Early research (Phase 1)Study completedNCT02423525What this trial is testingSafety Study of Afatinib for Brain CancerWho this might be right forBrain Cancer Santosh Kesari 24
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06861218What this trial is testingCerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal MetastasesWho this might be right forLeptomeningeal Metastases Zhejiang Cancer Hospital 42
Not applicableActive Not RecruitingNCT06926803What this trial is testingA Clinical Study of Furmonertinib in the Treatment of EGFR-Mutated NSCLC With Leptomeningeal MetastasesWho this might be right forLung Cancer (NSCLC)Leptomeningeal Cancer Qiming Wang 500
Not applicableLooking for participantsNCT05746754What this trial is testingProton Cranio-spinal Irradiation for Leptomeningeal MetastasisWho this might be right forLeptomeningeal Metastasis University of Aarhus 50
Early research (Phase 1)Not Yet RecruitingNCT07674693What this trial is testingPhase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal MetastasesWho this might be right forLeptomeningeal Metastases NYU Langone Health 29
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07833657What this trial is testingCombined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal MetastasesWho this might be right forLeptomeningeal MetastasesSolid Tumors Jiuda Zhao 28
Post-approval studies (Phase 4)Looking for participantsNCT07092202What this trial is testingFirmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal MetastasesWho this might be right forLeptomeningeal MetastasisNSCLCIntrathecal Chemotherapy+1 more Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 40
Testing effectiveness (Phase 2)Looking for participantsNCT05800275What this trial is testingCapecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal DiseaseWho this might be right forLeptomeningeal MetastasisLeptomeningeal DiseaseHER2-positive Metastatic Breast Cancer UNICANCER 30
Early research (Phase 1)Looking for participantsNCT05112549What this trial is testingIntrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)Who this might be right forLeptomeningeal Disease University Hospital Tuebingen 46
Not applicableUnknownNCT04778800What this trial is testingA Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)Who this might be right forNSCLCBrain MetastasesLeptomeningeal Metastasis Henan Cancer Hospital 60
Large-scale testing (Phase 3)UnknownNCT03613181What this trial is testingANG1005 in Leptomeningeal Disease From Breast CancerWho this might be right forLeptomeningeal CarcinomatosisLeptomeningeal MetastasesBrain Metastases+1 more Angiochem Inc 150
Testing effectiveness (Phase 2)Study completedNCT04343573What this trial is testingProton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid TumorsWho this might be right forLeptomeningeal Metastases Memorial Sloan Kettering Cancer Center 102
Post-approval studies (Phase 4)Active Not RecruitingNCT06282874What this trial is testingLorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal MetastasesWho this might be right forCarcinoma, Non-Small-Cell LungBrain MetastasesLeptomeningeal Metastasis Guangdong Association of Clinical Trials 41
Testing effectiveness (Phase 2)Study completedNCT04563871What this trial is testingEfficacy and Safety of 80mg Osimertinib in Patients With Non-small Cell Lung Cancer(NSCLC)Who this might be right forNon-small Cell Lung Cancer (NSCLC) Sehhoon Park 73
Not applicableStudy completedNCT01713699What this trial is testingCirculating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal MetastasesWho this might be right forMeningeal Carcinomatosis The Netherlands Cancer Institute 146
Testing effectiveness (Phase 2)Ended earlyNCT00830245What this trial is testingAssess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung CancerWho this might be right forLeptomeningeal CarcinomatosisNon-small Cell Lung Cancer Clinical Research Center for Solid Tumor, Korea 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07789912What this trial is testingBRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor MalignanciesWho this might be right forLeptomeningeal MetastasisBreast CancerLung Cancer (NSCLC) University of Miami 40
Early research (Phase 1)Active Not RecruitingNCT04661384What this trial is testingBrain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or MedulloblastomaWho this might be right forEpendymomaGlioblastomaMedulloblastoma+1 more City of Hope Medical Center 10
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07778940What this trial is testingThiotepa Administration Via Ommaya Reservoir for Leptomeningeal Metastases in Non-Small Cell Lung Cancer Resistant to EGFR-TKI.Who this might be right forLeptomeningeal Metastasis Tianjin Medical University Cancer Institute and Hospital 50
Not applicableStudy completedNCT02071056What this trial is testingCirculating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM)Who this might be right forLeptomeningeal Metastasis Dartmouth-Hitchcock Medical Center 5