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Results for “MSI-H Solid Malignant Tumor”

48 trials

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Showing 20 of 48 results

Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Testing effectiveness (Phase 2)Active Not RecruitingNCT05199272
What this trial is testing

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

Who this might be right for
Solid TumorClear Cell Renal Cell CarcinomaEpithelial Ovarian Cancer+6 more
23andMe, Inc. 141
Testing effectiveness (Phase 2)Active Not RecruitingNCT03228667
What this trial is testing

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

Who this might be right for
Non-Small Cell Lung CancerSmall Cell Lung CancerUrothelial Carcinoma+10 more
ImmunityBio, Inc. 40
Testing effectiveness (Phase 2)Study completedNCT03436563
What this trial is testing

M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

Who this might be right for
Colon AdenocarcinomaHigh-Frequency Microsatellite InstabilityMetastatic Malignant Solid Neoplasm+8 more
M.D. Anderson Cancer Center 4
Testing effectiveness (Phase 2)Active Not RecruitingNCT05879822
What this trial is testing

Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive

Who this might be right for
Advanced Solid Tumor
Incyte Corporation 73
Early research (Phase 1)Looking for participantsNCT04777994
What this trial is testing

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

Who this might be right for
Advanced Solid Tumor Cancer
Calico Life Sciences LLC 248
Testing effectiveness (Phase 2)Active Not RecruitingNCT06710847
What this trial is testing

Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

Who this might be right for
Neoplasms, ColorectalSolid TumorColon Cancer+2 more
GlaxoSmithKline 14
Not applicableNot Yet RecruitingNCT07374809
What this trial is testing

IMMUNOTHERAPY EFFICACY TARGETING ENDOMETRIAL CANCER

Who this might be right for
Endometrial Carcinoma (EC)pMMRDMMR Cancer
European Institute of Oncology 50
Testing effectiveness (Phase 2)Looking for participantsNCT03667170
What this trial is testing

KN035 for dMMR/MSI-H Advanced Solid Tumors

Who this might be right for
Solid Tumor
3D Medicines (Sichuan) Co., Ltd. 200
Testing effectiveness (Phase 2)Looking for participantsNCT05483400
What this trial is testing

Open Label Phase 2 Basket Trial With Atezolizumab and Tiragolumab in Solid Tumors

Who this might be right for
Head and Neck NeoplasmsMSI-H CancerMelanoma
University Medical Center Groningen 97
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06873854
What this trial is testing

LM-108 in Combination With Toripalimab in Subjects With Advanced Solid Tumours

Who this might be right for
Advanced Solid Tumor
LaNova Medicines Limited 84
Testing effectiveness (Phase 2)WithdrawnNCT04001101
What this trial is testing

Anti-PD-1 +/- RT for MSI-H Solid Tumors

Who this might be right for
Microsatellite Instability HighMismatch Repair DeficiencyColorectal Cancer
University of Colorado, Denver
Testing effectiveness (Phase 2)Looking for participantsNCT06580574
What this trial is testing

Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers

Who this might be right for
Gastric CancerColon CancerMSI-H+1 more
Peking University 38
Testing effectiveness (Phase 2)Looking for participantsNCT04114136
What this trial is testing

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Who this might be right for
MelanomaNSCLCHepatocellular Carcinoma+5 more
Dan Zandberg 72
Testing effectiveness (Phase 2)UnknownNCT04521075
What this trial is testing

A Phase Ib Trial to Evaluate the Safety and Efficacy of FMT and Nivolumab in Subjects With Metastatic or Inoperable Melanoma, MSI-H, dMMR or NSCLC

Who this might be right for
Melanoma Stage IVUnresectable MelanomaNSCLC Stage IV
Ella Therapeutics Ltd 42
Testing effectiveness (Phase 2)Active Not RecruitingNCT04969887
What this trial is testing

Combination Immunotherapy in Rare Cancers Under InvesTigation

Who this might be right for
Advanced Biliary Tract CancerNeuroendocrine TumorsFemale Reproductive System Neoplasm+1 more
Olivia Newton-John Cancer Research Institute 240
Testing effectiveness (Phase 2)UnknownNCT04291248
What this trial is testing

Anlotinib Combined With AK105 Injection in Subjects With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Advanced Solid Tumor

Who this might be right for
MSI-H or dMMR Advanced Solid Tumors
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 138
Testing effectiveness (Phase 2)Ended earlyNCT04800627
What this trial is testing

Pevonedistat and Pembrolizumab for the Treatment of dMMR/MSI-H Metastatic or Locally Advanced Unresectable Solid Tumor

Who this might be right for
Locally Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
M.D. Anderson Cancer Center 2
Early research (Phase 1)Study completedNCT04242199
What this trial is testing

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorMSI-H/dMMR TumorsCutaneous Squamous Cell Carcinoma+9 more
Incyte Corporation 182
Testing effectiveness (Phase 2)UnknownNCT03810339
What this trial is testing

Toripalimab as Monotherapy in Participants With POLE or POLD-1 Mutated and Non-MSI-H Advanced Solid Tumors

Who this might be right for
Solid TumorAdvanced Cancer
Sun Yat-sen University 35
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