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Results for “MSI and or dMMR”

58 trials

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Showing 20 of 58 results

Large-scale testing (Phase 3)Looking for participantsNCT06346197
What this trial is testing

Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas

Who this might be right for
Gastric CancerMSI-HMetastatic Cancer+1 more
Centre Leon Berard 132
Testing effectiveness (Phase 2)Active Not RecruitingNCT06116136
What this trial is testing

Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers.

Who this might be right for
MSI-H/dMMR Gastroesophageal-junction CancerMSI-H/dMMR Gastric Cancer
Servier Bio-Innovation LLC 38
Post-approval studies (Phase 4)Not Yet RecruitingNCT06897527
What this trial is testing

Evaluate the Safety of Dostarlimab in Adult Participants in India With Recurrent or Advanced Endometrial Cancer (EC)

Who this might be right for
Neoplasms, Endometrial
GlaxoSmithKline 100
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07009145
What this trial is testing

QL1706 Plus Bevacizumab for Unresectable or Metastatic MSI-H/dMMR CRC

Who this might be right for
Unresectable Colorectal CancerMetastatic Colorectal Cancer (CRC)MSI-H/dMMR Colorectal Cancer
Qianfoshan Hospital 22
Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Large-scale testing (Phase 3)Looking for participantsNCT05890742
What this trial is testing

A Clinical Trial Evaluating the Efficacy and Safety of IBI310 in Combination With Sintilimab, for Neoadjuvant Treatment of MSI-H/dMMR Resectable Colon Cancer

Who this might be right for
MSI-H
Innovent Biologics (Suzhou) Co. Ltd. 360
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07262619
What this trial is testing

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Who this might be right for
Advanced Solid TumorsMSI-H or dMMR Advanced Solid TumorsMSI-H/dMMR Gastric Cancer+4 more
Eikon Therapeutics 160
Testing effectiveness (Phase 2)UnknownNCT04326829
What this trial is testing

QL1604 Monotherapy for dMMR or MSI-H Advanced Solid Tumors

Who this might be right for
Advanced Malignant Tumor
Qilu Pharmaceutical Co., Ltd. 86
Testing effectiveness (Phase 2)Study completedNCT02060188
What this trial is testing

Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread

Who this might be right for
Microsatellite Unstable Colorectal CancerMicrosatellite Stable Colorectal CancerMismatch Repair Proficient Colorectal Cancer+1 more
Bristol-Myers Squibb 385
Testing effectiveness (Phase 2)Looking for participantsNCT06580574
What this trial is testing

Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers

Who this might be right for
Gastric CancerColon CancerMSI-H+1 more
Peking University 38
Testing effectiveness (Phase 2)Active Not RecruitingNCT04730544
What this trial is testing

Two Combination Treatment Regimens of Nivolumab and Ipilimumab in Patients With dMMR and / or MSI mCRC.

Who this might be right for
Colorectal Cancer MetastaticMSI-H Colorectal Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group 96
Testing effectiveness (Phase 2)Active Not RecruitingNCT05836584
What this trial is testing

Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer

Who this might be right for
Clinical Stage I Gastric Cancer AJCC v8Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage II Gastric Cancer AJCC v8+7 more
National Cancer Institute (NCI) 240
Testing effectiveness (Phase 2)Active Not RecruitingNCT05118724
What this trial is testing

Atezolizumab in Patients With MSI-h/MMR-D Stage II High Risk and Stage III Colorectal Cancer Ineligible for Oxaliplatin

Who this might be right for
Colorectal Cancer
AIO-Studien-gGmbH 80
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07151209
What this trial is testing

Immunotherapy Combined With Anti-angiogenic Therapy and Chemotherapy for Potentially Resectable MSI-H, dMMR Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

Who this might be right for
Gastric or Gastroesophageal Junction Adenocarcinoma
The First Affiliated Hospital with Nanjing Medical University 20
Testing effectiveness (Phase 2)Looking for participantsNCT06047379
What this trial is testing

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Who this might be right for
Diffuse Astrocytoma, IDH-MutantGlioblastoma, IDH-wildtypeBrain Metastases, Adult+18 more
Neonc Technologies, Inc. 134
Testing effectiveness (Phase 2)Looking for participantsNCT03736889
What this trial is testing

Tislelizumab (Anti-Programmed Cell Death Protein-1 (PD-1) Antibody) in MSI-H or dMMR Solid Tumors

Who this might be right for
MSI-H/dMMR Solid Tumors
BeiGene 200
Early research (Phase 1)Study completedNCT03894618
What this trial is testing

SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas

Who this might be right for
Squamous Cell Carcinoma of the Head and NeckMelanomaNon Small Cell Lung Cancer+10 more
Shattuck Labs, Inc. 49
Testing effectiveness (Phase 2)UnknownNCT04988191
What this trial is testing

Toripalimab Plus Bevacizumab and Chemotherapy as Neoadjuvant Therapy in Advanced MSI-H or dMMR Colorectal Cancer

Who this might be right for
Colorectal Carcinoma
Peking University 44
Early research (Phase 1)Study completedNCT03053466
What this trial is testing

APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

Who this might be right for
Solid TumorMicrosatellite InstabilityMismatch Repair Deficiency+1 more
Apollomics (Australia) Pty. Ltd. 30
Large-scale testing (Phase 3)Looking for participantsNCT05770102
What this trial is testing

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition

Who this might be right for
MalignancyMalignant NeoplasmLymphoproliferative Disorders+7 more
Cancer Research UK 30
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