Not applicableLooking for participantsNCT06726642What this trial is testingCfDNA in Hereditary And High-risk Malignancies 2Who this might be right forHereditary Cancer Syndrome University Health Network, Toronto 1,000
Not applicableStudy completedNCT07032922What this trial is testingExploring How to Adapt an Evidence-Based Mindful Self-Compassion Program for Young Adults With Li-Fraumeni SyndromeWho this might be right forLi-Fraumeni Syndrome National Cancer Institute (NCI) 7
Not applicableLooking for participantsNCT06888388What this trial is testingLong-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast CancerWho this might be right forBreast Cancer Surgery Sir Mortimer B. Davis - Jewish General Hospital 4,700
Not applicableStudy completedNCT04966923What this trial is testingPhenotype and Prognosis of Patients With Breast Cancer and Pathogenic Variants of TP53Who this might be right forBreast CancerTP53 R337HLi-Fraumeni Syndrome+1 more Instituto do Cancer do Estado de São Paulo 135
Not applicableLooking for participantsNCT01143454What this trial is testingCharacterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular SystemWho this might be right forMetabolic DiseaseObesityLi-Fraumeni Syndrome+3 more National Heart, Lung, and Blood Institute (NHLBI) 5,000
Not applicableLooking for participantsNCT04982744What this trial is testingRegistry of Li Fraumeni and Li Fraumeni Like SyndromesWho this might be right forLi-Fraumeni SyndromeLi-Fraumeni-Like Syndrome Istituto Ortopedico Rizzoli 200
Not applicableStudy completedNCT00040222What this trial is testingClinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian CancerWho this might be right forFamilial Ovarian CancerFamilial Breast CancerBRCA1-associate Malignancies+1 more National Cancer Institute (NCI) 377
Not applicableActive Not RecruitingNCT02950987What this trial is testingScreening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition SyndromesWho this might be right forLi-Fraumeni Syndrome Dana-Farber Cancer Institute 150
Not applicableUnknownNCT06163365What this trial is testingInherited Cancer Early Diagnosis (ICED) StudyWho this might be right forLi Fraumeni SyndromeLynch SyndromeHereditary Diffuse Gastric Cancer+5 more Royal Marsden NHS Foundation Trust 100
Not applicableLooking for participantsNCT06523582What this trial is testingGenetic Bases of Neuroendocrine Neoplasms in Mexican PatientsWho this might be right forNeuroendocrine NeoplasmNeuroendocrine Neoplasm of Gastrointestinal TractNeuroendocrine Neoplasm of Lung+23 more Universidad Nacional Autonoma de Mexico 750
Large-scale testing (Phase 3)Study completedNCT01464086What this trial is testingLIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)Who this might be right forLi Fraumeni Syndrome Gustave Roussy, Cancer Campus, Grand Paris 107
Early research (Phase 1)Study completedNCT01981525What this trial is testingA Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni SyndromeWho this might be right forLi-Fraumeni Syndrome National Cancer Institute (NCI) 26
Not applicableLooking for participantsNCT01443468What this trial is testingClinical and Genetic Studies of Li-Fraumeni SyndromeWho this might be right forLi-Fraumeni SyndromeNeoplasmsTp53 Mutations National Cancer Institute (NCI) 5,000
Not applicableLooking for participantsNCT04367246What this trial is testingLi-Fraumeni Syndrome/TP53 BiobankWho this might be right forLi-Fraumeni SyndromeLi-Fraumeni-Like Syndrome Abramson Cancer Center at Penn Medicine 300
Not applicableLooking for participantsNCT06712095What this trial is testingVideo Capsule Examination in Patients With Lynch SyndromeWho this might be right forLynch SyndromeLi Fraumeni SyndromePTEN Hamartoma Syndrome+7 more Royal Marsden NHS Foundation Trust 25
Testing effectiveness (Phase 2)Looking for participantsNCT06088030What this trial is testingArsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric CancerWho this might be right forPediatric CancerLi-Fraumeni Syndromep53 Mutations Yang Li 50
Not applicableLooking for participantsNCT05126810What this trial is testingWillingness to Participate in a Trial Comparing Standard Genetic Counseling Versus Personalized Genetic CounselingWho this might be right forLi-Fraumeni Syndrome M.D. Anderson Cancer Center 500
Not applicableLooking for participantsNCT03050268What this trial is testingFamilial Investigations of Childhood Cancer PredispositionWho this might be right forAcute LeukemiaAdenomatous PolyposisAdrenocortical Carcinoma+43 more St. Jude Children's Research Hospital 1,500
Not applicableStudy completedNCT02289326What this trial is testingBiomarker Monitoring in TP53 Mutation CarriersWho this might be right forLi-Fraumeni SyndromeHereditary Cancer SyndromesTP53 Gene Germline Mutation Carrier Scripps Health 6
Not applicableNot Yet RecruitingNCT07005297What this trial is testingClinical Genetics Branch Eligibility Screening SurveyWho this might be right forMelanomaLi-Fraumeni SyndromePulmonary Blastoma+7 more National Cancer Institute (NCI) 1,000