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Results for “KIT Gene Mutation”

52 trials

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Showing 20 of 52 results

Not applicableLooking for participantsNCT06573073
What this trial is testing

Evaluation of Clinical Performance and IVD Test of LifeOS Digital PCR Liquid Biopsy Kits for EGFR T790M Mutation

Who this might be right for
Non Small Cell Lung CancerEGFR T790M
LifeOS Genomics Corporation 300
Large-scale testing (Phase 3)Not Yet RecruitingNCT05970900
What this trial is testing

Preoperative Imatinib Mesylate Combined With Rectal-sparing Surgery in Patients With c-KIT Gene-mutant Rectal GIST

Who this might be right for
Gastrointestinal Stromal Tumor of Rectum
Fujian Medical University Union Hospital 23
Not applicableLooking for participantsNCT06116318
What this trial is testing

C-Kit Mutation as MRD in Acute Myeloid Leukemia

Who this might be right for
C-KIT Mutation
Institute of Hematology & Blood Diseases Hospital, China 50
Testing effectiveness (Phase 2)Study completedNCT01028222
What this trial is testing

AMNN107 in the Treatment of Metastatic and/or Inoperable Melanoma Harboring a c-Kit Mutation

Who this might be right for
Melanoma
Novartis Pharmaceuticals 55
Not applicableUnknownNCT05895942
What this trial is testing

Exploring the Molecular Mechanism Based on KIT Mutation

Who this might be right for
GIST
Xijing Hospital 190
Not applicableLooking for participantsNCT07255638
What this trial is testing

A Non-Interventional Study in Participants With Indolent Systemic Mastocytosis (ISM) in Germany

Who this might be right for
Indolent Systemic Mastocytosis
Blueprint Medicines Corporation 80
Testing effectiveness (Phase 2)Study completedNCT00171912
What this trial is testing

Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes

Who this might be right for
Hypereosinophilic SyndromeSystemic MastocytosisChronic Myelomonocytic Leukemia+1 more
Novartis Pharmaceuticals 38
Testing effectiveness (Phase 2)Active Not RecruitingNCT03731260
What this trial is testing

(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis

Who this might be right for
Indolent Systemic Mastocytosis
Blueprint Medicines Corporation 251
Not applicableLooking for participantsNCT07143669
What this trial is testing

Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations

Who this might be right for
Clonal Mast Cell DiseaseKIT D816V MutationSuspected KITD816V Mutated Clonal Mast Cell Disease
Blueprint Medicines Corporation 450
Large-scale testing (Phase 3)UnknownNCT04333108
What this trial is testing

Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment

Who this might be right for
Indolent Systemic Mastocytosis
AB Science 140
Not applicableUnknownNCT01066286
What this trial is testing

Genome Wide SNP Array-based Approach to Detect Micro-cytogenetic Lesions and KIT Mutation to Improve Treatment Outcomes in Patients With Core-binding Factor Positive Acute Myeloid Leukemia

Who this might be right for
Myeloid Leukemia
Samsung Medical Center 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT06087263
What this trial is testing

Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.

Who this might be right for
Gastrointestinal Stromal Tumors
M.D. Anderson Cancer Center 3
Testing effectiveness (Phase 2)Study completedNCT01396148
What this trial is testing

Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor

Who this might be right for
Gastrointestinal Stromal Tumors
Pfizer 6
Not applicableNot Yet RecruitingNCT07264959
What this trial is testing

An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)

Who this might be right for
Indolent Systemic Mastocytosis
Blueprint Medicines Corporation 150
Testing effectiveness (Phase 2)Study completedNCT03580655
What this trial is testing

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

Who this might be right for
Advanced Systemic MastocytosisAggressive Systemic MastocytosisSystemic Mastocytosis With an Associated Hematologic Neoplasm+1 more
Blueprint Medicines Corporation 107
Testing effectiveness (Phase 2)Study completedNCT00278876
What this trial is testing

Adjuvant Imatinib in High-risk Gastrointestinal Stromal Tumor (GIST) With C-kit Mutation

Who this might be right for
SarcomaGastrointestinal Stromal Tumors
Asan Medical Center 47
Testing effectiveness (Phase 2)UnknownNCT01541709
What this trial is testing

Imatinib Dose Escalation to 800 mg/Day in Korean Patients With Metastatic or Unresectable GIST Harboring KIT Exon 9 Mutation: KENEDI

Who this might be right for
Gastrointestinal Stromal Tumors
Asan Medical Center 23
Not applicableStudy completedNCT04811365
What this trial is testing

(PROSPECTOR) Screening Study Evaluating the Prevalence of the KIT D816V Mutation in Patients With Systemic Mast Cell Activation

Who this might be right for
Systemic Mast Cell ActivationKIT D816V Mutation
Blueprint Medicines Corporation 379
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06765915
What this trial is testing

Avapritinib Maintenance for AML With KIT Mutations

Who this might be right for
AML, Adult
Ruijin Hospital 47
Testing effectiveness (Phase 2)Study completedNCT02606097
What this trial is testing

Regorafenib in GIST With Secondary C-KIT Exon 17 Mutation

Who this might be right for
Gastrointestinal Stromal Tumour (GIST)
Chang Gung Memorial Hospital 19
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