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Results for “KIT Gene Mutation”

54 trials

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Showing 20 of 54 results

Testing effectiveness (Phase 2)WithdrawnNCT02812693
What this trial is testing

Pembrolizumab and Imatinib in Patients With Locally Advanced/Metastatic Melanoma With c-KIT Mutation/Amplification

Who this might be right for
Stage IIIA Skin MelanomaStage IIIB Skin MelanomaStage IIIC Skin Melanoma+1 more
Joanne Jeter
Testing effectiveness (Phase 2)Study completedNCT01396148
What this trial is testing

Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor

Who this might be right for
Gastrointestinal Stromal Tumors
Pfizer 6
Large-scale testing (Phase 3)UnknownNCT04333108
What this trial is testing

Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment

Who this might be right for
Indolent Systemic Mastocytosis
AB Science 140
Testing effectiveness (Phase 2)UnknownNCT05821738
What this trial is testing

Avapritinib in CBF-AML With KIT Mutations

Who this might be right for
Core Binding Factor Acute Myeloid LeukemiaKIT Mutation-Related Tumors
The First Affiliated Hospital of Soochow University 50
Testing effectiveness (Phase 2)Study completedNCT01395121
What this trial is testing

A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread

Who this might be right for
Mucosal Lentiginous MelanomaAcral Lentiginous Malignant Melanoma
Institute of Cancer Research, United Kingdom 29
Testing effectiveness (Phase 2)Study completedNCT02272998
What this trial is testing

Ponatinib for Patients Whose Advanced Solid Tumor Cancer Has Activating Mutations Involving the Following Genes: FGFR1, FGFR2, FGFR3, FGFR4, RET, KIT.

Who this might be right for
Malignant Neoplasm
Sameek Roychowdhury 22
Not applicableLooking for participantsNCT07255638
What this trial is testing

A Non-Interventional Study in Participants With Indolent Systemic Mastocytosis (ISM) in Germany

Who this might be right for
Indolent Systemic Mastocytosis
Blueprint Medicines Corporation 80
Not applicableStudy completedNCT05347745
What this trial is testing

Therascreen® KRAS RGQ PCR Kit

Who this might be right for
Colo-rectal Cancer
QIAGEN Gaithersburg, Inc 219
Not applicableUnknownNCT01227746
What this trial is testing

A Retrospective Study of C-kit Mutation Status in Asian Patients With Advanced Gastro-intestinal Stromal Tumors (GIST) Treated With Imatinib.

Who this might be right for
Asian Patients With Advanced Gastro-intestinal Stromal Tumors (GIST) Treated With Imatinib
National University Hospital, Singapore
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06765915
What this trial is testing

Avapritinib Maintenance for AML With KIT Mutations

Who this might be right for
AML, Adult
Ruijin Hospital 47
Testing effectiveness (Phase 2)UnknownNCT01168050
What this trial is testing

Efficacy of Nilotinib in First or Second Line Treatment of Primary Melanomas Stage III Unresectable Melanomas.

Who this might be right for
Malignant Skin Melanoma T0Stage III MelanomaStage IV Melanoma+1 more
Assistance Publique - Hôpitaux de Paris 25
Early research (Phase 1)Study completedNCT01531361
What this trial is testing

Vemurafenib With Sorafenib Tosylate or Crizotinib in Treating Patients With Advanced Malignancies With BRAF Mutations

Who this might be right for
Advanced Malignant NeoplasmBRAF Gene MutationMetastatic Malignant Neoplasm+2 more
M.D. Anderson Cancer Center 46
Not applicableStudy completedNCT04811365
What this trial is testing

(PROSPECTOR) Screening Study Evaluating the Prevalence of the KIT D816V Mutation in Patients With Systemic Mast Cell Activation

Who this might be right for
Systemic Mast Cell ActivationKIT D816V Mutation
Blueprint Medicines Corporation 379
Testing effectiveness (Phase 2)UnknownNCT02461849
What this trial is testing

Patients With Refractory, Metastatic Cancer Harboring KIT Mutation or Amplification to Investigate the Clinical Efficacy and Safety of Imatinib Therapy

Who this might be right for
Advanced, Refractory Cancer
Samsung Medical Center 14
Not applicableUnknownNCT02661009
What this trial is testing

Human EGFR Mutations Quantitative Detection Kit (Real-time Fluorescent PCR Method)

Who this might be right for
Non Small Cell Lung CancerEGFR-TKI Resistant MutationEGFR-TKI Sensitizing Mutation
GenoSaber 1,000
Testing effectiveness (Phase 2)Active Not RecruitingNCT06208748
What this trial is testing

SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST

Who this might be right for
Gastrointestinal Stromal TumorsGIST
Sarcoma Alliance for Research through Collaboration 40
Not applicableLooking for participantsNCT07562542
What this trial is testing

Peripheral Blood KIT-D816V Mutation in Adult Systemic Mastocytosis

Who this might be right for
Systemic MastocytosisKIT-D816V Mutation
The First Affiliated Hospital of Soochow University 50
Large-scale testing (Phase 3)Study completedNCT02260505
What this trial is testing

Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)

Who this might be right for
Gastrointestinal Stromal TumorsResected Gastrointestinal Stromal TumorsNon-metastatic+2 more
Centre Leon Berard 136
Testing effectiveness (Phase 2)Study completedNCT02606097
What this trial is testing

Regorafenib in GIST With Secondary C-KIT Exon 17 Mutation

Who this might be right for
Gastrointestinal Stromal Tumour (GIST)
Chang Gung Memorial Hospital 19
Testing effectiveness (Phase 2)Study completedNCT03580655
What this trial is testing

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

Who this might be right for
Advanced Systemic MastocytosisAggressive Systemic MastocytosisSystemic Mastocytosis With an Associated Hematologic Neoplasm+1 more
Blueprint Medicines Corporation 107
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