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Results for “MTAP Deletion”

40 trials

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Showing 20 of 40 results

Early research (Phase 1)Not Yet RecruitingNCT07567859
What this trial is testing

HS-10587 in Patients With Advanced Solid Tumors

Who this might be right for
MTAP Deletion
Jiangsu Hansoh Pharmaceutical Co., Ltd. 362
Early research (Phase 1)Looking for participantsNCT06672523
What this trial is testing

Evaluate the Mass Balance, Metabolism, Elimination, and Drug Levels of [14C]-BMS-986504 (MRTX1719) in Participants With Advanced Solid Tumors With Homozygous Methylthioadenosine Phosphorylase Deletion

Who this might be right for
Advanced Solid Tumors With Homozygous MTAP Deletion
Bristol-Myers Squibb 8
Early research (Phase 1)Ended earlyNCT06568614
What this trial is testing

An Investigational Study of BG-89894 Tablets in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic MTAP-deleted Solid Tumors
BeOne Medicines 29
Testing effectiveness (Phase 2)Looking for participantsNCT05732831
What this trial is testing

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

Who this might be right for
Locally Advanced Solid Tumor
Tango Therapeutics, Inc. 225
Testing effectiveness (Phase 2)Active Not RecruitingNCT06593522
What this trial is testing

Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)

Who this might be right for
MTAP-deleted NSCLC
Amgen 61
Early research (Phase 1)Active Not RecruitingNCT06333951
What this trial is testing

Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

Who this might be right for
Thoracic TumorsNon-small Cell Lung Cancer
Amgen 49
Testing effectiveness (Phase 2)Looking for participantsNCT06414460
What this trial is testing

Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors

Who this might be right for
Locally Advanced/Metastatic Solid Tumors
InSilico Medicine Hong Kong Limited 146
Early research (Phase 1)Looking for participantsNCT07469982
What this trial is testing

A Phase I Study of SY-9453 in Patients With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic Solid Tumors With Homozygous MTAP Deletion
Shouyao Holdings (Beijing) Co. LTD 122
Early research (Phase 1)Looking for participantsNCT06973863
What this trial is testing

PEP08 in Patients With MTAP-Del Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced Solid TumorSolid TumorsMTAP-deleted Solid Tumors+1 more
PharmaEngine 40
Early research (Phase 1)Looking for participantsNCT07601243
What this trial is testing

Study of GS-2426 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Gilead Sciences 174
Early research (Phase 1)Ended earlyNCT03435250
What this trial is testing

Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss

Who this might be right for
Advanced Solid TumorsLymphoma
Institut de Recherches Internationales Servier 123
Early research (Phase 1)Looking for participantsNCT07071090
What this trial is testing

DC50292A Tablet in Patients With MTAP-deleted Advanced or Metastatic Solid Tumors

Who this might be right for
Solid Tumor Malignancies
Heronova Pharmaceuticals 32
Early research (Phase 1)Looking for participantsNCT05245500
What this trial is testing

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Who this might be right for
MesotheliomaNon Small Cell Lung CancerMalignant Peripheral Nerve Sheath Tumors+3 more
Bristol-Myers Squibb 336
Early research (Phase 1)Looking for participantsNCT07077434
What this trial is testing

Assess Safety, Tolerability and Drug Levels of Navlimetostat (BMS-986504) in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Bristol-Myers Squibb 32
Testing effectiveness (Phase 2)Looking for participantsNCT06630416
What this trial is testing

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

Who this might be right for
Metastatic Bladder Urothelial CarcinomaMetastatic Malignant Solid NeoplasmStage IV Bladder Cancer AJCC v8+1 more
Northwestern University 64
Early research (Phase 1)Not Yet RecruitingNCT07777133
What this trial is testing

Evaluate the Metabolism, the Routes and Extent of Elimination, and Drug Levels of [14C]Navlimetostat (BMS-986504) in Healthy Female Participants

Who this might be right for
Healthy Female Participants
Bristol-Myers Squibb 6
Testing effectiveness (Phase 2)Looking for participantsNCT06922591
What this trial is testing

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

Who this might be right for
PDACPDAC - Pancreatic Ductal AdenocarcinomaNSCLC+5 more
Tango Therapeutics, Inc. 183
Testing effectiveness (Phase 2)Looking for participantsNCT07594626
What this trial is testing

BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion

Who this might be right for
Metastatic Biliary Tract CarcinomaMetastatic Colon CarcinomaMetastatic Esophageal Carcinoma+5 more
Northwestern University 72
Early research (Phase 1)Not Yet RecruitingNCT07583771
What this trial is testing

A Phase Ⅰ Study of CS08399 in Participants With MTAP-deleted Solid Tumors and Lymphoma

Who this might be right for
Pancreatic AdenocarcinomaNon Small Cell Lung CancerAdvanced Solid Tumors+2 more
Chipscreen Biosciences, Ltd. 186
Very early researchLooking for participantsNCT06883747
What this trial is testing

Clinical Trial of BMS-986504 in Recurrent GBM Patients

Who this might be right for
Glioblastoma WHO Grade IV
Nader Sanai 12
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