Early research (Phase 1)Study completedNCT01918202What this trial is testingEvaluate The PDE10 Enzyme Occupancy Following A Single Dose Of PF-02545920 In Healthy Male VolunteersWho this might be right forHealthy Pfizer 9
Testing effectiveness (Phase 2)Study completedNCT00972569What this trial is testingLow Dose Intravenous (IV) Infusion of BNP in the Presence and Absence of Acute Type V Phosphodiesterase (PDE V) in Improving Renal Function in Hospitalized Chronic Heart Failure (CHF) Patients With Renal DysfunctionWho this might be right forHeart FailureRenal Dysfunction Mayo Clinic 60
Very early researchLooking for participantsNCT06643221What this trial is testingExercise as an Immune Adjuvant for Allogeneic Cell TherapiesWho this might be right forLeukemiaHematopoetic Stem Cell TransplantationDonor Lymphocyte Infusion+3 more University of Arizona 200
Testing effectiveness (Phase 2)UnknownNCT03656666What this trial is testingThe AP-GELP Study: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen PlanusWho this might be right forLichen Planus of VulvaFemale Genital Disease Oslo University Hospital 42
Very early researchStudy completedNCT02061722What this trial is testing[PETDE10] Imaging of PDE10A Enzyme Levels in Huntington's Disease Gene Expansion Carriers and Healthy Controls With PET.Who this might be right forHuntington's Disease CHDI Foundation, Inc. 90
Early research (Phase 1)Study completedNCT00369798What this trial is testingAntidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed PatientsWho this might be right forMajor Depressive DisorderHealthy National Institute of Mental Health (NIMH) 100
Early research (Phase 1)Ended earlyNCT04108377What this trial is testingPhosphodiesterase 4 Inhibitor, Roflumilast, and the Effects of Inhibition in Severe AsthmaWho this might be right forAsthma University of California, Davis 5
Large-scale testing (Phase 3)Study completedNCT00549302What this trial is testingStudy the Safety and Effectiveness of Tadalafil on High Blood Pressure in the Blood Vessel Going From the Heart to the LungsWho this might be right forHypertension, Pulmonary Eli Lilly and Company 357
Early research (Phase 1)Study completedNCT02037074What this trial is testingStudy to Assess the Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) Effects of EVP-6308 and the Potential of EVP-6308 to Affect the PK Properties of the Antipsychotic Regimen in Subjects With Schizophrenia Currently Receiving Stable Treatment With up to 2 Atypical AntipsychoticsWho this might be right forSchizophrenia FORUM Pharmaceuticals Inc 40
Large-scale testing (Phase 3)Study completedNCT01156636What this trial is testingPhosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart FailureWho this might be right forPulmonary HypertensionDiastolic Heart Failure University of Milan 44
Not applicableStudy completedNCT00808912What this trial is testingDoes Sildenafil Increase Exercise Performance in Air Pollution?Who this might be right forPulmonary HypertensionPulmonary Artery PressureExercise Performance+1 more Marywood University 24
Large-scale testing (Phase 3)Ended earlyNCT01910389What this trial is testingPhosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart FailureWho this might be right forHeart FailurePulmonary Hypertension Carelon Research 23
Post-approval studies (Phase 4)Ended earlyNCT00133679What this trial is testingChronic Sildenafil for Severe Diaphragmatic HerniaWho this might be right forHernia, DiaphragmaticHypertension, PulmonaryHypoplasia, Pulmonary University of California, San Francisco 9
Large-scale testing (Phase 3)Study completedNCT01307423What this trial is testingEfficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA)Who this might be right forPsoriatic Arthritis Amgen 529
Early research (Phase 1)Study completedNCT05316428What this trial is testingThe Hemodynamic Interactions of TPN171H Tablets & Alcohol in Healthy Male SubjectsWho this might be right forAlcoholPhosphodiesterase InhibitorErectile Dysfunction Vigonvita Life Sciences 19
Testing effectiveness (Phase 2)Study completedNCT05575505What this trial is testingPhosphodiesterase Inhibitors, Pentoxifylline, as Adjunctive Therapy in Patients With Ulcerative Colitis.Who this might be right forInflammatory Bowel Diseases Tanta University 60
Early research (Phase 1)Active Not RecruitingNCT07428096What this trial is testingPALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's DiseaseWho this might be right forFibrostenotic Crohn's Disease Palisade Bio 6
Testing effectiveness (Phase 2)Study completedNCT01090492What this trial is testingPF-00489791 For The Treatment Of Raynaud'sWho this might be right forRaynaud's DiseasePeripheral Vascular Disease Pfizer 243
Testing effectiveness (Phase 2)Study completedNCT04161456What this trial is testingPreliminary Efficacy and Safety of Apremilast in the Treatment of Acne ConglobataWho this might be right forAcne Conglobata Dr. Frank Behrens 1
Large-scale testing (Phase 3)Study completedNCT01444651What this trial is testingA Trial of Tadalafil and Glycemic TraitsWho this might be right forCardiovascular DiseaseInsulin ResistanceGlucose Intolerance+1 more Thomas J. Wang, MD 73