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Results for “Myelodysplastic Syndrome With Gene Mutation”

57 trials

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Showing 20 of 57 results

Early research (Phase 1)Looking for participantsNCT06543381
What this trial is testing

Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant

Who this might be right for
Acute Myeloid LeukemiaChronic Myelomonocytic LeukemiaMyelodysplastic Syndrome
City of Hope Medical Center 15
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple Myeloma+1 more
Sumitomo Pharma America, Inc. 606
Testing effectiveness (Phase 2)Study completedNCT00102687
What this trial is testing

Alternative Dosing Regimens of Subcutaneous Azacitidine for Myelodysplastic Syndromes

Who this might be right for
Myelodysplastic Syndromes
Celgene 151
Not applicableUnknownNCT01331603
What this trial is testing

Assessment of Labile Plasma Iron (LPI) in Myelodysplastic Syndromes (MDS) and Primary Myelofibrosis

Who this might be right for
Myelodysplastic SyndromePrimary Myelofibrosis
Wolfson Medical Center 50
Testing effectiveness (Phase 2)Looking for participantsNCT06577441
What this trial is testing

Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

Who this might be right for
Myelodysplastic Syndrome
National Cancer Institute (NCI) 54
Large-scale testing (Phase 3)Looking for participantsNCT06465953
What this trial is testing

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

Who this might be right for
Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)Myelodysplastic Syndromes (MDS)
Institut de Recherches Internationales Servier 48
Early research (Phase 1)Not Yet RecruitingNCT07753148
What this trial is testing

Safety and Tolerability of REGN17235 in Adult Participants With Clonal Cytopenia of Undetermined Significance and Low-Risk Myelodysplastic Syndrome With SF3B1 Mutation

Who this might be right for
Clonal Cytopenia of Undetermined Significance (CCUS)Low-Risk Myelodysplastic Syndrome (LR-MDS)
Regeneron Pharmaceuticals 52
Testing effectiveness (Phase 2)Looking for participantsNCT03383575
What this trial is testing

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

Who this might be right for
Acute Myeloid LeukemiaBlasts 20-30 Percent of Bone Marrow Nucleated CellsChronic Myelomonocytic Leukemia+4 more
M.D. Anderson Cancer Center 63
Testing effectiveness (Phase 2)Active Not RecruitingNCT03953898
What this trial is testing

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAcute Myeloid Leukemia Post Cytotoxic Therapy+4 more
National Cancer Institute (NCI) 14
Not applicableStudy completedNCT02060409
What this trial is testing

Prognostic Molecular Markers in Patients With Myelodysplastic Syndrome

Who this might be right for
Myelodysplastic Syndrome
Samsung Medical Center 58
Not applicableStudy completedNCT03894852
What this trial is testing

SRSF2 Gene Mutation in Patients With t-MDS/AML

Who this might be right for
Therapy Related Myelodysplastic Syndrome and Therapy Related Acute Myeloid Leukemia
Zeinab Albadry Mohammed Zahran 139
Testing effectiveness (Phase 2)Ended earlyNCT01028716
What this trial is testing

Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Who this might be right for
Acute Biphenotypic LeukemiaAcute Erythroid Leukemia in RemissionAcute Leukemia in Remission+27 more
Fred Hutchinson Cancer Center 46
Not applicableStudy completedNCT04212390
What this trial is testing

Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care

Who this might be right for
MDS (Myelodysplastic Syndrome)
Fondazione Italiana Sindromi Mielodisplastiche-ETS 1,000
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
Not applicableNot Yet RecruitingNCT07108023
What this trial is testing

Hematological Disorders in EHPVO Patients

Who this might be right for
Extrahepatic Portal Vein Obstruction (EHPVO)ThrombophiliaMyeloproliferative Neoplasms (MPN)+5 more
Rahab Nady 115
Not applicableLooking for participantsNCT06022016
What this trial is testing

Study of Families With an Hemopathies Predisposition Related to the DDX41 Gene.

Who this might be right for
DDX41 Gene Mutation
Institut Claudius Regaud 910
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
Testing effectiveness (Phase 2)Looking for participantsNCT03683433
What this trial is testing

Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

Who this might be right for
Acute Bilineal LeukemiaAcute Biphenotypic LeukemiaChronic Myelomonocytic Leukemia+4 more
M.D. Anderson Cancer Center 50
Not applicableLooking for participantsNCT07019155
What this trial is testing

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

Who this might be right for
Germline MutationMyelodysplastic SyndromesAcute Myeloid Leukemia
National Cancer Institute (NCI) 510
Testing effectiveness (Phase 2)Ended earlyNCT03333486
What this trial is testing

Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

Who this might be right for
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveAcute Leukemia in RemissionAcute Lymphoblastic Leukemia+34 more
Roswell Park Cancer Institute 31
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