Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Leptomeningeal Metastases”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Early research (Phase 1)Study completedNCT00416923
What this trial is testing

Intrathecal Rituximab in Treating Patients With Recurrent CNS Lymphoma

Who this might be right for
Brain and Central Nervous System TumorsLymphoma
University of California, San Francisco 10
Early research (Phase 1)WithdrawnNCT07199413
What this trial is testing

Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy

Who this might be right for
Brain MetastasesLeptomeningeal Metastasis
Medical College of Wisconsin
Not applicableUnknownNCT04944069
What this trial is testing

Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal Metastasis

Who this might be right for
NSCLCLeptomeningeal MetastasisEGFR Activating Mutation
Second Affiliated Hospital of Nanchang University 69
Testing effectiveness (Phase 2)Study completedNCT02616393
What this trial is testing

Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases

Who this might be right for
Non-Small Cell Lung CancerLeptomeningeal MetastasesBrain Metastases
Kadmon Corporation, LLC 36
Early research (Phase 1)Ended earlyNCT01563614
What this trial is testing

A Clinical Trial to Assess the Safety & Efficacy of the Treatment of Patients With Metastasis From Malignant Melanoma - Treatment Consists of the Substances Lomustine (Capsules) & Cytarabine (Injected Into an Area Near the Spinal Cord), Accompanied by Radiotherapy of the Brain

Who this might be right for
Leptomeningeal Metastasis From Malignant Melanoma
University Hospital, Bonn 1
Testing effectiveness (Phase 2)Looking for participantsNCT05805631
What this trial is testing

Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC

Who this might be right for
Carcinoma, Non-Small-Cell LungEpidermal Growth Factor ReceptorLeptomeningeal Metastasis
Taipei Veterans General Hospital, Taiwan 23
Testing effectiveness (Phase 2)Study completedNCT01325207
What this trial is testing

Intrathecal Trastuzumab for Leptomeningeal Metastases in HER2+ Breast Cancer

Who this might be right for
Breast Cancer
Northwestern University 34
Early research (Phase 1)Active Not RecruitingNCT03696030
What this trial is testing

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Who this might be right for
Malignant NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges+2 more
City of Hope Medical Center 24
Post-approval studies (Phase 4)Looking for participantsNCT07092202
What this trial is testing

Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases

Who this might be right for
Leptomeningeal MetastasisNSCLCIntrathecal Chemotherapy+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 40
Testing effectiveness (Phase 2)UnknownNCT04833205
What this trial is testing

Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer

Who this might be right for
Leptomeningeal MetastasisLung Cancer
Hui Bu 30
Early research (Phase 1)Study completedNCT01654497
What this trial is testing

Dexanabinol in Patients With Brain Cancer

Who this might be right for
Brain Cancer
Santosh Kesari, M.D., Ph.D. 26
Testing effectiveness (Phase 2)Looking for participantsNCT07559097
What this trial is testing

Exploration of the Application of Methotrexate-loaded Drug Vesicles in Intrathecal Injection for Meningeal Metastasis of Lung Cancer

Who this might be right for
Leptomeningeal Metastasis From Lung Cancer
Henan Cancer Hospital 14
Early research (Phase 1)Study completedNCT00002750
What this trial is testing

Melphalan in Patients With Neoplastic Meningitis

Who this might be right for
Brain and Central Nervous System TumorsExtragonadal Germ Cell TumorLeukemia+2 more
Duke University 6
Testing effectiveness (Phase 2)Study completedNCT04343573
What this trial is testing

Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors

Who this might be right for
Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center 102
Testing effectiveness (Phase 2)Looking for participantsNCT05800275
What this trial is testing

Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease

Who this might be right for
Leptomeningeal MetastasisLeptomeningeal DiseaseHER2-positive Metastatic Breast Cancer
UNICANCER 30
Early research (Phase 1)Active Not RecruitingNCT05598853
What this trial is testing

Intrathecal Double Checkpoint Inhibition

Who this might be right for
Leptomeningeal MetastasisNon-small Cell Lung Cancer Stage IVMelanoma Stage IV
University of Zurich 26
Early research (Phase 1)Active Not RecruitingNCT05034497
What this trial is testing

Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Cerenome 18
Early research (Phase 1)Study completedNCT02253264
What this trial is testing

Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients

Who this might be right for
Primary Progressive Multiple SclerosisSecondary Progressive Multiple Sclerosis
Johns Hopkins University 8
Testing effectiveness (Phase 2)Study completedNCT06812871
What this trial is testing

High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis

Who this might be right for
Non-small Cell Lung Cancer Metastatic
Sun Yat-sen University 46
Testing effectiveness (Phase 2)Looking for participantsNCT06462092
What this trial is testing

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

Who this might be right for
Leptomeningeal Metastases
Guangzhou Medical University 34
Next Page