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Results for “Molecular Mechanisms of Pharmacological Action”

141 trials

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Showing 20 of 141 results

Testing effectiveness (Phase 2)Ended earlyNCT01555489
What this trial is testing

Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca

Who this might be right for
Stage IV Pancreatic Cancer
Thomas Jefferson University 11
Large-scale testing (Phase 3)Active Not RecruitingNCT04784715
What this trial is testing

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Who this might be right for
Breast Cancer; HER2-positive; Metastatic
AstraZeneca 1,157
Testing effectiveness (Phase 2)Active Not RecruitingNCT04699188
What this trial is testing

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Who this might be right for
KRAS G12C Mutant Solid TumorsCarcinoma, Non-Small-Cell LungCarcinoma, Colorectal+7 more
Novartis Pharmaceuticals 344
Large-scale testing (Phase 3)Looking for participantsNCT07555483
What this trial is testing

A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)

Who this might be right for
Alpha 1 Antitrypsin Deficiency
Grifols Therapeutics LLC 40
Large-scale testing (Phase 3)Study completedNCT01701401
What this trial is testing

Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination (FDC) With and Without Ribavirin for the Treatment of HCV

Who this might be right for
Chronic Hepatitis C Virus
Gilead Sciences 870
Post-approval studies (Phase 4)Study completedNCT01201811
What this trial is testing

Study of Azacitidine in Adult Taiwanese Subjects With Higher-Risk Myelodysplastic Syndromes (MDS)

Who this might be right for
Myelodysplastic Syndromes
Celgene 44
Not applicableApproved For MarketingNCT01779518
What this trial is testing

Expanded Access Program of Sofosbuvir With Ribavirin and With or Without Pegylated Interferon in Aggressive Post-transplant Hepatitis C

Who this might be right for
Post-transplant Hepatitis C
Gilead Sciences
Early research (Phase 1)Ended earlyNCT05788328
What this trial is testing

A Drug-Drug Interaction Study to Estimate the Effect of PF-07081532 on the Pharmacokinetics of Dabigatran and Rosuvastatin in Overweight or Obese Adult Participants

Who this might be right for
Healthy
Pfizer 16
Testing effectiveness (Phase 2)Study completedNCT01507103
What this trial is testing

Tecemotide (L-BLP25) in Rectal Cancer

Who this might be right for
Rectal Cancer
Merck KGaA, Darmstadt, Germany 124
Testing effectiveness (Phase 2)Looking for participantsNCT06511908
What this trial is testing

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

Who this might be right for
SuicideDepressive Disorder, Treatment-ResistantKetamine+10 more
National Institute of Mental Health (NIMH) 50
Large-scale testing (Phase 3)Study completedNCT04334148
What this trial is testing

Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine

Who this might be right for
COVID-19
Adrian Hernandez 1,360
Not applicableStudy completedNCT03188601
What this trial is testing

Α1-antitrypsin (AAT) Levels and Functions in Allogeneic Bone Marrow Transplantation and Throughout Progression Into GVHD

Who this might be right for
GVHDBone Marrow Transplant FailureAlpha 1-Antitrypsin
Rambam Health Care Campus 27
Testing effectiveness (Phase 2)UnknownNCT04556071
What this trial is testing

Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer

Who this might be right for
Ovarian NeoplasmsFallopian Tube NeoplasmsEndocrine Gland Neoplasms+21 more
Xiaoxiang Chen 32
Early research (Phase 1)Study completedNCT02012166
What this trial is testing

MK-0893 on Glucagon-Induced Glycemic Excursion in Healthy Male Participants Following Intravenous Administration of Glucagon, Sandostatine® and Insulin (MK-0893-002)

Who this might be right for
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC 18
Large-scale testing (Phase 3)Active Not RecruitingNCT05113251
What this trial is testing

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

Who this might be right for
Breast NeoplasmsBreast CancerHER2-positive Early Breast Cancer
AstraZeneca 927
Early research (Phase 1)Looking for participantsNCT06796361
What this trial is testing

Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness

Who this might be right for
Healthy
University Hospital, Basel, Switzerland 16
Not applicableUnknownNCT04169230
What this trial is testing

Citalopram and Self Emotional Processing

Who this might be right for
Molecular Mechanisms of Pharmacological ActionDepressionDepressive Disorder+3 more
University of Oxford 44
Large-scale testing (Phase 3)UnknownNCT01204801
What this trial is testing

Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors

Who this might be right for
Breast Cancer
Medifocus, Inc. 238
Testing effectiveness (Phase 2)Ended earlyNCT04575610
What this trial is testing

IRAK4 Inhibition in Treatment of COVID-19 With ARDS (I-RAMIC)

Who this might be right for
COVID-19
Yale University 7
Testing effectiveness (Phase 2)Ended earlyNCT02227368
What this trial is testing

Walking Effect of Long Term Ticagrelor in Subjects With PAD Who Have Undergone EVR

Who this might be right for
Peripheral Artery Disease (PAD)
AstraZeneca 40
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