Testing effectiveness (Phase 2)Looking for participantsNCT03667170What this trial is testingKN035 for dMMR/MSI-H Advanced Solid TumorsWho this might be right forSolid Tumor 3D Medicines (Sichuan) Co., Ltd. 200
Testing effectiveness (Phase 2)UnknownNCT03475953What this trial is testingA Phase I/II Study of Regorafenib Plus Avelumab in Solid TumorsWho this might be right forColorectal Cancer Not MSI-H or MMR-deficientGISTOesophageal or Gastric Carcinoma+12 more Institut Bergonié 747
Early research (Phase 1)Ended earlyNCT04272034What this trial is testingSafety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid TumorsWho this might be right forAdvanced Solid TumorsMSI-H/dMMR TumorsCutaneous Squamous Cell Carcinoma+15 more Incyte Corporation 105
Early research (Phase 1)Ended earlyNCT04458259What this trial is testingStudy of PF-07265807 in Participants With Metastatic Solid Tumors.Who this might be right forNeoplasm Metastasis Pfizer 88
Early research (Phase 1)Looking for participantsNCT06974110What this trial is testingStudy of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid TumorsWho this might be right forAdvanced Solid TumorMetastatic Solid TumorEndometrial Cancer+4 more MOMA Therapeutics 132
Testing effectiveness (Phase 2)Ended earlyNCT04547101What this trial is testingAK104 in Subjects With Locally Advanced Unresectable or Metastatic MSI-H/dMMR Solid TumorsWho this might be right forMSI-H/dMMR Solid Tumor Akeso 6
Testing effectiveness (Phase 2)Looking for participantsNCT07003022What this trial is testingPhase Ⅱ Clinical Trial of Cadonilimab Combined With Anti-angiogenic Agents in Metastatic dMMR/MSI-H CRCWho this might be right forColo-rectal CancerMSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers Fudan University 40
Early research (Phase 1)Looking for participantsNCT07403721What this trial is testingAMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid TumorsWho this might be right forMetastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR) Amgen 464
Early research (Phase 1)Not Yet RecruitingNCT07552376What this trial is testingThis Study Aims to Evaluate the Efficacy and Safety of QLS1317 in Patients With MSI-H/dMMR Advanced Solid Tumors.Who this might be right forMSI-H or dMMR Advanced Solid Tumors Shanghai Qilu Pharmaceutical Research and Development Center LTD 120
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07266025What this trial is testingAdebrelimab Combined With Induction Chemotherapy or SHR-8068 for Mismatch Repair-Deficient/Microsatellite Instability-High (dMMR/MSI-H) Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma：A Randomized, Non-comparative Phase 2 StudyWho this might be right forGastric AdenocarcinomaGastroesophageal AdenocarcinomaMismatch Repair Deficient or MSI-High Solid Tumors+1 more Shanghai Zhongshan Hospital 30
Testing effectiveness (Phase 2)Looking for participantsNCT03736889What this trial is testingTislelizumab (Anti-Programmed Cell Death Protein-1 (PD-1) Antibody) in MSI-H or dMMR Solid TumorsWho this might be right forMSI-H/dMMR Solid Tumors BeiGene 200
Early research (Phase 1)Study completedNCT02635672What this trial is testingPhase I Dose Escalation Study for VIP152 in Patients With Advanced CancerWho this might be right forNeoplasms Vincerx Pharma, Inc. 110
Early research (Phase 1)Active Not RecruitingNCT05838768What this trial is testingStudy of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.Who this might be right forMSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers Novartis Pharmaceuticals 123
Testing effectiveness (Phase 2)Looking for participantsNCT05086692What this trial is testingA Beta-only IL-2 ImmunoTherapY StudyWho this might be right forAdvanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more Medicenna Therapeutics, Inc. 115
Early research (Phase 1)Looking for participantsNCT07208136What this trial is testingJMKX005425 in Patients With MSI-H/dMMR Advanced Solid TumorsWho this might be right forAdvanced Solid Tumors Jemincare 102
Testing effectiveness (Phase 2)Ended earlyNCT04800627What this trial is testingPevonedistat and Pembrolizumab for the Treatment of dMMR/MSI-H Metastatic or Locally Advanced Unresectable Solid TumorWho this might be right forLocally Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm M.D. Anderson Cancer Center 2
Testing effectiveness (Phase 2)Looking for participantsNCT07262619What this trial is testingEIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) TumorsWho this might be right forAdvanced Solid TumorsMSI-H or dMMR Advanced Solid TumorsMSI-H/dMMR Gastric Cancer+4 more Eikon Therapeutics 160
Testing effectiveness (Phase 2)UnknownNCT04291248What this trial is testingAnlotinib Combined With AK105 Injection in Subjects With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Advanced Solid TumorWho this might be right forMSI-H or dMMR Advanced Solid Tumors Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 138
Early research (Phase 1)Ended earlyNCT03407976What this trial is testingApatinib With Pembrolizumab in Previously Treated Advanced MalignanciesWho this might be right forAdvanced MalignanciesUrothelial CarcinomaMSI-H or dMMR Solid Tumors+1 more University of Utah 5
Testing effectiveness (Phase 2)UnknownNCT04326829What this trial is testingQL1604 Monotherapy for dMMR or MSI-H Advanced Solid TumorsWho this might be right forAdvanced Malignant Tumor Qilu Pharmaceutical Co., Ltd. 86