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Results for “KMT2A”

54 trials

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Showing 20 of 54 results

Large-scale testing (Phase 3)Looking for participantsNCT06852222
What this trial is testing

Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

Who this might be right for
Leukemia, Myeloid, Acute
Janssen Research & Development, LLC 600
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07636564
What this trial is testing

Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment

Who this might be right for
Acute Leukemia of Ambiguous LineageB Acute Lymphoblastic LeukemiaB Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative+1 more
SWOG Cancer Research Network 90
Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
Testing effectiveness (Phase 2)Active Not RecruitingNCT01627041
What this trial is testing

Decitabine, Cytarabine, and Daunorubicin Hydrochloride in Treating Patients With Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaAdult Acute Basophilic LeukemiaAdult Acute Monoblastic Leukemia+7 more
National Cancer Institute (NCI) 178
Large-scale testing (Phase 3)Study completedNCT00093470
What this trial is testing

Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission

Who this might be right for
Acute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAdult Acute Megakaryoblastic LeukemiaAdult Acute Monocytic Leukemia+14 more
National Cancer Institute (NCI) 144
Early research (Phase 1)Study completedNCT00588991
What this trial is testing

Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders

Who this might be right for
Adult Acute Megakaryoblastic LeukemiaAdult Acute Monoblastic LeukemiaAdult Acute Monocytic Leukemia+20 more
National Cancer Institute (NCI) 12
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple Myeloma+1 more
Sumitomo Pharma America, Inc. 606
Not applicableLooking for participantsNCT06328179
What this trial is testing

Clinical Study Protocol for the Treatment of ND-AML and RR-AML With KMT2A Gene Abnormalities Using VHEA.

Who this might be right for
Acute Myeloid Leukemia
Huai'an First People's Hospital 34
Early research (Phase 1)Study completedNCT05326516
What this trial is testing

Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia

Who this might be right for
Relapsed/Refractory LeukemiasAcute Lymphoblastic LeukemiaAcute Lymphocytic Leukemia+3 more
Syndax Pharmaceuticals 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT05761171
What this trial is testing

Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Who this might be right for
Recurrent Acute Leukemia of Ambiguous LineageRecurrent Acute Lymphoblastic LeukemiaRecurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage+9 more
Children's Oncology Group 78
Not applicableLooking for participantsNCT07559695
What this trial is testing

A Real-world Study on the Efficacy and Safety of Menin Inhibitors as Maintenance After Allo-HSCT

Who this might be right for
Menin InhibitorsAcute LeukemiaPost Hematopoietic Stem Cell Transplantation+4 more
The First Affiliated Hospital of Soochow University 20
Early research (Phase 1)Looking for participantsNCT07270770
What this trial is testing

BY002 IIT Study in R/R Acute Leukemia

Who this might be right for
Acute LeukemiaKMT2A Rearrangements or NPM1 Mutations Acute Leukemia
The First Affiliated Hospital of Soochow University 18
Testing effectiveness (Phase 2)Study completedNCT02828358
What this trial is testing

Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

Who this might be right for
Acute Leukemia of Ambiguous LineageB Acute Lymphoblastic LeukemiaMixed Phenotype Acute Leukemia
National Cancer Institute (NCI) 78
Not applicableNo Longer AvailableNCT05918913
What this trial is testing

Expanded Access Program for Revumenib

Who this might be right for
Relapsed/Refractory Acute Leukemia
Syndax Pharmaceuticals
Testing effectiveness (Phase 2)Active Not RecruitingNCT00658814
What this trial is testing

Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaAdult Acute Megakaryoblastic LeukemiaAdult Acute Monoblastic Leukemia+11 more
National Cancer Institute (NCI) 133
Early research (Phase 1)Looking for participantsNCT06440135
What this trial is testing

Ziftomenib Maintenance Post Allo-HCT

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia in RemissionNPM1 Mutation+1 more
Massachusetts General Hospital 22
Early research (Phase 1)Active Not RecruitingNCT05453903
What this trial is testing

Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies

Who this might be right for
Leukemia, Myeloid, Acute
Janssen Research & Development, LLC 196
Testing effectiveness (Phase 2)Ended earlyNCT00866281
What this trial is testing

The Safety and Preliminary Efficacy of Oral Midostaurin (PKC412) in Relapsed or Refractory Pediatric Leukemia

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic Leukemia
Novartis Pharmaceuticals 22
Testing effectiveness (Phase 2)Active Not RecruitingNCT06052813
What this trial is testing

BN104 in the Treatment of Acute Leukemia

Who this might be right for
ALL, AdultAML, AdultAcute Leukaemia+4 more
Institut de Recherches Internationales Servier (I.R.I.S.) 66
Large-scale testing (Phase 3)Looking for participantsNCT07223814
What this trial is testing

Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)

Who this might be right for
Acute Myeloid Leukemia
Stichting Hemato-Oncologie voor Volwassenen Nederland 875
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