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Results for “Novel Mutation”

64 trials

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Showing 20 of 64 results

Not applicableUnknownNCT02319382
What this trial is testing

Measure of Microglial Activation in the Brain of Parkinson Disease Patients With PET

Who this might be right for
Parkinson's Disease With LRRK2 MutationHealthy ControlsParkinson's Disease Without LRRK2 Mutation
Assistance Publique - Hôpitaux de Paris 46
Testing effectiveness (Phase 2)Looking for participantsNCT07007949
What this trial is testing

A New Treatment of Newly Diagnosed IDH1 Mutation Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaIDH1 Gene MutationIvosidenib
The First Affiliated Hospital of Soochow University 42
Not applicableActive Not RecruitingNCT06863818
What this trial is testing

Overcoming Resistance to EGFR Neutralization by Combination of Monoclonal Antibodies and Novel Cancer Drugs

Who this might be right for
Non Small Cell Lung Cancer
IRCCS Azienda Ospedaliero-Universitaria di Bologna 30
Not applicableLooking for participantsNCT04658251
What this trial is testing

Study of New Mutations in Cone Disorders

Who this might be right for
Retinal Dystrophy, Cone-RodCone DystrophyCone Rod Dystrophy+1 more
University Hospital, Lille 20
Large-scale testing (Phase 3)Ended earlyNCT00612898
What this trial is testing

Study of the Efficacy and Safety of Apricitabine, a New NRTI, to Treat Drug-resistant HIV Infection

Who this might be right for
HIV Infections
Avexa 239
Not applicableStudy completedNCT02194881
What this trial is testing

Ivacaftor in French Patients With Cystic Fibrosis and a G551D Mutation

Who this might be right for
Cystic Fibrosis
Assistance Publique - Hôpitaux de Paris 57
Early research (Phase 1)WithdrawnNCT02758730
What this trial is testing

Study Assessing Tolerability and Safety and Exploring the Immunogenicity and Therapeutic Activity of AFFITOPE® PD01A in PD-GBA Patients

Who this might be right for
Parkinson's Disease
Affiris AG
Not applicableLooking for participantsNCT05929365
What this trial is testing

Innovative Approach to Detect Recurrent Colorectal Lesions With Surveillance Via Mutation Analysis & Clinical Phenotype

Who this might be right for
Predictive Cancer Model
Military University Hospital, Prague 200
Testing effectiveness (Phase 2)Looking for participantsNCT05485766
What this trial is testing

Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer

Who this might be right for
Triple Negative Breast NeoplasmsTriple Negative Breast CancerBreast Neoplasms+5 more
Okayama University 23
Not applicableStudy completedNCT00582335
What this trial is testing

Identification of New Colorectal Cancer Genes

Who this might be right for
Colorectal Cancer
Memorial Sloan Kettering Cancer Center 337
Not applicableLooking for participantsNCT06089421
What this trial is testing

Genetic Information Assistant in Telegenetics

Who this might be right for
Gene Mutation-Related CancerGenetic Predisposition
University of Virginia 96
Testing effectiveness (Phase 2)Active Not RecruitingNCT03381274
What this trial is testing

Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study

Who this might be right for
Carcinoma, Non-Small-Cell Lung
MedImmune LLC 43
Large-scale testing (Phase 3)Study completedNCT02987543
What this trial is testing

Study of Olaparib (Lynparza™) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer (PROfound Study)

Who this might be right for
Metastatic Castration-resistant Prostate Cancer
AstraZeneca 387
Post-approval studies (Phase 4)UnknownNCT02175914
What this trial is testing

Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis

Who this might be right for
FAP-Familial Adenomatous Polyposis
michal roll 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06976658
What this trial is testing

Glucokinase Activator in Monogenic Diabetes

Who this might be right for
Diabetes MellitusMonogenic Diabetes
Chinese University of Hong Kong 44
Post-approval studies (Phase 4)Study completedNCT05457257
What this trial is testing

Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have BRCA1/2 Mutations

Who this might be right for
Metastatic Castration-resistant Prostate Cancer
AstraZeneca 43
Not applicableUnknownNCT04620980
What this trial is testing

Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease

Who this might be right for
Parkinson Disease
Neuromed IRCCS 600
Testing effectiveness (Phase 2)Ended earlyNCT04161391
What this trial is testing

Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations

Who this might be right for
Non Small Cell Lung CancerMedullary Thyroid CancerRET Gene Mutation+2 more
Turning Point Therapeutics, Inc. 41
Early research (Phase 1)UnknownNCT03827070
What this trial is testing

Dry Pleurodesis With Talcum and Afatinib is Used to Treat Patients With Non-Small Cell Lung Carcinoma

Who this might be right for
Non Small Cell Lung Cancer
Center Trials & Treatment Europe 12
Very early researchStudy completedNCT04901715
What this trial is testing

Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype

Who this might be right for
Primary Ciliary Dyskinesia
University of North Carolina, Chapel Hill 27
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