Not applicableStudy completedNCT01421381What this trial is testingRHODOS Follow-up Single-visit StudyWho this might be right forLeber's Hereditary Optic Neuropathy Santhera Pharmaceuticals 60
Testing effectiveness (Phase 2)Study completedNCT02064569What this trial is testingSafety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) PatientsWho this might be right forLeber Hereditary Optic Neuropathy GenSight Biologics 19
Large-scale testing (Phase 3)UnknownNCT03153293What this trial is testingA Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic NeuropathyWho this might be right forLeber Hereditary Optic Neuropathy Huazhong University of Science and Technology 159
Not applicableNo Longer AvailableNCT03672968What this trial is testingEAP_GS010_single PatientWho this might be right forLeber Hereditary Optic Neuropathy (Optic, Atrophy, Hereditary, Leber) GenSight Biologics
Testing effectiveness (Phase 2)Study completedNCT03140969What this trial is testingStudy to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 GeneWho this might be right forLeber's Congenital Amaurosis Laboratoires Thea 11
Large-scale testing (Phase 3)Study completedNCT03293524What this trial is testingEfficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 YearWho this might be right forLeber Hereditary Optic Neuropathy GenSight Biologics 98
Early research (Phase 1)Study completedNCT01064505What this trial is testingSafety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION PatientsWho this might be right forOptic AtrophyNon-arteritic Anterior Ischemic Optic Neuropathy Quark Pharmaceuticals 48
Large-scale testing (Phase 3)Active Not RecruitingNCT07406854What this trial is testingA Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 MutationWho this might be right forLeber Hereditary Optic Neuropathy (LHON) Wuhan Neurophth Biotechnology Limited Company 95
Testing effectiveness (Phase 2)UnknownNCT02176733What this trial is testingTrial of Cyclosporine in the Acute Phase of Leber Hereditary Optic NeuropathyWho this might be right forLeber Hereditary Optic Neuropathy University Hospital, Angers 12
Not applicableStudy completedNCT04909398What this trial is testingPupil Dynamics and Color Vision for the Detection of Eye DiseasesWho this might be right forRetinitis PigmentosaLeber's Hereditary Optic NeuropathyStargardt Disease Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts 60
Testing effectiveness (Phase 2)Study completedNCT00747487What this trial is testingStudy to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic NeuropathyWho this might be right forLeber's Hereditary Optic Neuropathy Santhera Pharmaceuticals 85
Not applicableEnrolling By InvitationNCT03655223What this trial is testingEarly Check: Expanded Screening in NewbornsWho this might be right forSpinal Muscular AtrophyFragile X SyndromeFragile X - Premutation+182 more RTI International 30,000
Not applicableStudy completedNCT01892943What this trial is testingLeber Hereditary Optic Neuropathy (LHON) Historical Case Record SurveyWho this might be right forLeber Hereditary Optic Neuropathy (LHON) Santhera Pharmaceuticals 306
Testing effectiveness (Phase 2)Study completedNCT02023866What this trial is testingOpen-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial DiseaseWho this might be right forInherited Mitochondrial Disease, Including Leigh Syndrome Amgen 36
Not applicableLooking for participantsNCT03475173What this trial is testingNew Non-invasive Modalities for Assessing Retinal Structure and FunctionWho this might be right forIschemic Optic NeuropathyBranch Retinal Artery OcclusionHemianopia+2 more Randy Kardon 500
Not applicableStudy completedNCT01267422What this trial is testingSafety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON)Who this might be right forLeber Hereditary Optic Neuropathy Bin Li 9
Large-scale testing (Phase 3)Study completedNCT00528151What this trial is testingA Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON)Who this might be right forOptic Atrophy, Hereditary, Leber Mahidol University 70
Early research (Phase 1)Not Yet RecruitingNCT07258667What this trial is testingPilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic NeuropathyWho this might be right forLeber Hereditary Optic Neuropathy (LHON)Leber's Hereditary Optic Neuropathy (LHON)Mitochondrial Disease+1 more University Hospital, Angers 13
Testing effectiveness (Phase 2)Looking for participantsNCT06792500What this trial is testingA Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)Who this might be right forMELAS SyndromeLebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) George Washington University 24
Not applicableLooking for participantsNCT06682819What this trial is testingMetabolomics Analysis According to the Retinal Nerve Fiber Layer in Patients With NOHL Mutations (MétabOCT)Who this might be right forHealthy SubjectsLeber Hereditary Optic Neuropathy Hôpital Necker-Enfants Malades 90