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Results for “Leptomeningeal Disease (LMD)”

9 trials

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Showing 9 of 9 results

Early research (Phase 1)Looking for participantsNCT03423628
What this trial is testing

Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Who this might be right for
Recurrent Glioblastoma MultiformePrimary Glioblastoma MultiformeBrain Neoplasms, Malignant+1 more
AstraZeneca 180
Early research (Phase 1)Looking for participantsNCT03025256
What this trial is testing

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

Who this might be right for
Acral Lentiginous MelanomaCentral Nervous System MelanomaClinical Stage IV Cutaneous Melanoma AJCC v8+7 more
M.D. Anderson Cancer Center 75
Early research (Phase 1)Ended earlyNCT03711422
What this trial is testing

Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC

Who this might be right for
Non-small Cell Lung CancerLeptomeningeal DiseaseCentral Nervous System Metastases
National Cancer Centre, Singapore 2
Not applicableLooking for participantsNCT07476781
What this trial is testing

CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases

Who this might be right for
Solid Tumor MalignanciesBrain MetastasasesLeptomeningeal Disease (LMD)
Sunnybrook Health Sciences Centre 60
Testing effectiveness (Phase 2)Looking for participantsNCT06016387
What this trial is testing

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

Who this might be right for
HER2-positive Breast CancerLMD
Sunnybrook Health Sciences Centre 30
Testing effectiveness (Phase 2)Ended earlyNCT03501979
What this trial is testing

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

Who this might be right for
Metastatic Breast CancerLeptomeningeal Disease
University of Alabama at Birmingham 17
Testing effectiveness (Phase 2)Ended earlyNCT01596127
What this trial is testing

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

Who this might be right for
LeukemiaLymphoid MalignanciesMetastatic Malignant Neoplasm to the Leptomeninges
M.D. Anderson Cancer Center 4
Early research (Phase 1)Active Not RecruitingNCT05809752
What this trial is testing

A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)

Who this might be right for
Leptomeningeal DiseaseTriple Negative Breast CancerHER2-positive Breast Cancer
H. Lee Moffitt Cancer Center and Research Institute 15
Testing effectiveness (Phase 2)Active Not RecruitingNCT05305365
What this trial is testing

Study Assessing QBS72S For Treating Brain Metastases

Who this might be right for
Brain MetastasesBreast CancerLung Cancer+2 more
Stanford University 21