Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Locally Advanced Stage”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT05230810
What this trial is testing

Clinical Trial of Alpelisb and Tucatinib in Patients With PIK3CA-Mutant HER2+ Metastatic Breast Cancer.

Who this might be right for
HER2-positive Metastatic Breast Cancer
Criterium, Inc. 40
Large-scale testing (Phase 3)Looking for participantsNCT06081959
What this trial is testing

Study of SKB264 for Locally Advanced, Recurrent or Metastatic HR+/HER2- Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 376
Testing effectiveness (Phase 2)Study completedNCT04184921
What this trial is testing

Combination of Osimertinib and Aspirin to Treat EGFR Mutation NSCLC Patients

Who this might be right for
Lung Cancer Non-small Cell Stage IV
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 216
Testing effectiveness (Phase 2)Looking for participantsNCT07162506
What this trial is testing

DCRT vs. Surgery in Resectable ESCC Patient Achiving cCR/PR After nCI

Who this might be right for
Esophageal Cancer
Tianjin Medical University Cancer Institute and Hospital 120
Testing effectiveness (Phase 2)UnknownNCT01993784
What this trial is testing

Study of Nimotuzumab to Treat Esophageal Squamous Cell Carcinoma.

Who this might be right for
Esophageal Squamous Cell Cancer
Peking University 9
Testing effectiveness (Phase 2)UnknownNCT05420584
What this trial is testing

Neoadjuvant Arterial Embolization Chemotherapy Combined PD-1 Inhibitor for Locally Advanced Rectal Cancer

Who this might be right for
Rectal Neoplasms
The Fourth Affiliated Hospital of Zhejiang University School of Medicine 83
Testing effectiveness (Phase 2)Study completedNCT00623233
What this trial is testing

Gemcitabine Plus Bevacizumab in Locally Recurrent or Metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerLocally Advanced Breast Cancer
Eli Lilly and Company 52
Testing effectiveness (Phase 2)Looking for participantsNCT07061704
What this trial is testing

Oncolytic Virus in Esophageal Squamous Cell Carcinoma

Who this might be right for
Esophageal Cancer
Sichuan University 40
Testing effectiveness (Phase 2)Study completedNCT02289833
What this trial is testing

Trastuzumab Emtansine in Participants With Human Epidermal Growth Factor Receptor (HER)2 Immunohistochemistry (IHC)-Positive, Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Who this might be right for
Non-Small Cell Lung Cancer
Hoffmann-La Roche 49
Large-scale testing (Phase 3)Looking for participantsNCT07662395
What this trial is testing

SCTB41 Combined With Chemotherapy in Advanced Squamous Non-Small Cell Lung Cancer

Who this might be right for
Double Blind
Sinocelltech Ltd. 410
Early research (Phase 1)Study completedNCT01562275
What this trial is testing

A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0973 in Combination With GDC-0068 When Administered in Participants With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Neoplasms
Genentech, Inc. 67
Early research (Phase 1)Study completedNCT02058381
What this trial is testing

A Phase Ib Dose De-escalation Study With BYL719 in Premenopausal Patients With Locally Advanced or Metastatic Breast Cancer

Who this might be right for
Pre-menopausal Breast CancerPI3K Pathway Inhibition
Novartis Pharmaceuticals 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT05888844
What this trial is testing

Evaluate INCB099280 in Participants With Advanced Cutaneous Squamous Cell Carcinoma

Who this might be right for
Cutaneous Squamous Cell Carcinoma
Incyte Corporation 63
Early research (Phase 1)Ended earlyNCT01086332
What this trial is testing

Evaluation of Nelfinavir and Chemoradiation for Pancreatic Cancer

Who this might be right for
Pancreatic Neoplasms
University of Iowa 7
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07307287
What this trial is testing

SHR-A1811 Plus Pertuzumab as Neoadjuvant Therapy for Early or Locally Advanced HR-Positive HER2-Positive Breast Cancer: A Prospective, Open-Label, Phase II Study

Who this might be right for
SHR-A1811HER2-Postive Breast CancerHR+ Breast Cancer+2 more
Tianjin Medical University Cancer Institute and Hospital 30
Testing effectiveness (Phase 2)UnknownNCT03460275
What this trial is testing

Osimertinib as First-line Therapy for Patients With Late-stage Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
Sun Yat-sen University 100
Large-scale testing (Phase 3)Looking for participantsNCT07155187
What this trial is testing

Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
AbbVie 490
Early research (Phase 1)Study completedNCT02650713
What this trial is testing

The Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors

Who this might be right for
Solid Tumors
Hoffmann-La Roche 228
Testing effectiveness (Phase 2)Active Not RecruitingNCT04910347
What this trial is testing

Consolidation Nivolumab After Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma

Who this might be right for
Locally Advanced Nasopharyngeal Carcinoma
Yonsei University 57
Testing effectiveness (Phase 2)Ended earlyNCT02291055
What this trial is testing

ADXS11-001 or MEDI4736 Alone or Combination In Cervical or Human Papillomavirus (HPV)+ Head & Neck Cancer

Who this might be right for
Cervical CancerCancerHead and Neck Cancer
Advaxis, Inc. 75
Next Page