Testing effectiveness (Phase 2)Looking for participantsNCT03667170What this trial is testingKN035 for dMMR/MSI-H Advanced Solid TumorsWho this might be right forSolid Tumor 3D Medicines (Sichuan) Co., Ltd. 200
Early research (Phase 1)Study completedNCT04242199What this trial is testingSafety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid TumorsWho this might be right forAdvanced Solid TumorMSI-H/dMMR TumorsCutaneous Squamous Cell Carcinoma+9 more Incyte Corporation 182
Testing effectiveness (Phase 2)WithdrawnNCT04001101What this trial is testingAnti-PD-1 +/- RT for MSI-H Solid TumorsWho this might be right forMicrosatellite Instability HighMismatch Repair DeficiencyColorectal Cancer University of Colorado, Denver
Early research (Phase 1)Ended earlyNCT05909995What this trial is testingInterventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid TumorsWho this might be right forMelanomaHepatocellular Carcinoma (HCC)Renal Cell Carcinoma (RCC)+3 more Incyte Corporation 8
Testing effectiveness (Phase 2)Active Not RecruitingNCT05879822What this trial is testingEvaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor NaiveWho this might be right forAdvanced Solid Tumor Incyte Corporation 73
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07259473What this trial is testingFactors Influencing Immunotherapy Response in dMMR/MSI-H Gastric/Gastroesophageal Junction AdenocarcinomaWho this might be right forGastric / Gastroesophageal Junction AdenocarcinomaMismatch Repair Deficient or MSI-High Solid TumorsImmunotherapy Shanghai Zhongshan Hospital 15
Testing effectiveness (Phase 2)UnknownNCT03475953What this trial is testingA Phase I/II Study of Regorafenib Plus Avelumab in Solid TumorsWho this might be right forColorectal Cancer Not MSI-H or MMR-deficientGISTOesophageal or Gastric Carcinoma+12 more Institut Bergonié 747
Early research (Phase 1)Ended earlyNCT04272034What this trial is testingSafety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid TumorsWho this might be right forAdvanced Solid TumorsMSI-H/dMMR TumorsCutaneous Squamous Cell Carcinoma+15 more Incyte Corporation 105
Not applicableUnknownNCT06004713What this trial is testingRegistry Study in MSI/dMMR Solid TumorsWho this might be right forDMMR CancerMSI-HSolid Tumor Peking University Cancer Hospital & Institute 190
Early research (Phase 1)Ended earlyNCT04458259What this trial is testingStudy of PF-07265807 in Participants With Metastatic Solid Tumors.Who this might be right forNeoplasm Metastasis Pfizer 88
Early research (Phase 1)Looking for participantsNCT06974110What this trial is testingStudy of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid TumorsWho this might be right forAdvanced Solid TumorMetastatic Solid TumorEndometrial Cancer+4 more MOMA Therapeutics 132
Early research (Phase 1)Study completedNCT03236935What this trial is testingPhase Ib of L-NMMA and PembrolizumabWho this might be right forNon-Small Cell Lung CancerMalignant MelanomaHead and Neck Squamous Cell Carcinoma+3 more The Methodist Hospital Research Institute 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT05200559What this trial is testingT-regulatory Cell Depletion With E7777 Combined With Pembrolizumab in Recurrent or Metastatic Solid TumorsWho this might be right forEpithelial Ovarian Cancer Alexander B Olawaiye, MD 25
Testing effectiveness (Phase 2)Looking for participantsNCT03941574What this trial is testingA Clinical Study to Evaluate HLX10 Monotherapy for the Treatment of MSI-H or dMMR Solid Tumors That Failed to Respond to Standard TherapyWho this might be right forMSI-H Solid Malignant Tumor Shanghai Henlius Biotech 108
Testing effectiveness (Phase 2)Ended earlyNCT04547101What this trial is testingAK104 in Subjects With Locally Advanced Unresectable or Metastatic MSI-H/dMMR Solid TumorsWho this might be right forMSI-H/dMMR Solid Tumor Akeso 6
Testing effectiveness (Phase 2)Looking for participantsNCT07003022What this trial is testingPhase Ⅱ Clinical Trial of Cadonilimab Combined With Anti-angiogenic Agents in Metastatic dMMR/MSI-H CRCWho this might be right forColo-rectal CancerMSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers Fudan University 40
Large-scale testing (Phase 3)Looking for participantsNCT05770102What this trial is testingDETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) DispositionWho this might be right forMalignancyMalignant NeoplasmLymphoproliferative Disorders+7 more Cancer Research UK 30
Early research (Phase 1)Looking for participantsNCT07403721What this trial is testingAMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid TumorsWho this might be right forMetastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR) Amgen 464
Testing effectiveness (Phase 2)Looking for participantsNCT07213609What this trial is testingInvestigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid TumorsWho this might be right forNeoplasms, ColorectalNeoplasms GlaxoSmithKline 47
Testing effectiveness (Phase 2)UnknownNCT03544723What this trial is testingSafety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.Who this might be right forSolid TumorLymphoma MultiVir, Inc. 40