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Results for “Metastatic Colorectal Cancer With RAS Mutation”

62 trials

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Showing 20 of 62 results

Testing effectiveness (Phase 2)Looking for participantsNCT06128551
What this trial is testing

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Who this might be right for
Non-Small Cell Lung Cancer (NSCLC)Colorectal CancerPancreatic Ductal Adenocarcinoma
Revolution Medicines, Inc. 534
Testing effectiveness (Phase 2)Looking for participantsNCT06763029
What this trial is testing

Irinotecan Liposomes Combined with Cetuximab + Vermofenib in First-line Failure of Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
Fudan University 36
Testing effectiveness (Phase 2)Enrolling By InvitationNCT06936527
What this trial is testing

XS-03 in Combination With FOLFOX or FOLFIRI and Bevacizumab for Treatment of Metastatic Colorectal Cancer Patients With RAS Mutation

Who this might be right for
Colorectal CancerMetastatic Colorectal Cancer With RAS Mutation
NovaOnco Therapeutics Co., Ltd. 102
Large-scale testing (Phase 3)Looking for participantsNCT06566755
What this trial is testing

Cadonilimab (AK104) Combined With Chemotherapy and Bevacizumab as First-line Treatment for RAS Mutated or Right Sided-metastatic MSS Colorectal Cancer

Who this might be right for
Colorectal Cancer
Caigang Liu 30
Early research (Phase 1)Ended earlyNCT05831995
What this trial is testing

Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

Who this might be right for
Advanced Solid TumorRAS MutationRAF Mutation+1 more
ABM Therapeutics Corporation 12
Testing effectiveness (Phase 2)UnknownNCT05970302
What this trial is testing

XELOX +Bev +Tislelizumab for First-line Treatment of MSS/pMMR RAS-mutated mCRC

Who this might be right for
TislelizumabBevacizumabOxaliplatin+5 more
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 52
Early research (Phase 1)Study completedNCT03597581
What this trial is testing

RGX-202-01 (Ompenaclid) as Combination Therapy in RAS Mutant Advanced Colorectal Cancer

Who this might be right for
Gastrointestinal CancerGastrointestinal NeoplasmsColorectal Cancer+7 more
Inspirna, Inc. 89
Not applicableUnknownNCT02502656
What this trial is testing

RAS Mutation Testing in the Circulating Blood of Patients With Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Association des Gastroentérologues Oncologues 425
Testing effectiveness (Phase 2)Looking for participantsNCT05727163
What this trial is testing

FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients

Who this might be right for
Colorectal Cancer Metastatic
Sun Yat-sen University 194
Testing effectiveness (Phase 2)Looking for participantsNCT06218810
What this trial is testing

Cadonilimab in Combination With Bevacizumab and FOLFOX Regimen for the First-Line Treatment of Advanced Unresectable MSS-Type, RAS-Mutated Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal CancerMicrosatellite Stable Colorectal CarcinomaRAS Mutation+1 more
Fudan University 53
Testing effectiveness (Phase 2)Ended earlyNCT02175654
What this trial is testing

Regorafenib as Single Agent in Patients With Metastatic Colorectal Cancer (mCRC) With Any RAS or BRAF Mutation Previously Treated With FOLFOXIRI Plus Bevacizumab

Who this might be right for
Colorectal NeoplasmsMetastatic Disease
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) 15
Testing effectiveness (Phase 2)Looking for participantsNCT05379985
What this trial is testing

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)Pancreatic Ductal Adenocarcinoma (PDAC)+1 more
Revolution Medicines, Inc. 754
Large-scale testing (Phase 3)Active Not RecruitingNCT05171660
What this trial is testing

Combination With Sintilimab and XELOX+Bevacizumab as 1st Line Therapy in RAS-mutant Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer Stage IV
Second Affiliated Hospital, Zhejiang University, School of Medicine 446
Testing effectiveness (Phase 2)Study completedNCT01298570
What this trial is testing

Regorafenib+FOLFIRI Versus Placebo+FOLFIRI as 2nd Line Tx in Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
UNC Lineberger Comprehensive Cancer Center 181
Testing effectiveness (Phase 2)Study completedNCT05593328
What this trial is testing

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation

Who this might be right for
Colorectal CancerMetastatic Colorectal Cancer
Cardiff Oncology 23
Testing effectiveness (Phase 2)Looking for participantsNCT07213570
What this trial is testing

STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
National Cancer Institute, Naples 60
Large-scale testing (Phase 3)Active Not RecruitingNCT04793958
What this trial is testing

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Who this might be right for
Advanced Colorectal CancerMetastatic Colorectal Cancer
Mirati Therapeutics Inc. 461
Testing effectiveness (Phase 2)Looking for participantsNCT07020221
What this trial is testing

VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Who this might be right for
Pancreatic Ductal AdenocarcinomaNon Small Cell Lung CancerColorectal Cancer+2 more
Verastem, Inc. 295
Testing effectiveness (Phase 2)Looking for participantsNCT06321081
What this trial is testing

ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC

Who this might be right for
RAS MutationMetastatic Colorectal CancerMSS
Beijing Hospital 60
Large-scale testing (Phase 3)Looking for participantsNCT06226857
What this trial is testing

Other Oncogene Mutations for Anti-EGFR Efficacy in Patients With Left-sided RAS-wild Type Metastatic Colorectal Cancer

Who this might be right for
Colorectal NeoplasmsChemotherapy EffectMolecular Sequence Variation
City Clinical Oncology Hospital No 1 355
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