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Results for “Paroxysmal Hemoglobinuria, Nocturnal”

180 trials

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Showing 20 of 180 results

Large-scale testing (Phase 3)Study completedNCT04058158
What this trial is testing

Compare SB12 (Proposed Eculizumab Biosimilar) to Soliris in Subjects With Paroxysmal Nocturnal Haemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Samsung Bioepis Co., Ltd. 50
Testing effectiveness (Phase 2)Study completedNCT00004464
What this trial is testing

Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Aplastic AnemiaParoxysmal Hemoglobinuria, Nocturnal
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 69
Testing effectiveness (Phase 2)Study completedNCT01194804
What this trial is testing

E07-001: Safety and Efficacy Extension Study of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Patients

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 27
Early research (Phase 1)Study completedNCT05828472
What this trial is testing

Multiple Ascending Doses MY008211A in Healthy Adults

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Wuhan Createrna Science and Technology Co., Ltd 40
Testing effectiveness (Phase 2)Study completedNCT03593200
What this trial is testing

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

Who this might be right for
PNH
Apellis Pharmaceuticals, Inc. 4
Testing effectiveness (Phase 2)Study completedNCT06051357
What this trial is testing

Proof of Concept Study to Assess the Efficacy, Safety of HRS-5965 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Chengdu Suncadia Medicine Co., Ltd. 26
Testing effectiveness (Phase 2)Study completedNCT03946748
What this trial is testing

Study to Evaluate the Efficacy and Safety of REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Regeneron Pharmaceuticals 24
Large-scale testing (Phase 3)Study completedNCT05886244
What this trial is testing

Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) in China

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 25
Testing effectiveness (Phase 2)Study completedNCT01192399
What this trial is testing

Safety and Efficacy Study of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Patients

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 29
Testing effectiveness (Phase 2)Looking for participantsNCT04901936
What this trial is testing

Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)Paroxysmal Hemoglobinuria
Apellis Pharmaceuticals, Inc. 12
Large-scale testing (Phase 3)Looking for participantsNCT06933914
What this trial is testing

Long-term Safety and Tolerability of MY008211A Tablets in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Wuhan Createrna Science and Technology Co., Ltd 120
Large-scale testing (Phase 3)Looking for participantsNCT07154745
What this trial is testing

Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Regeneron Pharmaceuticals 35
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05646563
What this trial is testing

Study of NM8074 in Adult PNH Patients with Inadequate Response to Soliris

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
NovelMed Therapeutics 12
Testing effectiveness (Phase 2)Study completedNCT00004143
What this trial is testing

Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes

Who this might be right for
Sickle Cell AnemiaSevere Aplastic AnemiaParoxysmal Nocturnal Hemoglobinuria (PNH)+1 more
David Rizzieri, MD 2
Post-approval studies (Phase 4)Study completedNCT04320602
What this trial is testing

Ravulizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Currently Treated With High-Dose Eculizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 18
Not applicableApproved For MarketingNCT00438789
What this trial is testing

The Paroxysmal Nocturnal Hemoglobinuria Early Access Treatment Protocol

Who this might be right for
Hemoglobinuria, Paroxysmal
Alexion Pharmaceuticals, Inc.
Not applicableNot Yet RecruitingNCT06848296
What this trial is testing

Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of of VSA012 in Subjects with Paroxysmal Nocturnal Hemoglobinuria(PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Visirna Therapeutics HK Limited 16
Testing effectiveness (Phase 2)Study completedNCT04811716
What this trial is testing

Pozelimab and Cemdisiran Combination Treatment in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab Monotherapy

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Regeneron Pharmaceuticals 24
Large-scale testing (Phase 3)Study completedNCT03406507
What this trial is testing

Ravulizumab (ALXN1210) in Children and Adolescents With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 13
Testing effectiveness (Phase 2)Study completedNCT03439839
What this trial is testing

Study of Safety, Efficacy, Tolerability, Pharmacokinetics and Pharmacodynamics of LNP023 in in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH) With Signs of Active Hemolysis
Novartis Pharmaceuticals 16
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