Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “MGMT-Unmethylated Glioblastoma”

45 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 45 results

Testing effectiveness (Phase 2)UnknownNCT04725214
What this trial is testing

Anlotinib Combined With STUPP for MGMT Nonmethylated Glioblastoma

Who this might be right for
MGMT-Unmethylated Glioblastoma
Second Affiliated Hospital, School of Medicine, Zhejiang University 33
Testing effectiveness (Phase 2)Active Not RecruitingNCT04121455
What this trial is testing

Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients

Who this might be right for
Glioblastoma
TME Pharma AG 117
Large-scale testing (Phase 3)Looking for participantsNCT03970447
What this trial is testing

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Who this might be right for
Glioblastoma
Global Coalition for Adaptive Research 2,250
Testing effectiveness (Phase 2)Study completedNCT03522298
What this trial is testing

Safety, Pharmacokinetics and Efficacy of Paxalisib (GDC-0084) in Newly-diagnosed Glioblastoma

Who this might be right for
Glioblastoma, Adult
Kazia Therapeutics Limited 30
Testing effectiveness (Phase 2)Looking for participantsNCT07326566
What this trial is testing

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Who this might be right for
Glioblastoma (GBM)Newly Diagnosed GlioblastomaGBM+4 more
Black Diamond Therapeutics, Inc. 162
Testing effectiveness (Phase 2)Looking for participantsNCT06504381
What this trial is testing

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

Who this might be right for
High Grade GliomaMGMT-Unmethylated GlioblastomaMGMT-Methylated Glioblastoma
University of California, San Francisco 70
Testing effectiveness (Phase 2)Active Not RecruitingNCT03866109
What this trial is testing

A Study Evaluating Temferon in Patients With Glioblastoma & Unmethylated MGMT

Who this might be right for
Glioblastoma Multiforme
Genenta Science 27
Testing effectiveness (Phase 2)UnknownNCT06186440
What this trial is testing

Cisplatin Plus Temozolomide Compared With Temozolomide in Patients With MGMT Promotor Unmethylated Glioblastoma

Who this might be right for
Glioblastoma Multiforme of Brain
Zhongnan Hospital 60
Testing effectiveness (Phase 2)UnknownNCT05033587
What this trial is testing

Study of AK105 With Anlotinib and Radiotherapy Adjuvant Therapy in MGMT Unmethylated Newly Diagnosed Glioblastoma.

Who this might be right for
MGMT-Unmethylated Glioblastoma
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 28
Testing effectiveness (Phase 2)UnknownNCT02928575
What this trial is testing

Combining Sunitinib, Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma

Who this might be right for
Glioblastoma Multiforme
Bassam Abdulkarim 45
Testing effectiveness (Phase 2)Study completedNCT03367715
What this trial is testing

Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma

Who this might be right for
MGMT-unmethylated Glioblastoma (GBM)GBM
NYU Langone Health 10
Early research (Phase 1)Ended earlyNCT03107780
What this trial is testing

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Who this might be right for
GlioblastomaGliosarcomaMGMT-Unmethylated Glioblastoma+1 more
National Cancer Institute (NCI) 32
Testing effectiveness (Phase 2)Looking for participantsNCT05879250
What this trial is testing

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma, IDH-WildtypeMGMT-Unmethylated Glioblastoma
Northwestern University 39
Early research (Phase 1)Active Not RecruitingNCT05236036
What this trial is testing

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

Who this might be right for
AstrocytomaGlioblastomaGlioblastoma, IDH-Wildtype+2 more
Northwestern University 60
Early research (Phase 1)Active Not RecruitingNCT05743595
What this trial is testing

Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

Who this might be right for
Unmethylated Glioblastoma
Washington University School of Medicine 27
Large-scale testing (Phase 3)Looking for participantsNCT06388733
What this trial is testing

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Who this might be right for
GlioblastomaGBMBrain Neoplasms, Adult, Malignant+1 more
Ivy Brain Tumor Center 450
Testing effectiveness (Phase 2)UnknownNCT03643549
What this trial is testing

Bortezomib and Temozolomide in Recurrent Grade-4 Glioma Unmethylated MGMT Promoter (BORTEM-17)

Who this might be right for
Glioblastoma
Haukeland University Hospital 63
Large-scale testing (Phase 3)Not Yet RecruitingNCT07452458
What this trial is testing

Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma

Who this might be right for
Glioblastoma, IDH-WildtypeMGMT-Unmethylated Glioblastoma
NRG Oncology 398
Testing effectiveness (Phase 2)Study completedNCT02717962
What this trial is testing

Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting

Who this might be right for
GliomaGlioblastomaGlioblastoma Multiforme+2 more
Kintara Therapeutics, Inc. 118
Early research (Phase 1)Looking for participantsNCT07343986
What this trial is testing

Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma

Who this might be right for
Glioblastoma (GBM)
University of Virginia 12
Load More Results