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Results for “Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia”

80 trials

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Showing 20 of 80 results

Testing effectiveness (Phase 2)Study completedNCT01279473
What this trial is testing

Study to Evaluate Nilotinib in Adult Patients With Imatinib-resistant or Imatinib-intolerant Chronic Myelogenous Leukemia (CML), or Relapse/Refractory Ph+ Acute Lymphoblastic Leukemia (ALL) (Extension Study)

Who this might be right for
Chronic Myelogenous LeukemiaAcute Lymphoblastic Leukemia
Novartis Pharmaceuticals 42
Testing effectiveness (Phase 2)Study completedNCT00109707
What this trial is testing

Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies

Who this might be right for
Chronic Myelogenous LeukemiaAcute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)Hypereosinophilic Syndrome+1 more
Novartis Pharmaceuticals 507
Early research (Phase 1)Study completedNCT01132573
What this trial is testing

Entinostat and Clofarabine in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Poor-Risk Acute Lymphoblastic Leukemia or Bilineage/Biphenotypic Leukemia

Who this might be right for
Acute Leukemias of Ambiguous LineagePhiladelphia Chromosome Negative Adult Precursor Acute Lymphoblastic LeukemiaRecurrent Adult Acute Lymphoblastic Leukemia+1 more
National Cancer Institute (NCI) 27
Testing effectiveness (Phase 2)Active Not RecruitingNCT05456698
What this trial is testing

Efficacy and Safety of Inotuzumab Ozogamicin in Treating Adult Patients With Ph Negative ALL With Minimal Residual Disease Positive After Induction Chemotherapy

Who this might be right for
Acute Lymphocytic Leukemia
Institute of Hematology & Blood Diseases Hospital, China 31
Very early researchStudy completedNCT01184885
What this trial is testing

A Pilot Study to Determine the Safety and Tolerability of Sirolimus Given With Hyper-CVAD Chemotherapy

Who this might be right for
Lymphoid Malignancies (New or Relapsed)Acute Lymphoblastic LeukemiaBurkitt Lymphoma+3 more
Sidney Kimmel Cancer Center at Thomas Jefferson University 7
Testing effectiveness (Phase 2)Study completedNCT00787761
What this trial is testing

Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancer

Who this might be right for
Myeloproliferative DisordersKidney CancerLeukemia+4 more
Northside Hospital, Inc. 24
Large-scale testing (Phase 3)UnknownNCT04375683
What this trial is testing

Study of Efficacy and Safety of Flumatinib Combined With Chemotherapy in Ph Positive ALL

Who this might be right for
Acute Lymphocytic Leukemia, Adult B-CellBCR-ABL1 Fusion Protein Expression
Zhongda Hospital 28
Testing effectiveness (Phase 2)Active Not RecruitingNCT01424982
What this trial is testing

Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia

Who this might be right for
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveAcute Lymphoblastic LeukemiaAdult Acute Lymphoblastic Leukemia in Complete Remission+4 more
M.D. Anderson Cancer Center 88
Large-scale testing (Phase 3)Looking for participantsNCT04994717
What this trial is testing

Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia

Who this might be right for
Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)
Amgen 304
Not applicableLooking for participantsNCT06481241
What this trial is testing

Efficacy and Safety of Chemotherapy Combined With CAR-T Cells in Newly Diagnosed Adult Patients With Ph- B-ALL

Who this might be right for
Philadelphia Chromosome Negative ALLAcute Lymphoblastic Leukemia, Adult
Institute of Hematology & Blood Diseases Hospital, China 77
Large-scale testing (Phase 3)UnknownNCT03564470
What this trial is testing

Precision Diagnosis Directing HDACi and TKI Target Therapy for Adult Ph-like ALL

Who this might be right for
LeukemiaLeukemia, AcuteLeukemia, Lymphoblastic+1 more
Nanfang Hospital, Southern Medical University 120
Testing effectiveness (Phase 2)Active Not RecruitingNCT04475731
What this trial is testing

Ponatinib in Adult Ph+ ALL Patients With MRD Positivity or Hematological Relapse

Who this might be right for
Philadelphia-Positive ALLAcute Lymphoblastic Leukemia, in Relapse
Gruppo Italiano Malattie EMatologiche dell'Adulto 67
Large-scale testing (Phase 3)Active Not RecruitingNCT02003222
What this trial is testing

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

Who this might be right for
Acute Lymphoblastic LeukemiaB Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
National Cancer Institute (NCI) 488
Testing effectiveness (Phase 2)Ended earlyNCT04554459
What this trial is testing

Ponatinib Plus Reduced-intensity Chemotherapy in the First-line Treatment of Adult Patients With Ph+ ALL

Who this might be right for
Acute Lymphoblastic Leukemia, AdultPh+ ALLNewly Diagnosed
Institute of Hematology and Blood Transfusion, Czech Republic 4
Testing effectiveness (Phase 2)Study completedNCT00458848
What this trial is testing

Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia

Who this might be right for
Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto 470
Large-scale testing (Phase 3)Active Not RecruitingNCT04722848
What this trial is testing

Sequential Treatment With Ponatinib and Blinatumomab vs Chemotherapy and Imatinib in Newly Diagnosed Adult Ph+ ALL

Who this might be right for
Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)ALL, AdultPhiladelphia-Positive ALL
Gruppo Italiano Malattie EMatologiche dell'Adulto 236
Testing effectiveness (Phase 2)Looking for participantsNCT06220487
What this trial is testing

A Single-arm, Open-label Study of Olverembatinib, CD3/CD19 Bispecific T-cell Engager, and Chidamide in Patients With Newly Diagnosed Ph+ALL

Who this might be right for
Acute Lymphoblastic LeukemiaPhiladelphia ChromosomePhiladelphia-Positive ALL+2 more
Nanfang Hospital, Southern Medical University 67
Not applicableLooking for participantsNCT06481228
What this trial is testing

Efficacy and Safety of TKI Combined With Chemotherapy and Sequential CAR-T Cells in ND Adult Patients With Ph+ ALL

Who this might be right for
Philadelphia Positive Acute Lymphoblastic LeukemiaAcute Lymphoblastic Leukemia, Adult
Institute of Hematology & Blood Diseases Hospital, China 82
Not applicableNot Yet RecruitingNCT06175702
What this trial is testing

Treatment Protocol for Newky Diagnosed Adult Ph Positive ALL

Who this might be right for
Lymphoblastic LeukemiaPhiladelphia-Positive ALLAdult ALL
PETHEMA Foundation 150
Testing effectiveness (Phase 2)Study completedNCT00495079
What this trial is testing

Safety and Efficacy of Marqibo in Relapsed Acute Lymphoblastic Leukemia

Who this might be right for
Acute Lymphoblastic Leukemia (ALL)
Spectrum Pharmaceuticals, Inc 65
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