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Results for “Newly Diagnosed MGMT Unmethylated Glioblastoma”

34 trials

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Showing 20 of 34 results

Large-scale testing (Phase 3)Looking for participantsNCT03970447
What this trial is testing

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Who this might be right for
Glioblastoma
Global Coalition for Adaptive Research 2,250
Testing effectiveness (Phase 2)Study completedNCT03522298
What this trial is testing

Safety, Pharmacokinetics and Efficacy of Paxalisib (GDC-0084) in Newly-diagnosed Glioblastoma

Who this might be right for
Glioblastoma, Adult
Kazia Therapeutics Limited 30
Testing effectiveness (Phase 2)Looking for participantsNCT07326566
What this trial is testing

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Who this might be right for
Glioblastoma (GBM)Newly Diagnosed GlioblastomaGBM+4 more
Black Diamond Therapeutics, Inc. 162
Testing effectiveness (Phase 2)Looking for participantsNCT06504381
What this trial is testing

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

Who this might be right for
High Grade GliomaMGMT-Unmethylated GlioblastomaMGMT-Methylated Glioblastoma
University of California, San Francisco 70
Testing effectiveness (Phase 2)UnknownNCT06186440
What this trial is testing

Cisplatin Plus Temozolomide Compared With Temozolomide in Patients With MGMT Promotor Unmethylated Glioblastoma

Who this might be right for
Glioblastoma Multiforme of Brain
Zhongnan Hospital 60
Testing effectiveness (Phase 2)UnknownNCT05033587
What this trial is testing

Study of AK105 With Anlotinib and Radiotherapy Adjuvant Therapy in MGMT Unmethylated Newly Diagnosed Glioblastoma.

Who this might be right for
MGMT-Unmethylated Glioblastoma
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 28
Testing effectiveness (Phase 2)UnknownNCT02928575
What this trial is testing

Combining Sunitinib, Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma

Who this might be right for
Glioblastoma Multiforme
Bassam Abdulkarim 45
Testing effectiveness (Phase 2)Study completedNCT03367715
What this trial is testing

Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma

Who this might be right for
MGMT-unmethylated Glioblastoma (GBM)GBM
NYU Langone Health 10
Early research (Phase 1)Ended earlyNCT03107780
What this trial is testing

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Who this might be right for
GlioblastomaGliosarcomaMGMT-Unmethylated Glioblastoma+1 more
National Cancer Institute (NCI) 32
Testing effectiveness (Phase 2)Looking for participantsNCT05879250
What this trial is testing

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma, IDH-WildtypeMGMT-Unmethylated Glioblastoma
Northwestern University 39
Early research (Phase 1)Active Not RecruitingNCT05743595
What this trial is testing

Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

Who this might be right for
Unmethylated Glioblastoma
Washington University School of Medicine 27
Large-scale testing (Phase 3)Looking for participantsNCT06388733
What this trial is testing

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Who this might be right for
GlioblastomaGBMBrain Neoplasms, Adult, Malignant+1 more
Ivy Brain Tumor Center 450
Large-scale testing (Phase 3)Not Yet RecruitingNCT07452458
What this trial is testing

Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma

Who this might be right for
Glioblastoma, IDH-WildtypeMGMT-Unmethylated Glioblastoma
NRG Oncology 398
Early research (Phase 1)Looking for participantsNCT07343986
What this trial is testing

Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma

Who this might be right for
Glioblastoma (GBM)
University of Virginia 12
Testing effectiveness (Phase 2)Study completedNCT03050736
What this trial is testing

Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression

Who this might be right for
GliomaGlioblastomaGlioblastoma Multiforme+2 more
Kintara Therapeutics, Inc. 29
Testing effectiveness (Phase 2)Looking for participantsNCT06991101
What this trial is testing

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Who this might be right for
GlioblastomaBrain CancerGlioblastoma Multiforme+4 more
Baptist Health South Florida 190
Testing effectiveness (Phase 2)Looking for participantsNCT05734560
What this trial is testing

D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

Who this might be right for
Newly Diagnosed MGMT Unmethylated Glioblastoma
Darell Bigner 50
Large-scale testing (Phase 3)Study completedNCT02617589
What this trial is testing

An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)

Who this might be right for
Brain Cancer
Bristol-Myers Squibb 560
Testing effectiveness (Phase 2)Study completedNCT00813943
What this trial is testing

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status

Who this might be right for
Glioblastoma
EMD Serono 265
Testing effectiveness (Phase 2)Looking for participantsNCT07476794
What this trial is testing

Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma

Who this might be right for
Glioblastoma
Sunnybrook Health Sciences Centre 118
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