Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Locally Advanced or Metastatic Malignant Solid Tumors”

63 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 63 results

Testing effectiveness (Phase 2)Looking for participantsNCT04585750
What this trial is testing

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Who this might be right for
Advanced Solid TumorAdvanced Malignant NeoplasmMetastatic Cancer+27 more
PMV Pharmaceuticals, Inc 300
Testing effectiveness (Phase 2)Looking for participantsNCT05991583
What this trial is testing

A Clinical Trial to Evaluate Effect of IBB0979 in Patients With Advanced Malignant Tumors

Who this might be right for
Advanced Malignant Tumors
SUNHO(China)BioPharmaceutical CO., Ltd. 25
Early research (Phase 1)Active Not RecruitingNCT03845166
What this trial is testing

XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

Who this might be right for
Neoplasm MalignantRenal Cell CarcinomaHormone Receptor Positive Breast Carcinoma+2 more
Exelixis 325
Testing effectiveness (Phase 2)Ended earlyNCT05326035
What this trial is testing

WJ05129 in Advanced Malignant Solid Tumors

Who this might be right for
Locally Advanced or Metastatic Malignant Solid Tumors
Suzhou Junjing BioSciences Co., Ltd. 26
Early research (Phase 1)Ended earlyNCT03295942
What this trial is testing

OMP-336B11 in Subjects With Locally Advanced or Metastatic Tumors

Who this might be right for
Locally Advanced Malignant NeoplasmMetastatic Cancer
OncoMed Pharmaceuticals, Inc. 24
Testing effectiveness (Phase 2)Looking for participantsNCT06292208
What this trial is testing

A Clinical Trial to Evaluate Effect of IBD0333 in Patients With Advanced Malignant Tumors

Who this might be right for
MTD
SUNHO(China)BioPharmaceutical CO., Ltd. 48
Early research (Phase 1)Study completedNCT04200963
What this trial is testing

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Who this might be right for
Urothelial CarcinomaUrothelial Carcinoma BladderBladder Cancer+18 more
Ikena Oncology 78
Testing effectiveness (Phase 2)Looking for participantsNCT06265025
What this trial is testing

GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors

Who this might be right for
Head and Neck CancerMalignant MelanomaColorectal Cancer+3 more
GeneMedicine Co., Ltd. 125
Testing effectiveness (Phase 2)Looking for participantsNCT07105215
What this trial is testing

A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC278 in the Treatment of Solid Tumors

Who this might be right for
Solid Tumors
RemeGen Co., Ltd. 312
Early research (Phase 1)Active Not RecruitingNCT02453620
What this trial is testing

Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer

Who this might be right for
Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Breast Adenocarcinoma+2 more
National Cancer Institute (NCI) 57
Early research (Phase 1)Study completedNCT01325558
What this trial is testing

ALT-836 in Combination With Gemcitabine for Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Locally Advanced Malignant NeoplasmMalignant Solid Tumour
Altor BioScience 30
Testing effectiveness (Phase 2)Looking for participantsNCT03682289
What this trial is testing

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors

Who this might be right for
Clear Cell Renal Cell CarcinomaLocally Advanced Pancreatic CancerLocally Advanced Malignant Solid Neoplasm+10 more
Rahul Aggarwal 89
Testing effectiveness (Phase 2)UnknownNCT05869240
What this trial is testing

BPB-101 in Subjects With Metastatic or Locally Advanced Solid Tumors

Who this might be right for
Solid Tumor
Betta Pharmaceuticals Co., Ltd. 388
Early research (Phase 1)Looking for participantsNCT04511039
What this trial is testing

Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

Who this might be right for
Advanced Malignant Solid NeoplasmClinical Stage III Gastroesophageal Junction AdenocarcinomaClinical Stage IV Gastroesophageal Junction Adenocarcinoma+26 more
Roswell Park Cancer Institute 45
Early research (Phase 1)Looking for participantsNCT06418061
What this trial is testing

Study of IBI3005 in Subjects With Unresectable, Locally Advanced or Metastatic Solid Tumors

Who this might be right for
UnresectableLocally Advanced or Metastatic Solid Tumors
Innovent Biologics (Suzhou) Co. Ltd. 198
Early research (Phase 1)Ended earlyNCT04958434
What this trial is testing

Study of TST005 in Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Locally Advanced or Metastatic CancersMetastatic Human Papillomavirus-Related Malignant Neoplasm
Suzhou Transcenta Therapeutics Co., Ltd. 19
Testing effectiveness (Phase 2)Looking for participantsNCT06016062
What this trial is testing

RC148 As a Single Agent and Combination Therapy in Patients with Locally Advanced Unresectable or Metastatic Malignant Solid Tumors

Who this might be right for
Solid Tumor
RemeGen Co., Ltd. 221
Early research (Phase 1)Study completedNCT01358903
What this trial is testing

RO5429083 in Patients With Metastatic and/or Locally Advanced, CD44-Expressing, Malignant Solid Tumors

Who this might be right for
Neoplasms
Hoffmann-La Roche 65
Early research (Phase 1)Active Not RecruitingNCT05311397
What this trial is testing

A166 in Patients With Advanced Solid Malignant Tumors

Who this might be right for
Breast Cancer
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 120
Testing effectiveness (Phase 2)Looking for participantsNCT04879121
What this trial is testing

Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Locally Advanced Malignant Solid NeoplasmMetastatic Malignant Solid Neoplasm
M.D. Anderson Cancer Center 13
Load More Results