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Results for “KRAS P.G12C”

152 trials

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Showing 20 of 152 results

Early research (Phase 1)Study completedNCT04330664
What this trial is testing

Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)

Who this might be right for
Advanced CancerMetastatic CancerMalignant Neoplastic Disease
Mirati Therapeutics Inc. 86
Early research (Phase 1)Looking for participantsNCT06804824
What this trial is testing

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Vividion Therapeutics, Inc. 220
Testing effectiveness (Phase 2)Active Not RecruitingNCT04625647
What this trial is testing

Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Who this might be right for
Lung AdenocarcinomaLung Non-Small Cell CarcinomaRecurrent Lung Non-Squamous Non-Small Cell Carcinoma+3 more
SWOG Cancer Research Network 116
Testing effectiveness (Phase 2)UnknownNCT05993455
What this trial is testing

Basket Trial in Which Patients With Advanced Solid Tumors Carrying the KRAS G12C mUtation Receive Treatment With a Combination of Sotorasib and Panitumumab

Who this might be right for
Efficacy
Korea University Anam Hospital 24
Early research (Phase 1)Looking for participantsNCT06403436
What this trial is testing

A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorAdult Solid TumorAdult Disease+5 more
TOLREMO therapeutics AG 50
Testing effectiveness (Phase 2)Looking for participantsNCT05398094
What this trial is testing

Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy

Who this might be right for
Non-small Cell Lung Cancer Stage IIIKRAS P.G12C
Fundación GECP 19
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07339839
What this trial is testing

Glecirasib Combined With Ivonescimab for First-line Treatment of KRAS G12C-mutated NSCLC

Who this might be right for
NSCLC Stage IVKRAS G12C
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 42
Testing effectiveness (Phase 2)UnknownNCT05311709
What this trial is testing

Sotorasib in Advanced KRASG12C-mutated Non-small Cell Lung Cancer Patients With Comorbidities

Who this might be right for
Lung CancerNSCLC, Stage IIINSCLC Stage IV+4 more
Vestre Viken Hospital Trust 100
Testing effectiveness (Phase 2)Ended earlyNCT04165031
What this trial is testing

LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation

Who this might be right for
Advanced Solid TumorNon-Small Cell Lung CancerColorectal Cancer
Eli Lilly and Company 5
Early research (Phase 1)Looking for participantsNCT06917079
What this trial is testing

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

Who this might be right for
Non-Small Cell Lung CancerNSCLCPDAC - Pancreatic Ductal Adenocarcinoma+11 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) 387
Not applicableAvailableNCT07083479
What this trial is testing

Expanded Access Protocol of ELI-002-102 in Subjects With KRAS/NRAS Mutated Pancreatic Ductal Adenocarcinoma

Who this might be right for
Pancreatic Ductal AdenocarcinomaKRAS G12DKRAS G12V+12 more
Elicio Therapeutics
Testing effectiveness (Phase 2)WithdrawnNCT05999357
What this trial is testing

JDQ443 for KRAS G12C NSCLC Brain Metastases

Who this might be right for
Non Small Cell Lung Cancer MetastaticBrain Metastases, AdultKRAS G12C
Maastricht University Medical Center
Testing effectiveness (Phase 2)Study completedNCT05005234
What this trial is testing

GFH925 in Patients With Advanced Solid Tumors With KRAS G12C Mutations

Who this might be right for
KRAS G12C
Innovent Biologics (Suzhou) Co. Ltd. 334
Testing effectiveness (Phase 2)Active Not RecruitingNCT05194995
What this trial is testing

JAB-21822 in Combination With Cetuximab in Patients With Advanced CRC and Other Solid Tumors With KRAS G12C Mutation

Who this might be right for
Advanced Colorectal CancerSmall Intestinal CancerAppendiceal Cancer
Allist Pharmaceuticals, Inc. 48
Testing effectiveness (Phase 2)Active Not RecruitingNCT05074810
What this trial is testing

Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients

Who this might be right for
Non Small Cell Lung CancerKRAS Activating Mutation
Verastem, Inc. 153
Early research (Phase 1)Looking for participantsNCT03260491
What this trial is testing

U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer (NSCLC)
Daiichi Sankyo 309
Testing effectiveness (Phase 2)Study completedNCT05002270
What this trial is testing

JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation

Who this might be right for
Advanced Solid TumorNSCLCCRC
Jacobio Pharmaceuticals Co., Ltd. 29
Early research (Phase 1)Looking for participantsNCT06807619
What this trial is testing

Sotorasib in People With Brain Tumors

Who this might be right for
Brain Tumor
Memorial Sloan Kettering Cancer Center 16
Early research (Phase 1)Looking for participantsNCT06343402
What this trial is testing

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung CancerMetastatic Non-Small Cell Lung CancerNSCLC+3 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) 250
Testing effectiveness (Phase 2)Ended earlyNCT06024174
What this trial is testing

BMS-986466 With Adagrasib With or Without Cetuximab in Participants With Kirsten Rat Sarcoma Virus Glycine 12 to Cysteine (KRAS G12C)-Mutant Solid Tumors

Who this might be right for
Advanced Solid Tumors
Bristol-Myers Squibb 5
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