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Results for “Locally Advanced or Metastatic CRC”

142 trials

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Showing 20 of 142 results

Not applicableStudy completedNCT00097578
What this trial is testing

Avastin With Chemotherapy for Treatment of Metastatic or Advanced and Unresectable Colorectal Adenocarcinoma

Who this might be right for
Colorectal Cancer
Genentech, Inc. 1,953
Early research (Phase 1)Study completedNCT02457793
What this trial is testing

The Safety, Tolerability, and Effects of Cobimetinib and GDC-0994 in Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Non-Small Cell Lung Cancer, Metastatic Colorectal Cancer, Metastatic Non Small Cell Lung Cancer, Metastatic Cancers, Melanoma
Genentech, Inc. 24
Not applicableActive Not RecruitingNCT05487248
What this trial is testing

On-treatment ctDNA Changes in Chemo-refractory Colorectal Cancer Patients

Who this might be right for
Unresectable Locally Advanced Colorectal CancerMetastatic Colorectal CancerCandidate for Third-line or Subsequent Lines of Therapy
Jules Bordet Institute 103
Testing effectiveness (Phase 2)Study completedNCT00077337
What this trial is testing

FR901228 in Treating Patients With Previously Treated Unresectable Locally Advanced or Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
SWOG Cancer Research Network
Testing effectiveness (Phase 2)Looking for participantsNCT07255664
What this trial is testing

A FIH, Phase I/IIa, Trial Assessing Feasibility of Administrations of TIL-based Immunotherapy in Patients With Metastatic CRC and PC

Who this might be right for
Metastatic Colorectal CancerProstate Cancer MetastaticProstate Cancer Locally Advanced
Curacell Holding AB 12
Testing effectiveness (Phase 2)Looking for participantsNCT06051695
What this trial is testing

Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

Who this might be right for
Solid Tumor, AdultColorectal CancerNSCLC+17 more
A2 Biotherapeutics Inc. 474
Early research (Phase 1)Study completedNCT03821233
What this trial is testing

A Dose Finding Study of ZW49 in Patients With HER2-Positive Cancers

Who this might be right for
HER2-expressing Cancers
Zymeworks BC Inc. 112
Early research (Phase 1)Study completedNCT05954871
What this trial is testing

Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer

Who this might be right for
Colorectal CancerNon-Small Cell Lung Cancer
Genentech, Inc. 10
Testing effectiveness (Phase 2)Ended earlyNCT05091528
What this trial is testing

A Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive Cancers

Who this might be right for
HER2-positive Breast CancerHER2-positive Gastric CancerHER2-positive Colorectal Cancer+1 more
Silverback Therapeutics 2
Testing effectiveness (Phase 2)Active Not RecruitingNCT04117945
What this trial is testing

Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer

Who this might be right for
BRAF V600E NegativeKRAS Gene Mutation NegativeLocally Advanced Unresectable Colorectal Adenocarcinoma+10 more
Academic and Community Cancer Research United 22
Early research (Phase 1)Study completedNCT01436656
What this trial is testing

A Phase I Study of Oral LGX818 in Adult Patients With Advanced or Metastatic BRAF Mutant Melanoma

Who this might be right for
Melanoma and Metastatic Colorectal Cancer
Pfizer 107
Early research (Phase 1)Study completedNCT00648102
What this trial is testing

Phase I Study of CDX-1307, hCG-B Vaccine, for Patients With Incurable, Locally Advanced or Metastatic Breast, Colorectal, Pancreatic, Bladder or Ovarian Cancer

Who this might be right for
Breast CancerColorectal CancerPancreatic Cancer+2 more
Celldex Therapeutics 36
Testing effectiveness (Phase 2)Active Not RecruitingNCT05736731
What this trial is testing

Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression

Who this might be right for
Solid Tumor, AdultSolid TumorPancreatic Cancer+13 more
A2 Biotherapeutics Inc. 160
Early research (Phase 1)Looking for participantsNCT06440005
What this trial is testing

Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Who this might be right for
CancerAdvanced CancerLocally Advanced Carcinoma+8 more
Angiex, Inc. 80
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07260058
What this trial is testing

Immune Cell Therapy for Advanced Solid Tumors

Who this might be right for
Lung Cancer (Locally Advanced or Metastatic)Liver Cancer (Locally Advanced or Metastatic)Colorectal Cancer (Locally Advanced or Metastatic)+2 more
Liaoning Medical Diagnosis and Treatment Technology Research and Development Co., Ltd. 48
Early research (Phase 1)Ended earlyNCT05631574
What this trial is testing

Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer

Who this might be right for
Non Small Cell Lung CancerPancreatic CancerColorectal Cancer+14 more
Biomea Fusion Inc. 13
Testing effectiveness (Phase 2)Ended earlyNCT03422679
What this trial is testing

Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies

Who this might be right for
Breast CancerColorectal CancerAdenoid Cystic Carcinoma+5 more
Cellestia Biotech AG 79
Early research (Phase 1)Active Not RecruitingNCT03170960
What this trial is testing

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Urothelial CarcinomaRenal Cell CarcinomaNon-Small Cell Lung Cancer+11 more
Exelixis 914
Testing effectiveness (Phase 2)Ended earlyNCT00681876
What this trial is testing

Phase II Study of Avastin + Erbitux + Irinotecan as 2nd Line Treatment of Colorectal Cancer

Who this might be right for
Colorectal Cancer
Hellenic Oncology Research Group 16
Testing effectiveness (Phase 2)Study completedNCT01892527
What this trial is testing

Study of Tivantinib (ARQ 197) Plus Cetuximab in EGFR Inhibitor-Resistant MET High Subjects

Who this might be right for
Colorectal Cancer MetastaticC-met Overexpression
Armando Santoro, MD 43
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