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Results for “Noonan Syndrome”

52 trials

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Showing 20 of 52 results

Early research (Phase 1)Study completedNCT03518554
What this trial is testing

A First in Human, Dose Escalation Study of JAB-3068 （SHP2 Inhibitor） in Adult Patients With Advanced Solid Tumors

Who this might be right for
Non-small Cell Lung CancerHead and Neck CancerEsophageal Cancer+1 more
Jacobio Pharmaceuticals Co., Ltd. 38
Not applicableStudy completedNCT02486731
What this trial is testing

Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes

Who this might be right for
Noonan SyndromeLEOPARD Syndrome
Institut National de la Santé Et de la Recherche Médicale, France 27
Not applicableLooking for participantsNCT05361811
What this trial is testing

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

Who this might be right for
Neurofibromatosis 1Noonan SyndromeLegius Syndrome+2 more
National Cancer Institute (NCI) 70
Not applicableStudy completedNCT00960128
What this trial is testing

Observational Prospective Study on Patients Treated With Norditropin®

Who this might be right for
Growth Hormone DisorderGrowth Hormone Deficiency in ChildrenAdult Growth Hormone Deficiency+7 more
Novo Nordisk A/S 21,249
Testing effectiveness (Phase 2)Ended earlyNCT03504501
What this trial is testing

Synaptic Plasticity and Cognitive Function in RASopathies

Who this might be right for
Impaired Synaptic PlasticityImpaired Cognition
Technical University of Munich 16
Large-scale testing (Phase 3)Study completedNCT01529944
What this trial is testing

Genetic Testing of Noonan Subjects Previously Treated With Norditropin®. An Extension to Trial GHNOO-1658

Who this might be right for
Genetic DisorderNoonan Syndrome
Novo Nordisk A/S 22
Large-scale testing (Phase 3)Study completedNCT02713945
What this trial is testing

Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome

Who this might be right for
Noonan Syndrome
University Hospital, Toulouse 53
Not applicableLooking for participantsNCT03050268
What this trial is testing

Familial Investigations of Childhood Cancer Predisposition

Who this might be right for
Acute LeukemiaAdenomatous PolyposisAdrenocortical Carcinoma+43 more
St. Jude Children's Research Hospital 1,500
Not applicableStudy completedNCT02383316
What this trial is testing

Study of Metabolic Modifications in Children With Noonan Syndrome

Who this might be right for
Child Syndrome
University Hospital, Toulouse 20
Not applicableLooking for participantsNCT07464821
What this trial is testing

National Multicentre Study on Lipid Profile in Noonan Syndrome and Related Disorders: Trends by Age, Gender and Genotype

Who this might be right for
RASopathiesNoonan Syndrome
IRCCS Azienda Ospedaliero-Universitaria di Bologna 200
Early research (Phase 1)Study completedNCT04959981
What this trial is testing

Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC

Who this might be right for
Advanced Non-squamous Non-small-cell Lung Cancer
Erasca, Inc. 24
Early research (Phase 1)Study completedNCT04121286
What this trial is testing

JAB-3312 in Adult Patients With Advanced Solid Tumors in China

Who this might be right for
Non-small Cell Lung CancerColorectal CancerPancreatic Ductal Carcinoma+4 more
Allist Pharmaceuticals, Inc. 17
Testing effectiveness (Phase 2)Ended earlyNCT02587650
What this trial is testing

Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma

Who this might be right for
ALK Fusion Protein ExpressionBRAF wt AlleleInvasive Skin Melanoma+12 more
University of California, San Francisco 1
Testing effectiveness (Phase 2)WithdrawnNCT01556568
What this trial is testing

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic Cardiomyopathy

Who this might be right for
Cardiomegaly
Array Biopharma, now a wholly owned subsidiary of Pfizer
Testing effectiveness (Phase 2)Active Not RecruitingNCT04219007
What this trial is testing

Vosoritide for Selected Genetic Causes of Short Stature

Who this might be right for
Short Stature
Andrew Dauber 56
Testing effectiveness (Phase 2)Looking for participantsNCT06668805
What this trial is testing

Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment

Who this might be right for
Noonan Syndrome
BioMarin Pharmaceutical 30
Early research (Phase 1)Study completedNCT04045496
What this trial is testing

A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid Tumors

Who this might be right for
Non-small Cell Lung CancerColorectal CancerPancreatic Ductal Carcinoma+4 more
Jacobio Pharmaceuticals Co., Ltd. 40
Not applicableStudy completedNCT06267807
What this trial is testing

Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders

Who this might be right for
Lymphatic System Disorders CongenitalLymphatic DiseasesNoonan Syndrome+1 more
Radboud University Medical Center 9
Not applicableLooking for participantsNCT05761314
What this trial is testing

Solid Tumors in RASopathies

Who this might be right for
RASopathyCostello SyndromeCardio-Facio-Cutaneous Syndrome+1 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 100
Early research (Phase 1)Study completedNCT01787500
What this trial is testing

Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery

Who this might be right for
BRAF NP_004324.2:p.V600XKRAS wt AlleleMetastatic Malignant Solid Neoplasm+4 more
M.D. Anderson Cancer Center 47
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