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Results for “MGMT-Unmethylated Glioblastoma”

47 trials

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Showing 20 of 47 results

Early research (Phase 1)Active Not RecruitingNCT04555577
What this trial is testing

Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent Glioblastoma

Who this might be right for
GlioblastomaGliosarcoma
M.D. Anderson Cancer Center 29
Early research (Phase 1)Looking for participantsNCT06186401
What this trial is testing

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

Who this might be right for
EGFR Gene MutationGlioblastomaMGMT-Unmethylated Glioblastoma+1 more
Hideho Okada, MD, PhD 20
Testing effectiveness (Phase 2)Ended earlyNCT06359379
What this trial is testing

Ropidoxuridine as a Radiosensitizer in Newly Diagnosed IDH-Wildtype Glioblastoma With Unmethylated MGMT Promoter

Who this might be right for
Glioblastoma, IDH-wildtype
Shuttle Pharmaceuticals, Inc. 30
Large-scale testing (Phase 3)Study completedNCT02617589
What this trial is testing

An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)

Who this might be right for
Brain Cancer
Bristol-Myers Squibb 560
Early research (Phase 1)Ended earlyNCT03107780
What this trial is testing

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Who this might be right for
GlioblastomaGliosarcomaMGMT-Unmethylated Glioblastoma+1 more
National Cancer Institute (NCI) 32
Early research (Phase 1)Study completedNCT05938387
What this trial is testing

Safety and Tolerability of CVGBM in Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma or Astrocytoma

Who this might be right for
Glioblastoma
CureVac 37
Testing effectiveness (Phase 2)Active Not RecruitingNCT05986851
What this trial is testing

Azeliragon in MGMT Unmethylated Glioblastoma

Who this might be right for
Glioblastoma
Cantex Pharmaceuticals 30
Early research (Phase 1)Study completedNCT03452930
What this trial is testing

Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma

Who this might be right for
GlioblastomaGliosarcomaMGMT-Unmethylated Glioblastoma
M.D. Anderson Cancer Center 5
Very early researchNot Yet RecruitingNCT07778602
What this trial is testing

Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade Gliomas

Who this might be right for
MGMT-unmethylated Glioblastoma (GBM)IDH Wildtype Glioblastoma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 22
Testing effectiveness (Phase 2)Study completedNCT00813943
What this trial is testing

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status

Who this might be right for
Glioblastoma
EMD Serono 265
Early research (Phase 1)Not Yet RecruitingNCT07739017
What this trial is testing

OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma

Who this might be right for
Recurrent GlioblastomaNewly Diagnosed MGMT Unmethylated Glioblastoma
Olivia Newton-John Cancer Research Institute 54
Testing effectiveness (Phase 2)UnknownNCT04725214
What this trial is testing

Anlotinib Combined With STUPP for MGMT Nonmethylated Glioblastoma

Who this might be right for
MGMT-Unmethylated Glioblastoma
Second Affiliated Hospital, Zhejiang University, School of Medicine 33
Testing effectiveness (Phase 2)UnknownNCT06186440
What this trial is testing

Cisplatin Plus Temozolomide Compared With Temozolomide in Patients With MGMT Promotor Unmethylated Glioblastoma

Who this might be right for
Glioblastoma Multiforme of Brain
Zhongnan Hospital 60
Testing effectiveness (Phase 2)UnknownNCT05694416
What this trial is testing

Etoposide Plus Cisplatin Compared With Temozolomide in Patients With Glioblastoma

Who this might be right for
MGMT-Unmethylated Glioblastoma
Zhongnan Hospital 60
Early research (Phase 1)Active Not RecruitingNCT06973096
What this trial is testing

CART-EGFR-IL13Ra2 in Newly Diagnosed GBM Following Initial Radiotherapy

Who this might be right for
Glioblastoma
University of Pennsylvania 9
Testing effectiveness (Phase 2)Looking for participantsNCT06991101
What this trial is testing

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Who this might be right for
GlioblastomaBrain CancerGlioblastoma Multiforme+4 more
Baptist Health South Florida 190
Testing effectiveness (Phase 2)Looking for participantsNCT07326566
What this trial is testing

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Who this might be right for
Glioblastoma (GBM)Newly Diagnosed GlioblastomaGBM+4 more
Black Diamond Therapeutics, Inc. 162
Testing effectiveness (Phase 2)Looking for participantsNCT07185880
What this trial is testing

The Safety and Tolerability of MT-125 in GBM Patients

Who this might be right for
Glioblastoma (GBM)
Myosin Therapeutics Inc. 36
Testing effectiveness (Phase 2)UnknownNCT05033587
What this trial is testing

Study of AK105 With Anlotinib and Radiotherapy Adjuvant Therapy in MGMT Unmethylated Newly Diagnosed Glioblastoma.

Who this might be right for
MGMT-Unmethylated Glioblastoma
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 28
Testing effectiveness (Phase 2)Looking for participantsNCT05909618
What this trial is testing

Crizanlizumab Alone or in Combination With Nivolumab for Glioblastoma and Melanoma With Brain Metastases

Who this might be right for
Advanced GlioblastomaMetastatic Melanoma in the Central Nervous SystemMGMT-Unmethylated Glioblastoma
Sheba Medical Center 33
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