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Results for “OTOF Gene Mutation”

10 trials

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Showing 10 of 10 results

Very early researchWithdrawnNCT06025032
What this trial is testing

A Study in Subjects With Otoferlin Mutation-related Hearing Loss Using RNA Base-eDiting Therapy(SOUND)

Who this might be right for
Congenital Hearing Loss
HuidaGene Therapeutics Co., Ltd.
Testing effectiveness (Phase 2)Looking for participantsNCT07288580
What this trial is testing

A Clinical Trial of EHT102 Injection in Pediatric Patients With Biallelic hOTOF Mutations

Who this might be right for
Treatment of Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
Shanghai Euhearing Therapeutics Co., Ltd 30
Testing effectiveness (Phase 2)Looking for participantsNCT05788536
What this trial is testing

DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations

Who this might be right for
Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
Regeneron Pharmaceuticals 30
Testing effectiveness (Phase 2)Looking for participantsNCT06370351
What this trial is testing

A Phase I/II Clinical Trial with SENS-501 in Children Suffering from Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations

Who this might be right for
OTOF Gene MutationDFNB9Congenital Deafness+5 more
Sensorion 12
Not applicableWithdrawnNCT06019481
What this trial is testing

A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations

Who this might be right for
Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF)Biallelic Mutations in the Gap Junction Beta 2 (GJB2) GeneDigenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes
Regeneron Pharmaceuticals
Not applicableEnrolling By InvitationNCT06696456
What this trial is testing

Long Term Follow-up Study of AAVAnc80-hOTOF Gene Therapy

Who this might be right for
Otoferlin Gene-mediated Hearing Loss
Akouos, Inc. 30
Not applicableLooking for participantsNCT06722170
What this trial is testing

EH002 Gene Therapy for Otoferlin Gene Mutation-mediated Hearing Loss

Who this might be right for
DFNB9Congenital Hearing LossHearing Loss, Sensorineural
Yilai Shu 24
Not applicableLooking for participantsNCT05402813
What this trial is testing

Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes

Who this might be right for
Sensorineural Hearing Loss, BilateralAUNB1DFNB1A+4 more
Sensorion 180
Testing effectiveness (Phase 2)Looking for participantsNCT05821959
What this trial is testing

Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

Who this might be right for
Sensorineural Hearing Loss, Bilateral
Akouos, Inc. 22
Not applicableUnknownNCT05901480
What this trial is testing

An Investigator Initiated Study for OTOV101N+OTOV101C Injection

Who this might be right for
DFNB9
Otovia Therapeutics 25