 21
Not applicableLooking for participantsNCT07143669
What this trial is testing

Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations

Who this might be right for
Clonal Mast Cell DiseaseKIT D816V MutationSuspected KITD816V Mutated Clonal Mast Cell Disease
Blueprint Medicines Corporation 450
Large-scale testing (Phase 3)Not Yet RecruitingNCT05970900
What this trial is testing

Preoperative Imatinib Mesylate Combined With Rectal-sparing Surgery in Patients With c-KIT Gene-mutant Rectal GIST

Who this might be right for
Gastrointestinal Stromal Tumor of Rectum
Fujian Medical University Union Hospital 23
Testing effectiveness (Phase 2)WithdrawnNCT02812693
What this trial is testing

Pembrolizumab and Imatinib in Patients With Locally Advanced/Metastatic Melanoma With c-KIT Mutation/Amplification

Who this might be right for
Stage IIIA Skin MelanomaStage IIIB Skin MelanomaStage IIIC Skin Melanoma+1 more
Joanne Jeter
Testing effectiveness (Phase 2)Active Not RecruitingNCT03731260
What this trial is testing

(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis

Who this might be right for
Indolent Systemic Mastocytosis
Blueprint Medicines Corporation 251
Testing effectiveness (Phase 2)Study completedNCT01396148
What this trial is testing

Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor

Who this might be right for
Gastrointestinal Stromal Tumors
Pfizer 6
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06772233
What this trial is testing

Regorafenib Combined With Envafolimab for Metastatic Gastrointestinal Stromal Tumors With Kit Gene Exon 17 Mutation That Failed Standard Treatment

Who this might be right for
Metastatic Gastrointestinal Stromal Tumors (GIST)
Peking University 100
Testing effectiveness (Phase 2)Study completedNCT00171912
What this trial is testing

Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes

Who this might be right for
Hypereosinophilic SyndromeSystemic MastocytosisChronic Myelomonocytic Leukemia+1 more
Novartis Pharmaceuticals 38
Not applicableNot Yet RecruitingNCT07264959
What this trial is testing

An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)

Who this might be right for
Indolent Systemic Mastocytosis
Blueprint Medicines Corporation 150
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