Early research (Phase 1)Study completedNCT03559751What this trial is testingEvaluation of the Abuse Liability of Very Low Nicotine (VLN) CigarettesWho this might be right forTobacco Use 22nd Century Group, Inc. 66
Testing effectiveness (Phase 2)Study completedNCT02698215What this trial is testingCombining Varenicline and Naltrexone for Smoking CessationWho this might be right forNicotine DependenceAlcohol Use Disorder University of California, Los Angeles 165
Not applicableLooking for participantsNCT06239350What this trial is testingYoung Adult Tobacco/Nicotine and Cannabis Co-useWho this might be right forTobacco Use DisorderNicotine Dependence Medical University of South Carolina 350
Not applicableStudy completedNCT05134415What this trial is testingUse Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS ConsumersWho this might be right forElectronic Cigarette Use Cheerain HK Limited 40
Testing effectiveness (Phase 2)Study completedNCT01001520What this trial is testingNeural Substrates in Nicotine WithdrawalWho this might be right forTobacco Use Disorder University of Pennsylvania 218
Not applicableNot Yet RecruitingNCT07785479What this trial is testingEffectiveness of Oral Nicotine Pouches as a Cessation Tool Among Adult Tobacco Users in PakistanWho this might be right forTobacco CessationSmoking Cessation Cyntax Health Projects PVT LTD 148
Post-approval studies (Phase 4)Study completedNCT04126135What this trial is testingComparative Effectiveness of Cystine Versus Nicotine Replacement TherapyWho this might be right forNicotine Addiction Loma Linda University 1,307
Not applicableLooking for participantsNCT04163081What this trial is testingThe INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency DepartmentsWho this might be right forNicotine Dependence, CigarettesNicotine Withdrawal Ottawa Heart Institute Research Corporation 1,208
Testing effectiveness (Phase 2)Study completedNCT02250534What this trial is testingProject 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age WomenWho this might be right forTobacco Use Disorder University of Vermont 775
Not applicableUnknownNCT05193630What this trial is testingIntervention Study to Investigate the Effects of ONS Use Among Malaysian Children With Faltering GrowthWho this might be right forFaltering Growth Danone Specialized Nutrition (M) Sdn Bhd 172
Not applicableStudy completedNCT03113136What this trial is testingExamination of Low Wattage and High Wattage E-CigarettesWho this might be right forSmoking, CigaretteSmoking, TobaccoNicotine Dependence+1 more Ohio State University Comprehensive Cancer Center 372
Not applicableEnded earlyNCT02986711What this trial is testingPenn State TXT2STAYQUIT Study- a Texting Study to Help Hospitalized Smokers Stay QuitWho this might be right forNicotine Dependence, Cigarettes Milton S. Hershey Medical Center 158
Early research (Phase 1)Study completedNCT01337830What this trial is testingPilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in SmokersWho this might be right forTobacco Use DisorderSmoking Star Scientific, Inc 111
Early research (Phase 1)Study completedNCT01574898What this trial is testingPilot Pharmacokinetic Study of New Nicotine Lozenge FormulationsWho this might be right forHealthy Smokers Pierre Fabre Medicament 13
Not applicableNot Yet RecruitingNCT06553196What this trial is testingMATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience EducationWho this might be right forAlcohol UseCannabis UseNicotine Use+2 more California State University, Northridge 1,000
Not applicableStudy completedNCT01526005What this trial is testingBrain Nicotine Receptor Density & Response to Nicotine PatchWho this might be right forCigarette Smoking Brentwood Biomedical Research Institute 50
Post-approval studies (Phase 4)Ended earlyNCT04602494What this trial is testingVarenicline For Nicotine Vaping Cessation In Non Smoker Vaper AdolescentsWho this might be right forVapingNicotine Dependence Massachusetts General Hospital 5
Not applicableStudy completedNCT03839745What this trial is testingShort-Term Cardiovascular Effects of E-Cigarettes: Influence of Device PowerWho this might be right forCardiovascular Risk FactorNicotine Dependence University of California, San Francisco 16
Large-scale testing (Phase 3)Study completedNCT02521662What this trial is testingThe Use of Nicotine Patches Together With E-cigarettes (With and Without Nicotine) for Smoking CessationWho this might be right forSmoking Cessation University of Auckland, New Zealand 1,124
Early research (Phase 1)Study completedNCT00136786What this trial is testingEffect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3Who this might be right forTobacco Use Disorder New York State Psychiatric Institute 25