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Results for “Primary Hemophagocytic Lymphohistiocytosis”

31 trials

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Showing 20 of 31 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT06736080
What this trial is testing

Safety and Efficacy of Gene Therapy of FHL Type 3 Caused by Mutations in the Human UNC13D Gene by Transplantation of a Single Dose of Autologous CD34+ Cells Transduced ex Vivo With the UNC13D LV Vector Expressing the UNC13D cDNA

Who this might be right for
Familial Hemophagocytic Lymphohistiocytosis Type 3 (FHL 3)
Assistance Publique - Hôpitaux de Paris 5
Not applicableEnded earlyNCT00006054
What this trial is testing

Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies

Who this might be right for
Immunologic Deficiency SyndromesChediak-Higashi SyndromeCommon Variable Immunodeficiency+11 more
Fairview University Medical Center
Early research (Phase 1)Active Not RecruitingNCT01494103
What this trial is testing

Administration of Donor T Cells With the Caspase-9 Suicide Gene

Who this might be right for
Acute Lymphoblastic LeukemiaMyelodysplastic SyndromeAcute Myeloid Leukemia+7 more
Baylor College of Medicine 15
Not applicableActive Not RecruitingNCT05236764
What this trial is testing

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Who this might be right for
Acute Lymphoblastic Leukemia in RemissionAcute Myeloid Leukemia in RemissionMyelodysplastic Syndromes+8 more
Baylor College of Medicine 3
Not applicableUnknownNCT00006056
What this trial is testing

Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders

Who this might be right for
Chediak-Higashi SyndromeGraft Versus Host DiseaseX-Linked Lymphoproliferative Syndrome+3 more
Fairview University Medical Center 40
Not applicableStudy completedNCT05687474
What this trial is testing

Baby Detect : Genomic Newborn Screening

Who this might be right for
Congenital Adrenal HyperplasiaFamilial Hyperinsulinemic Hypoglycemia 1Phosphoglucomutase 1 Deficiency+121 more
Centre Hospitalier Universitaire de Liege 6,824
Testing effectiveness (Phase 2)Study completedNCT01998633
What this trial is testing

Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)

Who this might be right for
Hemophagocytic LymphohistiocytosisChronic Active Epstein-Barr Virus InfectionChronic Granulomatous Disease+3 more
Medical College of Wisconsin 47
Not applicableNot Yet RecruitingNCT07741747
What this trial is testing

Impact of Ultra-fast Genetic Diagnosis of Familial Lymphohistiocytosis on the Time to Bone Marrow Transplantation and Overall Survival

Who this might be right for
Familial LymphohistiocytosisLymphohistiocytosis
Assistance Publique Hopitaux De Marseille 240
Testing effectiveness (Phase 2)Study completedNCT00368355
What this trial is testing

T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts

Who this might be right for
Acute Lymphoblastic LeukemiaNon Hodgkins LymphomaMyelodysplastic Syndrome+6 more
Baylor College of Medicine 46
Early research (Phase 1)Active Not RecruitingNCT00710892
What this trial is testing

CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene

Who this might be right for
Acute Lymphoblastic LeukemiaNon-Hodgkin's LymphomaMyelodysplastic Syndrome+1 more
Baylor College of Medicine 10
Early research (Phase 1)Ended earlyNCT02231710
What this trial is testing

Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases

Who this might be right for
Primary Immune Deficiency DisordersHemophagocytic LymphohistiocytosisInherited Bone Marrow Failure Syndrome+2 more
Bellicum Pharmaceuticals 1
Testing effectiveness (Phase 2)Study completedNCT03513328
What this trial is testing

Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

Who this might be right for
Bone Marrow Failure SyndromeThalassemiaSickle Cell Disease+13 more
University of Florida 6
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07660783
What this trial is testing

Naive T Cell Deplete Grafts for GVHD Prevention in Non-Malignant Diseases

Who this might be right for
Bone Marrow FailureHemoglobinopathiesPrimary Immune Deficiency (PID)+4 more
Fred Hutchinson Cancer Center 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT01821781
What this trial is testing

Immune Disorder HSCT Protocol

Who this might be right for
Immune Deficiency DisordersSevere Combined ImmunodeficiencyChronic Granulomatous Disease+11 more
Washington University School of Medicine 20
Post-approval studies (Phase 4)Study completedNCT05744063
What this trial is testing

A Post-authorization Study to Describe the Safety and Efficacy of Emapalumab for the Treatment of pHLH in Treatment Experienced Chinese Patients

Who this might be right for
Primary Hemophagocytic Lymphohistiocytosis
Swedish Orphan Biovitrum 13
Not applicableUnknownNCT06587191
What this trial is testing

Emapalumab Efficacy in Children With Primary Hemophagocytic Lymphohistiocytosis

Who this might be right for
Primary Hemophagocytic Lymphohistiocytosis
Federal Research Institute of Pediatric Hematology, Oncology and Immunology 7
Large-scale testing (Phase 3)Study completedNCT03312751
What this trial is testing

Study to Assess the Efficacy and Safety of Emapalumab in Primary Haemophagocytic Lymphohistiocytosis

Who this might be right for
Primary Hemophagocytic Lymphohistiocytosis
Swedish Orphan Biovitrum 35
Not applicableActive Not RecruitingNCT01652092
What this trial is testing

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

Who this might be right for
SCIDOmenn's SyndromeReticular Dysgenesis+11 more
Masonic Cancer Center, University of Minnesota 57
Testing effectiveness (Phase 2)Study completedNCT00176865
What this trial is testing

Stem Cell Transplant for Immunologic or Histiocytic Disorders

Who this might be right for
Hemophagocytic LymphohistiocytosisX-Linked Lymphoproliferative DisordersChediak-Higashi Syndrome+3 more
Masonic Cancer Center, University of Minnesota 19
Not applicableStudy completedNCT04902807
What this trial is testing

Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation

Who this might be right for
Autoimmune Lymphoproliferative SyndromeAutoimmune CytopeniaAutoimmune Diseases+17 more
Institut National de la Santé Et de la Recherche Médicale, France 325
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