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Results for “MTAP Deletion”

38 trials

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Showing 20 of 38 results

Early research (Phase 1)Not Yet RecruitingNCT07567859
What this trial is testing

HS-10587 in Patients With Advanced Solid Tumors

Who this might be right for
MTAP Deletion
Jiangsu Hansoh Pharmaceutical Co., Ltd. 362
Testing effectiveness (Phase 2)Looking for participantsNCT06914128
What this trial is testing

PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

Who this might be right for
MTAP-deleted Solid Tumors
Bayer 450
Not applicableActive Not RecruitingNCT07593573
What this trial is testing

The Exploration of MTAP Deletion in Osteosarcoma by Immunohistochemistry

Who this might be right for
OsteosarcomaMTAP DeletionImmunohistochemistry
Peking University People's Hospital 100
Early research (Phase 1)Active Not RecruitingNCT06360354
What this trial is testing

A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)

Who this might be right for
Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers
Amgen 120
Large-scale testing (Phase 3)Looking for participantsNCT07063745
What this trial is testing

Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

Who this might be right for
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Bristol-Myers Squibb 590
Testing effectiveness (Phase 2)Active Not RecruitingNCT06593522
What this trial is testing

Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)

Who this might be right for
MTAP-deleted NSCLC
Amgen 61
Early research (Phase 1)Looking for participantsNCT07077434
What this trial is testing

Assess Safety, Tolerability and Drug Levels of Navlimetostat (BMS-986504) in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Bristol-Myers Squibb 32
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07492680
What this trial is testing

BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

Who this might be right for
Solid Tumors
Bristol-Myers Squibb 260
Testing effectiveness (Phase 2)Looking for participantsNCT06922591
What this trial is testing

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

Who this might be right for
PDACPDAC - Pancreatic Ductal AdenocarcinomaNSCLC+5 more
Tango Therapeutics, Inc. 183
Early research (Phase 1)Ended earlyNCT06568614
What this trial is testing

An Investigational Study of BG-89894 Tablets in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic MTAP-deleted Solid Tumors
BeOne Medicines 29
Early research (Phase 1)Looking for participantsNCT07532902
What this trial is testing

BMS-986504 With Standard-of-Care Therapy for People With Solid Tumor Cancer

Who this might be right for
Diffuse Pleural MesotheliomaGastroesophageal CarcinomaUrothelial Carcinoma
Memorial Sloan Kettering Cancer Center 60
Early research (Phase 1)Not Yet RecruitingNCT07601243
What this trial is testing

Study of GS-2426 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Gilead Sciences 174
Testing effectiveness (Phase 2)Active Not RecruitingNCT06188702
What this trial is testing

S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP

Who this might be right for
MTAP-deleted Solid Tumors
Servier Bio-Innovation LLC 60
Testing effectiveness (Phase 2)Looking for participantsNCT07283705
What this trial is testing

A Phase II Study Evaluating BMS-986504 in MTAP-deleted Pancreatic Cancer

Who this might be right for
Phase 2 StudyBMS-986504MTAP-deleted Pancreatic Cancer
M.D. Anderson Cancer Center 60
Early research (Phase 1)Active Not RecruitingNCT06333951
What this trial is testing

Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

Who this might be right for
Thoracic TumorsNon-small Cell Lung Cancer
Amgen 49
Early research (Phase 1)Looking for participantsNCT07128303
What this trial is testing

Study of GS-5319 in Adults With Solid Tumors

Who this might be right for
Advanced Solid Tumor
Gilead Sciences 178
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07549022
What this trial is testing

Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor

Who this might be right for
Malignant Peripheral Nerve Sheath TumorsMPNST
Ankit Mangla, MD 17
Early research (Phase 1)Looking for participantsNCT06672523
What this trial is testing

Evaluate the Mass Balance, Metabolism, Elimination, and Drug Levels of [14C]-BMS-986504 (MRTX1719) in Participants With Advanced Solid Tumors With Homozygous Methylthioadenosine Phosphorylase Deletion

Who this might be right for
Advanced Solid Tumors With Homozygous MTAP Deletion
Bristol-Myers Squibb 8
Testing effectiveness (Phase 2)Ended earlyNCT05275478
What this trial is testing

Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

Who this might be right for
Locally Advanced Solid Tumor
Tango Therapeutics, Inc. 110
Early research (Phase 1)Looking for participantsNCT06968572
What this trial is testing

Phase I Study of HSK41959 in Solid Tumors With MTAP Deletion

Who this might be right for
Advanced Solid Tumors
Haisco Pharmaceutical Group Co., Ltd. 245
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