Not applicableLooking for participantsNCT05394220What this trial is testingMetagenomic Study in Parapneumonic EffusionWho this might be right forParapneumonic Effusion Chinese University of Hong Kong 115
Large-scale testing (Phase 3)Looking for participantsNCT05766124What this trial is testingTrial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE)Who this might be right forPleural Infection Chinese University of Hong Kong 30
Post-approval studies (Phase 4)Looking for participantsNCT07095361What this trial is testingOnce Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or EmpyemaWho this might be right forPleural Infection BacterialPleural InfectionsPleural Infections and Inflammations+5 more University of North Carolina, Chapel Hill 270
Post-approval studies (Phase 4)Study completedNCT03873766What this trial is testingManagement of Pleural Space InfectionsWho this might be right forEmpyema, PleuralParapneumonic Effusion Swedish Medical Center 26
Not applicableLooking for participantsNCT06434324What this trial is testingPleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic EffusionWho this might be right forPleural Infection Mayo Clinic 60
Not applicableNot Yet RecruitingNCT07077096What this trial is testingDiagnostic Utility of Pleural Infection-specific Multiplex PCR PanelWho this might be right forPleural Infection Chinese University of Hong Kong 800
Not applicableStudy completedNCT03583931What this trial is testingTreatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs DecorticationWho this might be right forParapneumonic EffusionEmpyema, PleuralCoagulopathy Denver Health and Hospital Authority 10
Large-scale testing (Phase 3)Study completedNCT00202826What this trial is testingStudy of Fluid Collection of the Chest in Children With PneumoniaWho this might be right forCommunity Acquired Bacterial PneumoniaParaneumonic Effusion Corewell Health West 30
Not applicableUnknownNCT00103766What this trial is testingAlteplase for Treatment of Empyema and Complicated Parapneumonic EffusionWho this might be right forEmpyemaPleural Effusion O'Brien, Jeana D., MD, FACP, FCCP 75
Not applicableNot Yet RecruitingNCT07188714What this trial is testingVideo-assisted Thoracoscopic Surgery (VATS) Has Revolutionised Management of Complicated PPE, Our Study to Determine VATS Decortication Technique is Needed, Compared to VATS Debridement in PPE, Also RAPID Score and Pleural US Parameters Can Predict Which VATS Procedure is Needed.Who this might be right forParapneumonic Effussion Assiut University 95
Not applicableStudy completedNCT04477980What this trial is testingRetrospective Review on Patients With Culture Negative EmpyemaWho this might be right forEmpyema, Pleural Chinese University of Hong Kong 153
Not applicableStudy completedNCT00468104What this trial is testingEfficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/EmpyemasWho this might be right forPleural Effusion Associated With Pulmonary InfectionBacterial Pleural Effusion Other Than Tuberculosis Midwest Pulmonary and Critical Care 100
Large-scale testing (Phase 3)Ended earlyNCT00234208What this trial is testingEarly Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural EmpyemaWho this might be right forComplicated Parapneumonic EffusionPleural Empyema University Hospital, Basel, Switzerland 2
Post-approval studies (Phase 4)Not Yet RecruitingNCT07592520What this trial is testingFlush, Lyse, OperateWho this might be right forComplicated Parapneumonic EffusionEmpyema, Pleural Dartmouth-Hitchcock Medical Center 30
Post-approval studies (Phase 4)Study completedNCT03468933What this trial is testingFibrinolysis Compared to Thoracoscopy for Pleural InfectionWho this might be right forPleural InfectionEmpyemaPleural Diseases+1 more Tulane University 32
Post-approval studies (Phase 4)Study completedNCT01246453What this trial is testingEfficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and EmpyemaWho this might be right forEmpyema, PleuralPleural EffusionPleural Diseases Hospital Universitari Vall d'Hebron Research Institute 204
Testing effectiveness (Phase 2)Looking for participantsNCT06713382What this trial is testingEvaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]Who this might be right forPleural Effusion Associated With Pulmonary InfectionPleural Effusion DisorderPleural Effusions Beth Israel Deaconess Medical Center 96