Not applicableStudy completedNCT04856540What this trial is testingAdult Outcomes of Children With CAPSWho this might be right forCryopyrin Associated Periodic Syndrome University Hospital, Lille 54
Testing effectiveness (Phase 2)Looking for participantsNCT07157735What this trial is testingA Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's DiseaseWho this might be right forParkinson Disease Cambridge University Hospitals NHS Foundation Trust 36
Not applicableUnknownNCT04814147What this trial is testingRole NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese PatientsWho this might be right forObesity MorbidObesity-Associated Insulin Resistance University Hospital Center of Martinique 20
Large-scale testing (Phase 3)Study completedNCT00685373What this trial is testingEfficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory DiseaseWho this might be right forCryopyrin-Associated Periodic SyndromesFamilial Cold Autoinflammatory SyndromeMuckle Wells Syndrome+1 more Novartis 166
Not applicableStudy completedNCT04728165What this trial is testingAnti-Inflammatory Effects of Time-Restricted FeedingWho this might be right forPsoriasisSystemic Inflammation National Heart, Lung, and Blood Institute (NHLBI) 27
Testing effectiveness (Phase 2)Ended earlyNCT02853084What this trial is testingHL2351 CAPS Phase II StudyWho this might be right forCryopyrin-Associated Periodic Syndromes (CAPS) Handok Inc. 8
Testing effectiveness (Phase 2)Looking for participantsNCT06836232What this trial is testingAn Open-Label Pilot Study of VTX2735 in Recurrent PericarditisWho this might be right forRecurrent Pericarditis Zomagen Biosciences Ltd. 50
Not applicableUnknownNCT05077007What this trial is testingEvaluation of Renal Damage After PCNL and ESWL Using Novel RNA Based BiomarkersWho this might be right forAcute Kidney InjuryRenal CalculiPercutaneous Nephrolithotomy+1 more Ain Shams University 75
Early research (Phase 1)Study completedNCT04086602What this trial is testingSafety and Tolerability, Pharmacokinetic and Pharmacodynamic Study With IZD334Who this might be right forHealthy VolunteersCryopyrin Associated Periodic Syndrome Inflazome UK Ltd 64
Not applicableActive Not RecruitingNCT07563192What this trial is testingEvaluation of the Effect of Smoking on Pyroptosis in Periodontal PathogenesisWho this might be right forPeriodontitisGingivitisPeriodontal Diseases+1 more Suleyman Demirel University 113
Large-scale testing (Phase 3)Study completedNCT01105507What this trial is testingThe Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in CanadaWho this might be right forCryopyrin Associated Periodic Syndrome Novartis Pharmaceuticals 4
Testing effectiveness (Phase 2)Study completedNCT05781698What this trial is testingRepurposing Fenofibrate in Modulating mTOR/NLRP3 Inflammasome in Patients With Ulcerative ColitisWho this might be right forInflammatory Bowel Diseases Tanta University 60
Early research (Phase 1)Looking for participantsNCT06974877What this trial is testingRepeat PET/CT Imaging in People With CAPS and Anakinra-Induced Amyloidosis Using an Amyloid-Reactive Peptide to Measure Changes in Organ-Specific Amyloid LoadWho this might be right forCryopyrin-Associated Periodic SyndromesAmyloidosis National Institute of Allergy and Infectious Diseases (NIAID) 30
Post-approval studies (Phase 4)Study completedNCT05130892What this trial is testingEffect of Inflammasome Inhibitor on hsCRP in Patients After PCIWho this might be right forNLRP3hsCRPPercutaneous Coronary Intervention Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 132
Testing effectiveness (Phase 2)Study completedNCT06771115What this trial is testingPhase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in ObesityWho this might be right forObesity Zomagen Biosciences Ltd. 176
Not applicableActive Not RecruitingNCT07232238What this trial is testingTRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo PatientsWho this might be right forVitiligo Aswan University 60
Post-approval studies (Phase 4)Not Yet RecruitingNCT07763665What this trial is testingAnti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein ComplexWho this might be right forTraumatic Brain Injuries Assiut University 64
Large-scale testing (Phase 3)Study completedNCT00288704What this trial is testingRilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)Who this might be right forFamilial Cold Autoinflammatory Syndrome (FCAS)Familial Cold UrticariaMuckle-Wells Syndrome (MWS)+1 more Regeneron Pharmaceuticals 104
Large-scale testing (Phase 3)Study completedNCT01576367What this trial is testingEfficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory DiseaseWho this might be right forCryopyrin-associated Periodic SyndromesFamilial Cold Autoinflammatory SyndromeMuckle-Wells Syndrome+1 more Novartis Pharmaceuticals 17
Not applicableStudy completedNCT04766814What this trial is testingEpigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and ControlsWho this might be right forAtrial FibrillationArrhythmia Tulane University 29