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Results for “MTAP Deletion”

27 trials

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Showing 20 of 27 results

Early research (Phase 1)Looking for participantsNCT06568614
What this trial is testing

An Investigational Study of BG-89894 Tablets in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic MTAP-deleted Solid Tumors
BeOne Medicines 140
Testing effectiveness (Phase 2)Looking for participantsNCT06914128
What this trial is testing

A First-in-human Study to Learn How Safe BAY 3713372 is and How it Works in Participants With MTAP-deleted Solid Tumors

Who this might be right for
MTAP-deleted Solid Tumors
Bayer 370
Large-scale testing (Phase 3)Looking for participantsNCT07076121
What this trial is testing

A Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)

Who this might be right for
Pancreatic Ductal Adenocarcinoma
Bristol-Myers Squibb 470
Very early researchLooking for participantsNCT06883747
What this trial is testing

Clinical Trial of BMS-986504 in Recurrent GBM Patients

Who this might be right for
Glioblastoma WHO Grade IV
Nader Sanai 9
Early research (Phase 1)Looking for participantsNCT07277413
What this trial is testing

IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

Who this might be right for
NSCLC AdenocarcinomaGastroesophageal Cancer (GC)Gastric Adenocarcinoma+8 more
IDEAYA Biosciences 260
Early research (Phase 1)Looking for participantsNCT06414460
What this trial is testing

Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors

Who this might be right for
Locally Advanced/Metastatic Solid Tumors
InSilico Medicine Hong Kong Limited 80
Early research (Phase 1)Looking for participantsNCT07128303
What this trial is testing

Study of GS-5319 in Adults With Solid Tumors

Who this might be right for
Advanced Solid Tumor
Gilead Sciences 178
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07283705
What this trial is testing

A Phase II Study Evaluating BMS-986504 in MTAP-deleted Pancreatic Cancer

Who this might be right for
Phase 2 StudyBMS-986504MTAP-deleted Pancreatic Cancer
M.D. Anderson Cancer Center 60
Early research (Phase 1)Looking for participantsNCT05245500
What this trial is testing

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Who this might be right for
MesotheliomaNon Small Cell Lung CancerMalignant Peripheral Nerve Sheath Tumors+3 more
Bristol-Myers Squibb 336
Early research (Phase 1)Looking for participantsNCT07071090
What this trial is testing

DC50292A Tablet in Patients With MTAP-deleted Advanced or Metastatic Solid Tumors

Who this might be right for
Solid Tumor Malignancies
Heronova Pharmaceuticals 32
Early research (Phase 1)Looking for participantsNCT06973863
What this trial is testing

PEP08 in Patients With MTAP-Del Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced Solid TumorSolid TumorsMTAP-deleted Solid Tumors+1 more
PharmaEngine 40
Testing effectiveness (Phase 2)Looking for participantsNCT06855771
What this trial is testing

BMS-986504 in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Bristol-Myers Squibb 130
Early research (Phase 1)Looking for participantsNCT07077434
What this trial is testing

Assess Safety, Tolerability and Drug Levels of BMS-986504 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Bristol-Myers Squibb 32
Early research (Phase 1)Ended earlyNCT03435250
What this trial is testing

Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss

Who this might be right for
Advanced Solid TumorsLymphoma
Institut de Recherches Internationales Servier 123
Early research (Phase 1)Looking for participantsNCT06796699
What this trial is testing

A Phase Ia/Ib Clinical Study of GH56 Capsules in Subjects With MTAP-Deleted Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors With MTAP Gene Deletion
Suzhou Genhouse Bio Co., Ltd. 90
Not applicableStudy completedNCT03361358
What this trial is testing

Pre-Screening Study to Identify MTAP Loss in Advanced Solid Tumors or Lymphoma

Who this might be right for
Advanced Solid TumorsLymphoma
Agios Pharmaceuticals, Inc. 44
Testing effectiveness (Phase 2)Looking for participantsNCT05732831
What this trial is testing

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

Who this might be right for
Locally Advanced Solid Tumor
Tango Therapeutics, Inc. 225
Early research (Phase 1)Looking for participantsNCT06672523
What this trial is testing

Evaluate the Mass Balance, Metabolism, Elimination, and Drug Levels of [14C]-BMS-986504 (MRTX1719) in Participants With Advanced Solid Tumors With Homozygous Methylthioadenosine Phosphorylase Deletion

Who this might be right for
Advanced Solid Tumors With Homozygous MTAP Deletion
Bristol-Myers Squibb 8
Early research (Phase 1)Looking for participantsNCT06333951
What this trial is testing

AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

Who this might be right for
Thoracic TumorsNon-small Cell Lung Cancer
Amgen 500
Early research (Phase 1)Looking for participantsNCT04794699
What this trial is testing

Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion

Who this might be right for
Solid Tumor
IDEAYA Biosciences 180
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