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Results for “Leptomeningeal Carcinomatosis”

150 trials

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Showing 20 of 150 results

Early research (Phase 1)Active Not RecruitingNCT04192981
What this trial is testing

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

Who this might be right for
Brain MetastasesLeptomeningeal Metastasis
Memorial Sloan Kettering Cancer Center 21
Testing effectiveness (Phase 2)Looking for participantsNCT06728865
What this trial is testing

Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)EGFR Mutation-Positive Lung CancerBrain Metastases+2 more
Li-kun Chen 70
Not applicableStudy completedNCT07239102
What this trial is testing

Firmonertinib in the Treatment of EGFR(+) NSCLC Patients With Central Nervous System Metastasis

Who this might be right for
EGFR Positive Non-small Cell Lung CancerCentral Nervous System MetastasisLeptomeningeal Metastasis
Beijing Tiantan Hospital 300
Testing effectiveness (Phase 2)Looking for participantsNCT06901817
What this trial is testing

The Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Shanghai Cancer Hospital, China 97
Early research (Phase 1)Active Not RecruitingNCT06724926
What this trial is testing

Concurrent Azeliragon With Craniospinal Irradiation

Who this might be right for
Solid TumorHigh-grade GliomaLeptomeningeal Metastasis
NYU Langone Health 21
Testing effectiveness (Phase 2)UnknownNCT01818713
What this trial is testing

Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases

Who this might be right for
Meningeal Carcinomatosis
The Netherlands Cancer Institute 6
Not applicableUnknownNCT02803619
What this trial is testing

A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis

Who this might be right for
Non-small Cell Lung CancerLeptomeningeal Metastasis
Peking Union Medical College Hospital 60
Testing effectiveness (Phase 2)UnknownNCT05813522
What this trial is testing

Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC

Who this might be right for
Non Small Cell Lung Cancer
First Affiliated Hospital of Zhejiang University 30
Testing effectiveness (Phase 2)Looking for participantsNCT06296745
What this trial is testing

Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.

Who this might be right for
Leptomeningeal Metastasis
Guangzhou Medical University 36
Early research (Phase 1)Ended earlyNCT00112619
What this trial is testing

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Who this might be right for
Brain and Central Nervous System TumorsCarcinoma of Unknown PrimaryLeukemia+2 more
Pediatric Brain Tumor Consortium 19
Not applicableLooking for participantsNCT06718972
What this trial is testing

A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China

Who this might be right for
Meningeal MetastasisNon-Small Cell Lung Cancer
Guangzhou Medical University 1,000
Early research (Phase 1)Active Not RecruitingNCT05034497
What this trial is testing

Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Cerenome 18
Not applicableLooking for participantsNCT07398599
What this trial is testing

Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study

Who this might be right for
Leptomeningeal MetastasisLung Neoplasms, Non-Small Cell Lung Cancer
Second Affiliated Hospital of Nanchang University 30
Early research (Phase 1)WithdrawnNCT00210340
What this trial is testing

A Phase I Study of Intrathecal Rituximab in Patients With Lymphomatous Meningitis

Who this might be right for
Lymphoma, B Cell
International Extranodal Lymphoma Study Group (IELSG)
Early research (Phase 1)Study completedNCT02423525
What this trial is testing

Safety Study of Afatinib for Brain Cancer

Who this might be right for
Brain Cancer
Santosh Kesari 24
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06861218
What this trial is testing

Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastases
Zhejiang Cancer Hospital 42
Not applicableLooking for participantsNCT05746754
What this trial is testing

Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis
University of Aarhus 50
Early research (Phase 1)Not Yet RecruitingNCT07674693
What this trial is testing

Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastases
NYU Langone Health 29
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07833657
What this trial is testing

Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal MetastasesSolid Tumors
Jiuda Zhao 28
Post-approval studies (Phase 4)Looking for participantsNCT07092202
What this trial is testing

Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases

Who this might be right for
Leptomeningeal MetastasisNSCLCIntrathecal Chemotherapy+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 40
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