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Results for “Noonan Syndrome”

50 trials

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Showing 20 of 50 results

Early research (Phase 1)Active Not RecruitingNCT01787500
What this trial is testing

Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery

Who this might be right for
BRAF NP_004324.2:p.V600XKRAS wt AlleleMetastatic Malignant Solid Neoplasm+4 more
M.D. Anderson Cancer Center 33
Not applicableLooking for participantsNCT06455956
What this trial is testing

Use of miRNAs in Growth Hormone Deficiency (GHD)

Who this might be right for
Growth Hormone Deficiency
University of Parma 400
Not applicableLooking for participantsNCT04888936
What this trial is testing

Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies

Who this might be right for
Costello SyndromeNoonan SyndromeCardiofaciocutaneous Syndrome+3 more
National Cancer Institute (NCI) 500
Early research (Phase 1)Active Not RecruitingNCT04670679
What this trial is testing

A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced or Metastatic Solid Tumors
Erasca, Inc. 200
Early research (Phase 1)Study completedNCT03518554
What this trial is testing

A First in Human, Dose Escalation Study of JAB-3068 （SHP2 Inhibitor） in Adult Patients With Advanced Solid Tumors

Who this might be right for
Non-small Cell Lung CancerHead and Neck CancerEsophageal Cancer+1 more
Jacobio Pharmaceuticals Co., Ltd. 38
Early research (Phase 1)Study completedNCT04045496
What this trial is testing

A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid Tumors

Who this might be right for
Non-small Cell Lung CancerColorectal CancerPancreatic Ductal Carcinoma+4 more
Jacobio Pharmaceuticals Co., Ltd. 40
Not applicableLooking for participantsNCT05202210
What this trial is testing

Constitution of a Biological Collection to Study the Pathophysiology in Noonan Syndrome

Who this might be right for
Noonan Syndrome
University Hospital, Toulouse 100
Not applicableLooking for participantsNCT06147414
What this trial is testing

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

Who this might be right for
Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, IncludingSickle Cell DiseaseCystic Fibrosis+12 more
Assistance Publique - Hôpitaux de Paris 550
Not applicableLooking for participantsNCT04463316
What this trial is testing

GROWing Up With Rare GENEtic Syndromes

Who this might be right for
Prader-Willi SyndromePWS-like SyndromeSilver Russel Syndrome+30 more
dr. Laura C. G. de Graaff-Herder 600
Large-scale testing (Phase 3)Study completedNCT01927861
What this trial is testing

Investigating the Long-term Efficacy and Safety of Two Doses of NN-220 (Somatropin) in Short Stature Due to Noonan Syndrome

Who this might be right for
Genetic DisorderNoonan Syndrome
Novo Nordisk A/S 51
Testing effectiveness (Phase 2)Looking for participantsNCT06668805
What this trial is testing

Basket Study of Vosoritide in Children With Turner Syndrome, SHOX Deficiency and Noonan Syndrome With an Inadequate Response to Human Growth Hormone

Who this might be right for
Short Stature Homeobox- Containing Gene SHOX DeficiencyNoonan SyndromeTurner Syndrome
BioMarin Pharmaceutical 72
Not applicableLooking for participantsNCT05361811
What this trial is testing

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

Who this might be right for
Neurofibromatosis 1Noonan SyndromeLegius Syndrome+2 more
National Cancer Institute (NCI) 70
Large-scale testing (Phase 3)Study completedNCT00452725
What this trial is testing

Effect of MAXOMAT ® on the Growth of Small Children to NOONAN's Syndrome

Who this might be right for
Noonan Syndrome
Sanofi 36
Testing effectiveness (Phase 2)Study completedNCT03565003
What this trial is testing

A First-in-Human Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors in China

Who this might be right for
Non-small Cell Lung CancerHead and Neck CancerEsophageal Cancer+1 more
Jacobio Pharmaceuticals Co., Ltd. 126
Testing effectiveness (Phase 2)Ended earlyNCT03504501
What this trial is testing

Synaptic Plasticity and Cognitive Function in RASopathies

Who this might be right for
Impaired Synaptic PlasticityImpaired Cognition
Technical University of Munich 16
Testing effectiveness (Phase 2)Ended earlyNCT02587650
What this trial is testing

Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma

Who this might be right for
ALK Fusion Protein ExpressionBRAF wt AlleleInvasive Skin Melanoma+12 more
University of California, San Francisco 1
Not applicableStudy completedNCT06267807
What this trial is testing

Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders

Who this might be right for
Lymphatic System Disorders CongenitalLymphatic DiseasesNoonan Syndrome+1 more
Radboud University Medical Center 9
Early research (Phase 1)Study completedNCT04121286
What this trial is testing

JAB-3312 in Adult Patients With Advanced Solid Tumors in China

Who this might be right for
Non-small Cell Lung CancerColorectal CancerPancreatic Ductal Carcinoma+4 more
Allist Pharmaceuticals, Inc. 17
Not applicableLooking for participantsNCT05761314
What this trial is testing

Solid Tumors in RASopathies

Who this might be right for
RASopathyCostello SyndromeCardio-Facio-Cutaneous Syndrome+1 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 100
Testing effectiveness (Phase 2)UnknownNCT05715398
What this trial is testing

BR790 in Combination With Anlotinib in Adult Subjects With Advanced Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
Shanghai Gopherwood Biotech Co., Ltd. 90
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