Testing effectiveness (Phase 2)Looking for participantsNCT07604987What this trial is testingR-PMDT Regimen in Newly Diagnosed PCNSLWho this might be right forPrimary Central Nervous System (CNS) Lymphoma Zou Dehui 33
Early research (Phase 1)Study completedNCT06190678What this trial is testingStudy of Pirtobrutinib (LOXO-305) in Participants With Impaired Kidney Function and Healthy ParticipantsWho this might be right forHealthyRenal Insufficiency Eli Lilly and Company 16
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07122609What this trial is testingPirtobrutinib in Combination With Rituximab, Gemcitabine, Oxaliplatin With or Without Polatuzumab Vedotin in Covalent BTK Inhibitor-Pretreated Relapsed/Refractory Diffuse Large B-Cell LymphomaWho this might be right forRelapsed and Refractory DLBCL Ruijin Hospital 22
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07624799What this trial is testingFixed Duration Treatment With Combined Pirtobrutinib and Short Course Immuno-chemotherapy in Fit Patients With Previously Untreated Symptomatic Chronic Lymphocytic Leukemia (CLL).Who this might be right forCLL (Chronic Lymphocytic Leukemia) French Innovative Leukemia Organisation 82
Not applicableNot Yet RecruitingNCT07525817What this trial is testingA Real-World Study of Pirtobrutinib in cBTKi-Resistant/Intolerant Mature B-Cell LymphomaWho this might be right forMature B-Cell Lymphoma Ou Bai, MD/PHD 40
Testing effectiveness (Phase 2)Looking for participantsNCT07350850What this trial is testingA Multicenter, Prospective Clinical Trial With a Concurrent Control Evaluating Methotrexate Combined With Rituximab,Sintilimab and Pirtobrutinib vs. Investigator-Selected Standard of Care in Treatment-Naive PCNSLWho this might be right forPCNSLPrimary Central Nervous System Lymphoma Tongji Hospital 77
Testing effectiveness (Phase 2)Looking for participantsNCT06948786What this trial is testingPirtobrutinib and Mosunetuzumab for the Treatment of Relapsed/Refractory Grades 1-3A Follicular Lymphoma, PROMOTE-FL TrialWho this might be right forGrade 1 Follicular LymphomaGrade 2 Follicular LymphomaGrade 3a Follicular Lymphoma+2 more University of Washington 22
Testing effectiveness (Phase 2)Looking for participantsNCT06252675What this trial is testingGlofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell LymphomaWho this might be right forMantle Cell Lymphoma University of California, San Francisco 30
Testing effectiveness (Phase 2)WithdrawnNCT06839872What this trial is testingInvestigate the Sequencing Strategy of Pirtobrutinib After Disease Progression on First-line Acalabrutinib Treatment for Adult Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaWho this might be right forChronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma AstraZeneca
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07831395What this trial is testingRituximab, Pirtobrutinib, Lisaftoclax and Liposomal Mitoxantrone for for Richter Syndrome Transformed From CLLWho this might be right forRichter Syndrome Institute of Hematology & Blood Diseases Hospital, China 23
Testing effectiveness (Phase 2)Looking for participantsNCT07231952What this trial is testingPirtobrutinib, Venetoclax, and Rituximab in People With Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)Who this might be right forWaldenstrom MacroglobulinemiaLymphoplasmacytic Lymphoma Memorial Sloan Kettering Cancer Center 40
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07744737What this trial is testingPirtobrutinib + R-CHOP for Untreated Non-GCB DLBCLWho this might be right forDLBCL - Diffuse Large B Cell LymphomaR-CHOP ChemotherapyPirtobrutinib Changzhou No.2 People's Hospital 34
Post-approval studies (Phase 4)Looking for participantsNCT07218341What this trial is testingPirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaWho this might be right forChronic Lymphocytic LeukemiaLymphoma, Small Lymphocytic Eli Lilly and Company 150
Testing effectiveness (Phase 2)Looking for participantsNCT06466122What this trial is testingPirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKiWho this might be right forChronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma Kerry Rogers 30
Not applicableLooking for participantsNCT05643235What this trial is testingImplanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase InhibitorsWho this might be right forAtrial FibrillationSupraventricular ArrhythmiaVentricular Arrhythmias and Cardiac Arrest+2 more Northwell Health 50
Post-approval studies (Phase 4)Looking for participantsNCT06876662What this trial is testing(LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin LymphomaWho this might be right forChronic Lymphocytic LeukemiaNon-Hodgkin Lymphoma Eli Lilly and Company 279
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07684950What this trial is testingLisaftoclax Plus Pirtobrutinib in Relapsed or Refractory Mantle Cell Lymphoma After BTK-Targeted TherapyWho this might be right forMantle Cell Lymphoma (MCL) Henan Cancer Hospital 45
Early research (Phase 1)Study completedNCT06181006What this trial is testingEvaluate Pirtobrutinib (LOXO-305) in Healthy Adult ParticipantsWho this might be right forHealthy Eli Lilly and Company 24
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07622784What this trial is testingPirtobrutinib Maintenance After CAR-T Therapy in Relapsed or Refractory B-Cell LymphomaWho this might be right forRelapsed or Refractory B-cell Lymphoma Sun Yat-sen University 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07744750What this trial is testingPirtobrutinib+Sonrotoclax（PS) Regimen in the Treatment of B-Cell LymphomaWho this might be right forDLBCL - Diffuse Large B Cell LymphomaRichter TransformationCLL / SLL+1 more Changzhou No.2 People's Hospital 40