Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Locally Advanced”

6,211 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 6,211 results

Testing effectiveness (Phase 2)Looking for participantsNCT04165772
What this trial is testing

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Who this might be right for
Rectal AdenocarcinomaClinical Stage: Stage II (T3-4, N-)Stage III (Any T, N+)+2 more
Memorial Sloan Kettering Cancer Center 200
Testing effectiveness (Phase 2)Ended earlyNCT03735095
What this trial is testing

Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer

Who this might be right for
Locally Advanced Lung CarcinomaNon-Small Cell Lung CarcinomaSmall Cell Lung Carcinoma+5 more
Roswell Park Cancer Institute 19
Testing effectiveness (Phase 2)Ended earlyNCT05678257
What this trial is testing

NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer

Who this might be right for
Colorectal CancerColorectal NeoplasmsColorectal Adenocarcinoma+2 more
NuCana plc 180
Testing effectiveness (Phase 2)Looking for participantsNCT06467565
What this trial is testing

NALIRIFOX as Induction Therapy in LAPC

Who this might be right for
Pancreatic Ductal Adenocarcinoma
The First Affiliated Hospital with Nanjing Medical University 20
Testing effectiveness (Phase 2)Study completedNCT01093222
What this trial is testing

Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma

Who this might be right for
Extrahepatic Bile Duct AdenocarcinomaGallbladder AdenocarcinomaGallbladder Adenocarcinoma With Squamous Metaplasia+6 more
National Cancer Institute (NCI) 40
Post-approval studies (Phase 4)Study completedNCT03610022
What this trial is testing

Relationship Between Pharmacokinetics and Safety of Vismodegib - OPTIVISMO-1

Who this might be right for
Metastatic Basal Cell CarcinomaLocally Advanced Basal Cell Carcinoma
University Hospital, Bordeaux 27
Early research (Phase 1)Study completedNCT05327231
What this trial is testing

IN10018 Monotherapy or in Combination With Docetaxel in Gastric or GEJ Adenocarcinoma

Who this might be right for
Gastric Cancer
InxMed (Shanghai) Co., Ltd. 33
Large-scale testing (Phase 3)Not Yet RecruitingNCT07442565
What this trial is testing

SYS6010 Versus Docetaxel for Previously Treated EGFR Wild-type NSCLC: Phase Ⅲ

Who this might be right for
Non-Small Cell Lung Cancer
CSPC Megalith Biopharmaceutical Co.,Ltd. 506
Large-scale testing (Phase 3)Not Yet RecruitingNCT06980545
What this trial is testing

Total Neoadjuvant 6 Cycles of Chemotherapy Versus 3 Cycles in Partial Responder Patients Diagnosed With Epithelial Ovarian Cancer

Who this might be right for
Stage III and IV Ovarian Cancer
Assiut University 50
Not applicableUnknownNCT04273477
What this trial is testing

Radiomics-based Artificial Intelligence System to Predict Neoadjuvant Treatment Response in Rectal Cancer

Who this might be right for
Rectal Cancer
Sixth Affiliated Hospital, Sun Yat-sen University 100
Testing effectiveness (Phase 2)UnknownNCT04152057
What this trial is testing

Pyrotinib Maleate Tablets Combined With Albumin Paclitaxel and Trastuzumab for Her2-positive Breast Cancer

Who this might be right for
Breast CancerHER2 PositiveCombination Chemotherapy
West China Hospital 20
Testing effectiveness (Phase 2)Looking for participantsNCT06698757
What this trial is testing

Different Cycles of Preoperative Neoadjuvant Sintilimab in Mismatch-repair Deficient/microsatellite Instability-high, Locally Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer
Yugui Lian 96
Large-scale testing (Phase 3)Looking for participantsNCT06791512
What this trial is testing

MFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC

Who this might be right for
Colorectal Cancer (CRC)pMMR/MSS Adenocarcinoma of the Colon or Rectum
Jun Huang 166
Testing effectiveness (Phase 2)Study completedNCT01260181
What this trial is testing

Erlotinib in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations

Who this might be right for
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT04301557
What this trial is testing

PD1 Antibody Toripalimab and Chemoradiotherapy for dMMR/MSI-H Locally Advanced Colorectal Cancer

Who this might be right for
DMMR Colorectal CancerMSI-H Colorectal CancerLocally Advanced Colorectal Cancer
Sun Yat-sen University 25
Testing effectiveness (Phase 2)Study completedNCT00951665
What this trial is testing

Trastuzumab Emtansine, Paclitaxel, and Pertuzumab in Patients With HER2-Positive, Locally Advanced or Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Genentech, Inc. 107
Large-scale testing (Phase 3)Study completedNCT01626222
What this trial is testing

4EVER - Efficacy, Safety, Health Economics, Translational Research of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Novartis Pharmaceuticals 301
Testing effectiveness (Phase 2)Looking for participantsNCT07286253
What this trial is testing

QL1706 Plus Chemotherapy as Neoadjuvant Therapy for Locally Advanced Cervical Cancer: A Phase II Trial

Who this might be right for
Neoadjuvant Treatment for Locally Advanced Cervical Cancer
Affiliated Cancer Hospital & Institute of Guangzhou Medical University 50
Testing effectiveness (Phase 2)Study completedNCT03092934
What this trial is testing

AK-01 (LY3295668) in Solid Tumors

Who this might be right for
NeoplasmsNeoplasm MetastasisTriple Negative Breast Neoplasms+4 more
Eli Lilly and Company 13
Testing effectiveness (Phase 2)UnknownNCT05732493
What this trial is testing

Short-course Radiotherapy Combined With Chemotherapy and Pd-1 Inhibitor for Locally Advanced Colon Cancer(TORCH-C)

Who this might be right for
Locally Advanced Colon Cancer
Fudan University 120
Load More Results