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Results for “Paroxysmal Hemoglobinuria, Nocturnal”

190 trials

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Showing 20 of 190 results

Testing effectiveness (Phase 2)Study completedNCT03593200
What this trial is testing

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

Who this might be right for
PNH
Apellis Pharmaceuticals, Inc. 4
Early research (Phase 1)Study completedNCT06294301
What this trial is testing

Single and Multiple Doses of LP-005 in Healthy Adult Participants

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Longbio Pharma 68
Not applicableActive Not RecruitingNCT06633536
What this trial is testing

Real-life Treatment Outcomes of Ravulizumab in PNH

Who this might be right for
Paroxysmal Nocturnal Haemoglobinuria
AstraZeneca 64
Testing effectiveness (Phase 2)Study completedNCT01192399
What this trial is testing

Safety and Efficacy Study of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Patients

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 29
Large-scale testing (Phase 3)Study completedNCT00098280
What this trial is testing

Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Hemoglobinuria, Paroxysmal
National Heart, Lung, and Blood Institute (NHLBI) 75
Not applicableLooking for participantsNCT04645199
What this trial is testing

National Longitudinal Cohort of Hematological Diseases

Who this might be right for
Multiple MyelomaAcute Myeloid LeukemiaHemophilia+14 more
Institute of Hematology & Blood Diseases Hospital, China 2,300
Early research (Phase 1)Study completedNCT05889299
What this trial is testing

Study of the Safety and Efficacy of OMS906 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Omeros Corporation 15
Testing effectiveness (Phase 2)Looking for participantsNCT06745622
What this trial is testing

Long-term Safety and Tolerability of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Haisco Pharmaceutical Group Co., Ltd. 47
Testing effectiveness (Phase 2)Study completedNCT03030183
What this trial is testing

Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients Who Have an Inadequate Response to Eculizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Ra Pharmaceuticals 3
Large-scale testing (Phase 3)Study completedNCT03531255
What this trial is testing

Pegcetacoplan Long Term Safety and Efficacy Extension Study

Who this might be right for
PNH
Apellis Pharmaceuticals, Inc. 137
Early research (Phase 1)Study completedNCT02588833
What this trial is testing

Pilot Study to Assess Safety, Preliminary Efficacy and Pharmacokinetics of S.C. Pegcetacoplan (APL-2) in PNH Subjects.

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Apellis Pharmaceuticals, Inc. 23
Testing effectiveness (Phase 2)Active Not RecruitingNCT06298955
What this trial is testing

Long-Term Safety, Tolerability and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Omeros Corporation 25
Large-scale testing (Phase 3)Study completedNCT03056040
What this trial is testing

ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Alexion Pharmaceuticals, Inc. 202
Testing effectiveness (Phase 2)Study completedNCT01194804
What this trial is testing

E07-001: Safety and Efficacy Extension Study of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Patients

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 27
Not applicableActive Not RecruitingNCT03047746
What this trial is testing

Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF

Who this might be right for
Acquired Aplastic AnemiaParoxysmal Nocturnal HemoglobinuriaInherited Bone Marrow Failure Syndromes
Children's Hospital of Philadelphia 50
Large-scale testing (Phase 3)Active Not RecruitingNCT04434092
What this trial is testing

A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Hoffmann-La Roche 210
Large-scale testing (Phase 3)Study completedNCT04469465
What this trial is testing

Danicopan as Add-on Therapy to a C5 Inhibitor in Paroxysmal Nocturnal Hemoglobinuria (PNH) Participants Who Have Clinically Evident Extravascular Hemolysis (EVH)(ALPHA)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 86
Large-scale testing (Phase 3)Study completedNCT06799546
What this trial is testing

A Phase III Study to Evaluate the Efficacy and Safety of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
PNH
Haisco Pharmaceutical Group Co., Ltd. 73
Testing effectiveness (Phase 2)Looking for participantsNCT07470762
What this trial is testing

Study of Safety and Efficacy of HS-10542 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Jiangsu Hansoh Pharmaceutical Co., Ltd. 50
Not applicableStudy completedNCT04079257
What this trial is testing

The Pharmacokinetics and Pharmacodynamics of Eculizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal HemoglobinuriaEculizumabPK-PD
Radboud University Medical Center 27
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