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Results for “MMR Mutation”

24 trials

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Showing 20 of 24 results

Testing effectiveness (Phase 2)UnknownNCT02885766
What this trial is testing

Study to Evaluate Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy of PF-114 for Oral Administration in Adults With Ph+ Chronic Myeloid Leukemia, Which is Resistant to the 2-nd Generation Bcr-Abl Inhibitors or Has T315I Mutation in the BCR-ABL Gene

Who this might be right for
Chronic Myeloid LeukemiaLeukemia, Myelogenous, Chronic, BCR-ABL Positive
Fusion Pharma LLC 65
Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Not applicableActive Not RecruitingNCT00261456
What this trial is testing

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+1 more
Institute of Cancer Research, United Kingdom 3,500
Not applicableLooking for participantsNCT07472686
What this trial is testing

Small Bowel Capsule Endoscopy in Lynch Syndrome

Who this might be right for
MMR MutationSmall Bowel AdenomaSmall-bowel Adenocarcinoma+2 more
Assistance Publique - Hôpitaux de Paris 400
Not applicableStudy completedNCT03495674
What this trial is testing

Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome

Who this might be right for
High-Frequency Microsatellite InstabilityMismatch Repair Gene MutationMutation-Negative Lynch Syndrome+1 more
M.D. Anderson Cancer Center 21
Testing effectiveness (Phase 2)Looking for participantsNCT05093231
What this trial is testing

Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
Cambridge University Hospitals NHS Foundation Trust 20
Not applicableStudy completedNCT03889171
What this trial is testing

Comparison to Psychological, Medical and Emotional Influencing Communication and Achievement Factors to Oncogenetics Tests

Who this might be right for
CancerColorectal CancerBreast Cancer+1 more
University Hospital, Montpellier 200
Not applicableUnknownNCT03757247
What this trial is testing

Prevalence of Constitutional Mismatch-repair Deficiency Among Suspected Neurofibromatosis Type 1/Legius Syndrome Children Without a Malignancy and Without a NF1 or SPRED1 Mutation

Who this might be right for
Neurofibromatosis Type 1
Medical University Innsbruck 670
Testing effectiveness (Phase 2)Active Not RecruitingNCT01885702
What this trial is testing

Dendritic Cell Vaccination in Patients With Lynch Syndrome or Colorectal Cancer With MSI

Who this might be right for
Colorectal Cancer
Radboud University Medical Center 25
Testing effectiveness (Phase 2)Active Not RecruitingNCT05384587
What this trial is testing

Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia

Who this might be right for
Chronic Myelogenous Leukemia - Chronic Phase
Novartis Pharmaceuticals 34
Very early researchLooking for participantsNCT06305962
What this trial is testing

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

Who this might be right for
PDL1 Gene MutationNon Small Cell Lung CancerSmall Cell Lung Cancer ( SCLC )+6 more
Radiopharm Theranostics, Ltd 30
Not applicableUnknownNCT04516083
What this trial is testing

Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation

Who this might be right for
Cancer Gene MutationLynch SyndromeEndometrial Cancer+1 more
RWJ Barnabas Health at Jersey City Medical Center 100
Early research (Phase 1)Ended earlyNCT06625515
What this trial is testing

First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers

Who this might be right for
Advanced Solid TumorsBreast Cancer RecurrentColorectal Cancer Metastatic+3 more
Accent Therapeutics 17
Testing effectiveness (Phase 2)Looking for participantsNCT05197322
What this trial is testing

NEOadjuvant PembRolizumab In Stratified Medicine - ColoRectal Cancer

Who this might be right for
Adenocarcinoma of the Colon
University College, London 88
Not applicableLooking for participantsNCT05129605
What this trial is testing

Prostate Cancer Genetic Risk Evaluation and Screening Study

Who this might be right for
Prostatic NeoplasmProstate CancerBRCA2 Mutation+5 more
Massachusetts General Hospital 400
Not applicableLooking for participantsNCT05097274
What this trial is testing

The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+4 more
Institute of Cancer Research, United Kingdom 50
Early research (Phase 1)Looking for participantsNCT05787587
What this trial is testing

PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic Solid TumorsBreast CancerOvarian Cancer+6 more
IDEAYA Biosciences 216
Large-scale testing (Phase 3)Study completedNCT04666259
What this trial is testing

Asciminib in Monotherapy for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation

Who this might be right for
Chronic Myelogenous Leukemia - Chronic Phase
Novartis Pharmaceuticals 56
Not applicableLooking for participantsNCT07450612
What this trial is testing

Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection

Who this might be right for
Colorectal CancerAdenoma ColonAdenoma Colon Polyp+16 more
San Raffaele University 1,200
Not applicableLooking for participantsNCT06708429
What this trial is testing

Lynch Syndrome X-Talk of Enteral Mucosa With Immune System

Who this might be right for
Lynch SyndromeLynch Syndrome ILynch Syndrome II+19 more
San Raffaele University 300
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