Early research (Phase 1)Active Not RecruitingNCT04794699What this trial is testingStudy of IDE397 in Participants With Solid Tumors Harboring MTAP DeletionWho this might be right forSolid Tumor IDEAYA Biosciences 169
Large-scale testing (Phase 3)Looking for participantsNCT07076121What this trial is testingA Study Comparing BMS-986504 in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)Who this might be right forPancreatic Ductal Adenocarcinoma Bristol-Myers Squibb 470
Testing effectiveness (Phase 2)Looking for participantsNCT06593522What this trial is testingAnvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)Who this might be right forMTAP-deleted NSCLC Amgen 200
Early research (Phase 1)Looking for participantsNCT06360354What this trial is testingA Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)Who this might be right forAdvanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers Amgen 350
Early research (Phase 1)Not Yet RecruitingNCT07469982What this trial is testingA Phase I Study of SY-9453 in Patients With Advanced Solid TumorsWho this might be right forAdvanced or Metastatic Solid Tumors With Homozygous MTAP Deletion Shouyao Holdings (Beijing) Co. LTD 122
Testing effectiveness (Phase 2)Looking for participantsNCT06914128What this trial is testingA First-in-human Study to Learn How Safe BAY 3713372 is and How it Works in Participants With MTAP-deleted Solid TumorsWho this might be right forMTAP-deleted Solid Tumors Bayer 370
Early research (Phase 1)Looking for participantsNCT06968572What this trial is testingPhase I Study of HSK41959 in Solid Tumors With MTAP DeletionWho this might be right forAdvanced Solid Tumors Haisco Pharmaceutical Group Co., Ltd. 245
Early research (Phase 1)Looking for participantsNCT05245500What this trial is testingPhase 1 Study of MRTX1719 in Solid Tumors With MTAP DeletionWho this might be right forMesotheliomaNon Small Cell Lung CancerMalignant Peripheral Nerve Sheath Tumors+3 more Bristol-Myers Squibb 336
Not applicableStudy completedNCT03361358What this trial is testingPre-Screening Study to Identify MTAP Loss in Advanced Solid Tumors or LymphomaWho this might be right forAdvanced Solid TumorsLymphoma Agios Pharmaceuticals, Inc. 44
Early research (Phase 1)Active Not RecruitingNCT06568614What this trial is testingAn Investigational Study of BG-89894 Tablets in Participants With Advanced Solid TumorsWho this might be right forAdvanced or Metastatic MTAP-deleted Solid Tumors BeOne Medicines 29
Testing effectiveness (Phase 2)Looking for participantsNCT06922591What this trial is testingStudy to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC PatientsWho this might be right forPDACPDAC - Pancreatic Ductal AdenocarcinomaNSCLC+5 more Tango Therapeutics, Inc. 183
Early research (Phase 1)Looking for participantsNCT06333951What this trial is testingAnvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).Who this might be right forThoracic TumorsNon-small Cell Lung Cancer Amgen 500
Early research (Phase 1)Looking for participantsNCT06414460What this trial is testingStudy of ISM3412 in Participants With Locally Advanced/Metastatic Solid TumorsWho this might be right forLocally Advanced/Metastatic Solid Tumors InSilico Medicine Hong Kong Limited 80
Very early researchLooking for participantsNCT06883747What this trial is testingClinical Trial of BMS-986504 in Recurrent GBM PatientsWho this might be right forGlioblastoma WHO Grade IV Nader Sanai 9
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07492680What this trial is testingBMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)Who this might be right forSolid Tumors Bristol-Myers Squibb 260
Testing effectiveness (Phase 2)Looking for participantsNCT05732831What this trial is testingSafety and Tolerability of TNG462 in Patients With MTAP-deleted Solid TumorsWho this might be right forLocally Advanced Solid Tumor Tango Therapeutics, Inc. 225
Large-scale testing (Phase 3)Looking for participantsNCT07063745What this trial is testingCompare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP DeletionWho this might be right forMetastatic Non-small Cell Lung Cancer With MTAP Deletion Bristol-Myers Squibb 590
Testing effectiveness (Phase 2)Looking for participantsNCT06188702What this trial is testingS095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAPWho this might be right forMTAP-deleted Solid Tumors Servier Bio-Innovation LLC 342
Very early researchNot Yet RecruitingNCT07485049What this trial is testingPhase 0/2 PD-Trigger Study of BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted TumorsWho this might be right forGlioblastoma (GBM) Nader Sanai 78
Early research (Phase 1)Looking for participantsNCT07277413What this trial is testingIDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid TumorsWho this might be right forNSCLC AdenocarcinomaGastroesophageal Cancer (GC)Gastric Adenocarcinoma+8 more IDEAYA Biosciences 260