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Results for “LHON”

46 trials

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Showing 20 of 46 results

Large-scale testing (Phase 3)Study completedNCT03293524
What this trial is testing

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year

Who this might be right for
Leber Hereditary Optic Neuropathy
GenSight Biologics 98
Testing effectiveness (Phase 2)Study completedNCT02064569
What this trial is testing

Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients

Who this might be right for
Leber Hereditary Optic Neuropathy
GenSight Biologics 19
Not applicableLooking for participantsNCT03011541
What this trial is testing

Stem Cell Ophthalmology Treatment Study II

Who this might be right for
Retinal DiseaseAge-Related Macular DegenerationRetinitis Pigmentosa+15 more
MD Stem Cells 500
Early research (Phase 1)Study completedNCT01064505
What this trial is testing

Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients

Who this might be right for
Optic AtrophyNon-arteritic Anterior Ischemic Optic Neuropathy
Quark Pharmaceuticals 48
Large-scale testing (Phase 3)Active Not RecruitingNCT07406854
What this trial is testing

A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)
Wuhan Neurophth Biotechnology Limited Company 95
Not applicableStudy completedNCT04909398
What this trial is testing

Pupil Dynamics and Color Vision for the Detection of Eye Diseases

Who this might be right for
Retinitis PigmentosaLeber's Hereditary Optic NeuropathyStargardt Disease
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts 60
Early research (Phase 1)Not Yet RecruitingNCT07258667
What this trial is testing

Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic Neuropathy

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)Leber's Hereditary Optic Neuropathy (LHON)Mitochondrial Disease+1 more
University Hospital, Angers 13
Testing effectiveness (Phase 2)Looking for participantsNCT07303296
What this trial is testing

Efficacy and Safety Study of Bilateral IVT Injection of GS010 at Two Dose Levels in LHON Patients

Who this might be right for
Leber Hereditary Optic Disease
GenSight Biologics 14
Not applicableStudy completedNCT01892943
What this trial is testing

Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)
Santhera Pharmaceuticals 306
Not applicableStudy completedNCT02796274
What this trial is testing

Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic Neuropathy (LHON)

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Santhera Pharmaceuticals 219
Testing effectiveness (Phase 2)Ended earlyNCT01389817
What this trial is testing

Near-infrared Light-emitting Diode (NIR-LED) Therapy for Leber's Hereditary Optic Neuropathy (LHON)

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Medical College of Wisconsin 4
Not applicableLooking for participantsNCT05554835
What this trial is testing

Global Registry and Natural History Study for Mitochondrial Disorders

Who this might be right for
Mitochondrial DiseasesKearns-Sayre SyndromeMIDD+15 more
LMU Klinikum 6,000
Not applicableNo Longer AvailableNCT04381091
What this trial is testing

Expanded Access Program for Idebenone in Patients With Leber's Hereditary Optic Neuropathy Who Completed the LEROS Study

Who this might be right for
Leber's Hereditary Optic Neuropathy
Santhera Pharmaceuticals
Not applicableUnknownNCT03428178
What this trial is testing

Efficacy Study of Gene Therapy for The Treatment of Acute LHON Onset Within Three Months

Who this might be right for
Acute LHONOnset Within Three MonthsOnset Between 3 to 6 Months+4 more
Bin Li 120
Large-scale testing (Phase 3)Study completedNCT02652780
What this trial is testing

Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)

Who this might be right for
Optic, Atrophy, Hereditary, Leber
GenSight Biologics 37
Not applicableNo Longer AvailableNCT02300753
What this trial is testing

Emergency Administration of EPI-743 to a Single Patient With Leber's Hereditary Optic Neuropathy [LHON]

Who this might be right for
Leber's Hereditary Optic Neuropathy
Edison Pharmaceuticals Inc
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06792500
What this trial is testing

A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)

Who this might be right for
MELAS SyndromeLebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
George Washington University 24
Not applicableStudy completedNCT01267422
What this trial is testing

Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON)

Who this might be right for
Leber Hereditary Optic Neuropathy
Bin Li 9
Testing effectiveness (Phase 2)Study completedNCT02023866
What this trial is testing

Open-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial Disease

Who this might be right for
Inherited Mitochondrial Disease, Including Leigh Syndrome
Amgen 36
Testing effectiveness (Phase 2)Ended earlyNCT02473445
What this trial is testing

A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease

Who this might be right for
Mitochondrial Diseases
Amgen 22
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