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Results for “Optic Atrophy, Hereditary, Leber”

49 trials

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Showing 20 of 49 results

Large-scale testing (Phase 3)WithdrawnNCT01495715
What this trial is testing

Study With Idebenone in Patients With Chronic Vision Loss Due to Leber's Hereditary Optic Neuropathy (LHON)

Who this might be right for
Leber's Hereditary Optic Neuropathy
Santhera Pharmaceuticals
Post-approval studies (Phase 4)Study completedNCT02774005
What this trial is testing

Study to Assess the Efficacy and Safety of Raxone in LHON Patients

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Santhera Pharmaceuticals 199
Large-scale testing (Phase 3)Study completedNCT03406104
What this trial is testing

RESCUE and REVERSE Long-term Follow-up

Who this might be right for
Leber Hereditary Optic Neuropathy
GenSight Biologics 62
Not applicableLooking for participantsNCT02435940
What this trial is testing

Inherited Retinal Degenerative Disease Registry

Who this might be right for
Eye Diseases HereditaryRetinal DiseaseAchromatopsia+25 more
Foundation Fighting Blindness 20,000
Not applicableStudy completedNCT02796274
What this trial is testing

Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic Neuropathy (LHON)

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Santhera Pharmaceuticals 219
Not applicableLooking for participantsNCT01793168
What this trial is testing

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

Who this might be right for
Rare DisordersUndiagnosed DisordersDisorders of Unknown Prevalence+340 more
Sanford Health 20,000
Testing effectiveness (Phase 2)Study completedNCT02693119
What this trial is testing

A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy

Who this might be right for
Leber's Hereditary Optic Neuropathy
Stealth BioTherapeutics Inc. 12
Testing effectiveness (Phase 2)Ended earlyNCT02473445
What this trial is testing

A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease

Who this might be right for
Mitochondrial Diseases
Amgen 22
Early research (Phase 1)Study completedNCT01064505
What this trial is testing

Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients

Who this might be right for
Optic AtrophyNon-arteritic Anterior Ischemic Optic Neuropathy
Quark Pharmaceuticals 48
Not applicableStudy completedNCT04909398
What this trial is testing

Pupil Dynamics and Color Vision for the Detection of Eye Diseases

Who this might be right for
Retinitis PigmentosaLeber's Hereditary Optic NeuropathyStargardt Disease
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts 60
Testing effectiveness (Phase 2)Ended earlyNCT03913130
What this trial is testing

Extension Study to Study PQ-110-001 (NCT03140969)

Who this might be right for
Leber Congenital Amaurosis 10BlindnessLeber Congenital Amaurosis+7 more
Laboratoires Thea 9
Not applicableLooking for participantsNCT06682819
What this trial is testing

Metabolomics Analysis According to the Retinal Nerve Fiber Layer in Patients With NOHL Mutations (MétabOCT)

Who this might be right for
Healthy SubjectsLeber Hereditary Optic Neuropathy
Hôpital Necker-Enfants Malades 90
Not applicableStudy completedNCT05555784
What this trial is testing

Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Argo Sante 12
Large-scale testing (Phase 3)Study completedNCT04561466
What this trial is testing

Trial of Befizal® 200 mg for the Treatment of Leber Hereditary Optic Neuropathy

Who this might be right for
Safety IssuesEfficacy, Self
Hôpital Necker-Enfants Malades 14
Testing effectiveness (Phase 2)Study completedNCT02023866
What this trial is testing

Open-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial Disease

Who this might be right for
Inherited Mitochondrial Disease, Including Leigh Syndrome
Amgen 36
Not applicableStudy completedNCT01892943
What this trial is testing

Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)
Santhera Pharmaceuticals 306
Large-scale testing (Phase 3)Active Not RecruitingNCT07406854
What this trial is testing

A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)
Wuhan Neurophth Biotechnology Limited Company 95
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06792500
What this trial is testing

A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)

Who this might be right for
MELAS SyndromeLebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
George Washington University 24
Testing effectiveness (Phase 2)Study completedNCT03140969
What this trial is testing

Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

Who this might be right for
Leber's Congenital Amaurosis
Laboratoires Thea 11
Not applicableStudy completedNCT03295071
What this trial is testing

REALITY LHON Registry

Who this might be right for
Leber Hereditary Optic Neuropathy
GenSight Biologics 44
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