Not applicableEnded earlyNCT00964743What this trial is testingDepocyt® With Sorafenib in Neoplastic MeningitisWho this might be right forNeoplastic Meningitis H. Lee Moffitt Cancer Center and Research Institute 2
Testing effectiveness (Phase 2)Looking for participantsNCT06016387What this trial is testingTucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility StudyWho this might be right forHER2-positive Breast CancerLMD Sunnybrook Health Sciences Centre 30
Not applicableLooking for participantsNCT05746325What this trial is testingTumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung CancerWho this might be right forAnatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Leptomeninges+2 more Mayo Clinic 5
Not applicableStudy completedNCT05286684What this trial is testingFeasibility of Exosome Analysis in Cerebrospinal Fluid During the Diagnostic Workup of Metastatic MeningitisWho this might be right forBreast Cancer Centre Oscar Lambret 7
Large-scale testing (Phase 3)Study completedNCT01645839What this trial is testingInterest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast CancerWho this might be right forBreast CancerLeptomeningeal Metastases Centre Oscar Lambret 74
Not applicableEnded earlyNCT05414123What this trial is testingA Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSideWho this might be right forLeptomeningeal MetastasisLeptomeningeal DiseaseLeptomeningeal Neoplasms+2 more Biocept, Inc. 40
Testing effectiveness (Phase 2)Study completedNCT01281696What this trial is testingBevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal MetastasisWho this might be right forBreast NeoplasmsLeptomeningeal MetastasisBrain Metastases National Taiwan University Hospital 40
Early research (Phase 1)Study completedNCT00005842What this trial is testingTrastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic CancerWho this might be right forCancer National Cancer Institute (NCI) 24
Testing effectiveness (Phase 2)Study completedNCT04420598What this trial is testingDS-8201a for trEatment of aBc, BRain Mets, And Her2[+] DiseaseWho this might be right forAdvanced Breast CancerHER2-positive Breast CancerBrain Metastases+1 more MedSIR 41
Testing effectiveness (Phase 2)Study completedNCT01373710What this trial is testingIntrathecal Trastuzumab Administration in Metastatic Breast Cancer Patients Developing Carcinomatous MeningitisWho this might be right forMetastatic Breast CancerCarcinomatous Meningitis Institut Curie 34
Not applicableStudy completedNCT07386886What this trial is testingDevelopment of a Novel Graded Prognostic Assessment (BC-LGPA) Model for Breast Cancer Leptomeningeal MetastasisWho this might be right forLeptomeningeal Metastasis in Breast Cancer Jian Zhang,MD 403
Post-approval studies (Phase 4)Looking for participantsNCT06230055What this trial is testingIntrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal MetastasisWho this might be right forHER2-negative Breast CancerLeptomeningeal Metastasis Fudan University 37
Not applicableStudy completedNCT03252912What this trial is testingStudy in Leptomeningeal Metastases of Breast CancerWho this might be right forBreast Cancer Institut du Cancer de Montpellier - Val d'Aurelle 51
Early research (Phase 1)Active Not RecruitingNCT03696030What this trial is testingHER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal MetastasesWho this might be right forMalignant NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges+2 more City of Hope Medical Center 24
Testing effectiveness (Phase 2)Looking for participantsNCT06518057What this trial is testingHippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung CancerWho this might be right forAnatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+2 more University of Washington 22
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07177950What this trial is testingA Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain MetastasesWho this might be right forBreast CancerBrain MetastasesLeptomeningeal Metastasis Peking University Cancer Hospital & Institute 51
Testing effectiveness (Phase 2)Looking for participantsNCT02422641What this trial is testingProspective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal MetastasisWho this might be right forMetastatic Breast CancerLeptomeningeal Disease Wake Forest University Health Sciences 16
Testing effectiveness (Phase 2)Looking for participantsNCT06910761What this trial is testingPhoton Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung CancerWho this might be right forAnatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+2 more City of Hope Medical Center 35
Not applicableUnknownNCT00938756What this trial is testingStudy of Cerebrospinal Fluid Samples in Diagnosing Carcinomatous Meningitis in Patients With Cancer or Meningeal SyndromeWho this might be right forBrain and Central Nervous System TumorsBreast CancerMetastatic Cancer Centre Oscar Lambret 80
Testing effectiveness (Phase 2)Active Not RecruitingNCT04588545What this trial is testingRadiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal DiseaseWho this might be right forHER2-positive Breast CancerLeptomeningeal MetastasisLeptomeningeal Disease H. Lee Moffitt Cancer Center and Research Institute 33