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Results for “KMT2A”

51 trials

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Showing 20 of 51 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT05761171
What this trial is testing

Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Who this might be right for
Recurrent Acute Leukemia of Ambiguous LineageRecurrent Acute Lymphoblastic LeukemiaRecurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage+9 more
Children's Oncology Group 78
Testing effectiveness (Phase 2)Study completedNCT00416598
What this trial is testing

Decitabine as Maintenance Therapy After Standard Therapy in Treating Patients With Previously Untreated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia With Myelodysplasia-Related ChangesAdult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11+4 more
National Cancer Institute (NCI) 546
Testing effectiveness (Phase 2)Ended earlyNCT00866281
What this trial is testing

The Safety and Preliminary Efficacy of Oral Midostaurin (PKC412) in Relapsed or Refractory Pediatric Leukemia

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic Leukemia
Novartis Pharmaceuticals 22
Large-scale testing (Phase 3)Looking for participantsNCT07007312
What this trial is testing

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Who this might be right for
Acute Myeloid Leukemia (AML)
Kura Oncology, Inc. 1,300
Early research (Phase 1)Looking for participantsNCT06575296
What this trial is testing

Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

Who this might be right for
Acute LeukemiaAcute Leukemia of Ambiguous LineageAcute Lymphoblastic Leukemia+5 more
City of Hope Medical Center 27
Early research (Phase 1)Looking for participantsNCT06001788
What this trial is testing

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Who this might be right for
AMLAML With Mutated NPM1Hematologic Malignancy+9 more
Kura Oncology, Inc. 171
Large-scale testing (Phase 3)Study completedNCT01307579
What this trial is testing

Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaAdult Acute Monoblastic LeukemiaAdult Acute Monocytic Leukemia+25 more
Children's Oncology Group 517
Early research (Phase 1)Not Yet RecruitingNCT07283640
What this trial is testing

A Phase IB Trial of Subcutaneous Blinatumomab in Combination With Revumenib for Patients With KMT2A-rearranged Acute Lymphoblastic Leukemia

Who this might be right for
BlinatumomabRevumenibLymphoblastic Leukemia+1 more
M.D. Anderson Cancer Center 20
Early research (Phase 1)Looking for participantsNCT06376162
What this trial is testing

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

Who this might be right for
Relapsed/Refractory KMT2A-r Acute LeukemiaRelapsed/Refractory NUP98-r Acute LeukemiaRelapsed/Refractory NPM1-m Acute Leukemia
PedAL BCU, LLC 20
Early research (Phase 1)Active Not RecruitingNCT03513484
What this trial is testing

Nintedanib and Azacitidine in Treating Participants With HOX Gene Overexpression Relapsed or Refractory Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2AFibroblast Growth Factor Basic Form MeasurementFLT3 Internal Tandem Duplication+2 more
Northwestern University 44
Early research (Phase 1)Active Not RecruitingNCT05453903
What this trial is testing

Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies

Who this might be right for
Leukemia, Myeloid, Acute
Janssen Research & Development, LLC 196
Large-scale testing (Phase 3)Looking for participantsNCT05327894
What this trial is testing

Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia

Who this might be right for
Acute Lymphoblastic LeukemiaMixed Phenotype Acute Leukemia
Princess Maxima Center for Pediatric Oncology 160
Early research (Phase 1)Looking for participantsNCT03826992
What this trial is testing

Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia

Who this might be right for
Leukemia
Children's Hospital Medical Center, Cincinnati 21
Large-scale testing (Phase 3)Study completedNCT00093470
What this trial is testing

Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission

Who this might be right for
Acute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAdult Acute Megakaryoblastic LeukemiaAdult Acute Monocytic Leukemia+14 more
National Cancer Institute (NCI) 144
Testing effectiveness (Phase 2)Looking for participantsNCT04065399
What this trial is testing

Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMixed Lineage Acute Leukemia+2 more
Syndax Pharmaceuticals 447
Testing effectiveness (Phase 2)Active Not RecruitingNCT00658814
What this trial is testing

Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaAdult Acute Megakaryoblastic LeukemiaAdult Acute Monoblastic Leukemia+11 more
National Cancer Institute (NCI) 133
Early research (Phase 1)Study completedNCT02141828
What this trial is testing

Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patients With Relapsed/Refractory Leukemias Bearing a Rearrangement of the MLL Gene

Who this might be right for
LeukemiaAcute Myeloid LeukemiaAcute Lymphocytic Leukemia+1 more
Epizyme, Inc. 18
Early research (Phase 1)WithdrawnNCT05521087
What this trial is testing

JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias

Who this might be right for
Acute LeukemiasAcute Myeloid LeukemiaAcute Lymphoblastic Leukemia+1 more
Janssen Research & Development, LLC
Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
Large-scale testing (Phase 3)Looking for participantsNCT07223814
What this trial is testing

Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)

Who this might be right for
Acute Myeloid Leukemia
Stichting Hemato-Oncologie voor Volwassenen Nederland 875
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