Not applicableUnknownNCT04347460What this trial is testingEstablishing a COVID-19 Prospective Cohort for Identification of Secondary HLHWho this might be right forCOVID Technical University of Munich 20
Not applicableStudy completedNCT00002433What this trial is testingThe Effects of r-metHuIFN-Gamma on the Lungs of Patients With AIDSWho this might be right forHIV Infections Amgen 12
Testing effectiveness (Phase 2)Study completedNCT04339712What this trial is testingPersonalised Immunotherapy for SARS-CoV-2 (COVID-19) Associated With Organ DysfunctionWho this might be right forCOVID-19Virus DiseasesMacrophage Activation Syndrome+1 more Hellenic Institute for the Study of Sepsis 102
Not applicableUnknownNCT01095146What this trial is testingNew Candidate Criteria for Diagnosis of Macrophage Activation SyndromeWho this might be right forMacrophage Activation SyndromeLymphohistiocytosis, Hemophagocytic Amrita Institute of Medical Sciences & Research Center 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT01966367What this trial is testingCD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell TransplantationWho this might be right forBone Marrow Failure SyndromeSevere Aplastic AnemiaSevere Congenital Neutropenia+13 more Diane George 37
Testing effectiveness (Phase 2)Study completedNCT03332225What this trial is testingA Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and SepsisWho this might be right forSepsisMacrophage Activation Syndrome Hellenic Institute for the Study of Sepsis 36
Large-scale testing (Phase 3)UnknownNCT05137496What this trial is testingRuxolitinib and Methylprednisolone as a First-line Treatment for Macrophage Activation SyndromeWho this might be right forMacrophage Activation Syndrome Beijing Friendship Hospital 40
Not applicableNot Yet RecruitingNCT07491926What this trial is testingMASKd: a Study on Kawasaki Disease (KD) Complicated by Macrophage Activation Syndrome (MAS)Who this might be right forKawasaki DiseaseMacrophage Activation Syndrome (MAS) Meyer Children's Hospital IRCCS 150
Not applicableStudy completedNCT06405152What this trial is testingAssessment of Macrophage Activation syndromE in STill's DiseaseWho this might be right forMacrophage Activation SyndromeStill's Disease, Adult-OnsetStills Disease, Juvenile-Onset Swedish Orphan Biovitrum 75
Not applicableLooking for participantsNCT07588295What this trial is testingLocal And Systemic Macrophage Activation in Coronary and Peripheral Artery DiseaseWho this might be right forStable Coronary Artery DiseaseAcute Coronary SyndromesCritical Limb Ischemia+1 more Maria Cecilia Hospital 60
Large-scale testing (Phase 3)Study completedNCT05001737What this trial is testingEvaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLEWho this might be right forMacrophage Activation SyndromeSecondary Hemophagocytic LymphohistiocytosisStill Disease+4 more Swedish Orphan Biovitrum 33
Testing effectiveness (Phase 2)Active Not RecruitingNCT02061800What this trial is testingCD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell TransplantWho this might be right forChronic Myeloid Leukemia (CML)Acute Myelogenous Leukemia (AML)Myelodysplastic Syndrome (MDS)+3 more Diane George 14
Not applicableStudy completedNCT02545621What this trial is testingA Role for RAGE/TXNIP/Inflammasome Axis in Alveolar Macrophage Activation During ARDS (RIAMA): a Proof-of-concept Clinical StudyWho this might be right forAcute Respiratory Distress SyndromeMechanical Ventilation University Hospital, Clermont-Ferrand 20
Not applicableLooking for participantsNCT06339177What this trial is testingHemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE StudyWho this might be right forLymphohistiocytosis, HemophagocyticSecondary Hemophagocytic LymphohistiocytosisMacrophage Activation Syndrome+1 more National Institute of Allergy and Infectious Diseases (NIAID) 300
Testing effectiveness (Phase 2)Study completedNCT03311854What this trial is testingInvestigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing Macrophage Activation Syndrome/Secondary HLH (MAS/sHLH)Who this might be right forMacrophage Activation SyndromeLymphohistiocytosis, HemophagocyticArthritis, Juvenile+1 more Swedish Orphan Biovitrum 14
Not applicableLooking for participantsNCT07312474What this trial is testingEpidemiological, Clinical and Biological Characteristics of Human Anaplasmosis Cases in AlsaceWho this might be right forHuman Anaplasmosis University Hospital, Strasbourg, France 100
Testing effectiveness (Phase 2)UnknownNCT02569463What this trial is testingLow-dose IL-2 ( Interleukin-2) Treatment in Macrophage Activation Syndrome（MAS）Who this might be right forMacrophage Activation Syndrome Peking University People's Hospital 6
Testing effectiveness (Phase 2)Active Not RecruitingNCT05611710What this trial is testingAnakinra in Dengue With Hyperinflammation ( AnaDen )Who this might be right forDengueDengue With Warning SignsSevere Dengue+6 more Oxford University Clinical Research Unit, Vietnam 160
Not applicableStudy completedNCT06992505What this trial is testingAssessment of Macrophage Activation syndromE in STill's Disease in ItalyWho this might be right forMacrophage Activation Syndrome (MAS)Still Disease, Juvenile OnsetStill's Disease, Adult-Onset Swedish Orphan Biovitrum 32
Testing effectiveness (Phase 2)Study completedNCT07034209What this trial is testingEvaluate the Efficacy, Safety, Tolerability, Pharmacokinetic Characteristics, and Immunogenicity of Plonmarlimab in Subjects With Rheumatic and Immunological Disease-associated Haemophagocytic Lymphohistiocytosis (HLH) (Also Known as Macrophage Activation Syndrome (MAS))Who this might be right forHemophagocytic Lymphohistiocytoses TJ Biopharma Co., Ltd. 18