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Results for “PTEN”

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Showing 20 of 0 results

Early research (Phase 1)Study completedNCT03218826
What this trial is testing

PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

Who this might be right for
Advanced Breast CarcinomaAdvanced Malignant Solid NeoplasmAdvanced Prostate Carcinoma+23 more
National Cancer Institute (NCI) 23
Testing effectiveness (Phase 2)Looking for participantsNCT07109726
What this trial is testing

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

Who this might be right for
Breast CancerEndometrial CancerOvarian Cancer+5 more
Terremoto Biosciences Inc. 205
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06183736
What this trial is testing

CVL237 Tablets in the Treatment of Advanced Solid Tumors With PTEN Deficiency

Who this might be right for
Advanced Solid Tumors
Convalife (Shanghai) Co., Ltd. 98
Early research (Phase 1)Study completedNCT01458067
What this trial is testing

A Phase I/IIa, First Time in Human, Study of GSK2636771 in Subjects With Advanced Solid Tumors With Phosphatase and Tensin Homolog (PTEN) Deficiency

Who this might be right for
Cancer
GlaxoSmithKline 30
Testing effectiveness (Phase 2)Ended earlyNCT04737109
What this trial is testing

Neoadjuvant Androgen Deprivation, Darolutamide, and Ipatasertib in Men With Localized, High Risk Prostate Cancer

Who this might be right for
Castrate Resistant Prostate Cancer
David VanderWeele 6
Not applicableEnded earlyNCT01010256
What this trial is testing

The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia

Who this might be right for
Chronic Myelomonocytic Leukemia
University of Arkansas 4
Testing effectiveness (Phase 2)Study completedNCT01277757
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Advanced Breast Cancer

Who this might be right for
Recurrent Breast CarcinomaStage IIIB Breast CancerStage IIIC Breast Cancer+1 more
National Cancer Institute (NCI) 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439188
What this trial is testing

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 35
Large-scale testing (Phase 3)Ended earlyNCT01633060
What this trial is testing

A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORi

Who this might be right for
Metastatic Breast Cancer
Novartis Pharmaceuticals 432
Not applicableUnknownNCT05111080
What this trial is testing

Partial PTEN Deletion in Breast Cancer

Who this might be right for
PTEN Gene Deletion
Assiut University 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT05810870
What this trial is testing

PIK3CA/PTEN-altered Advanced Breast Cancer Treated With MEN1611 Monotherapy or in Combination With Eribulin

Who this might be right for
Breast CancerAdvanced Breast CancerMetastatic Breast Cancer
MedSIR 14
Testing effectiveness (Phase 2)Study completedNCT03131908
What this trial is testing

Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss

Who this might be right for
Melanoma and Other Malignant Neoplasms of SkinMetastatic Melanoma
M.D. Anderson Cancer Center 28
Testing effectiveness (Phase 2)Study completedNCT00971789
What this trial is testing

Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes

Who this might be right for
Cowden's DiseaseHamartoma Syndrome, Multiple
National Cancer Institute (NCI) 18
Early research (Phase 1)Study completedNCT01226316
What this trial is testing

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

Who this might be right for
Advanced Solid MalignancySafety and TolerabilityPharmacokinetics+11 more
AstraZeneca 285
Testing effectiveness (Phase 2)Study completedNCT00317720
What this trial is testing

Trastuzumab and RAD001 in Patients With Human Epidermal Growth Receptor 2 (HER-2) Overexpressing Breast Cancer

Who this might be right for
Breast CancerNeoplasm Metastasis
M.D. Anderson Cancer Center 40
Not applicableWithdrawnNCT01350180
What this trial is testing

Assessing DNA Changes in High Risk Prostate Cancer to Determine Prognosis

Who this might be right for
Prostate Cancer
Dr. Tamim Niazi
Testing effectiveness (Phase 2)Study completedNCT01276379
What this trial is testing

Study Evaluating Biomarkers in Patients With Colorectal Cancer and Native KRAS Treated With Chemotherapy + Cetuximab

Who this might be right for
Colorectal Cancer
Grupo Espanol Multidisciplinario del Cancer Digestivo 221
Not applicableStudy completedNCT02821728
What this trial is testing

Sulphate Accumulation in Prostate

Who this might be right for
Prostate Cancer
Quadram Institute Bioscience 18
Early research (Phase 1)Study completedNCT01884285
What this trial is testing

AZD8186 First Time In Patient Ascending Dose Study

Who this might be right for
Advanced Castrate-resistant Prostate Cancer CRPCSquamous Non-Small Cell Lung Cancer sqNSCLCTriple Negative Breast Cancer TNBC
AstraZeneca 147
Not applicableStudy completedNCT01796847
What this trial is testing

Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients

Who this might be right for
Critical IllnessHyperglycemia
University of Roma La Sapienza 20
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