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Results for “Primary Mitochondrial Diseases”

57 trials

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Showing 20 of 57 results

Testing effectiveness (Phase 2)Ended earlyNCT02976038
What this trial is testing

Open-Label Extension Trial to Characterize the Long-term Safety and Tolerability of Elamipretide in Subjects With Genetically Confirmed Primary Mitochondrial Myopathy (PMM)

Who this might be right for
Primary Mitochondrial Disease
Stealth BioTherapeutics Inc. 28
Testing effectiveness (Phase 2)Study completedNCT02805790
What this trial is testing

Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER Study

Who this might be right for
Primary Mitochondrial Disease
Stealth BioTherapeutics Inc. 30
Not applicableStudy completedNCT02920671
What this trial is testing

Muscle OXPHOS and Nutrient Homeostasis

Who this might be right for
Mitochondrial DiseasesObesity
University of Pennsylvania 45
Not applicableStudy completedNCT00626847
What this trial is testing

How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

Who this might be right for
Primary Open Angle Glaucoma
Wills Eye 97
Large-scale testing (Phase 3)Study completedNCT05162768
What this trial is testing

Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)

Who this might be right for
Mitochondrial MyopathiesMitochondrial PathologyMitochondrial DNA Mutation+5 more
Stealth BioTherapeutics Inc. 102
Post-approval studies (Phase 4)UnknownNCT05411978
What this trial is testing

Safety and Efficacy of Oral Idebenone for Preventive Treatment of Migraine in Adult Migraine Patients

Who this might be right for
Migraine
Beijing Tiantan Hospital 900
Not applicableLooking for participantsNCT04602325
What this trial is testing

Systemic Biomarkers of Brain Injury From Hyperammonemia

Who this might be right for
Urea Cycle DisorderOrganic AcidemiaMaple Syrup Urine Disease+3 more
Children's National Research Institute 24
Testing effectiveness (Phase 2)Study completedNCT04513002
What this trial is testing

Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis

Who this might be right for
Ataxia Telangiectasia
The University of Queensland 30
Not applicableEnrolling By InvitationNCT04734626
What this trial is testing

CrCest Study in Primary Mitochondrial Disease

Who this might be right for
Mitochondrial Diseases
Children's Hospital of Philadelphia 230
Not applicableLooking for participantsNCT06167135
What this trial is testing

Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort

Who this might be right for
Infertility, FemalePolycystic Ovary SyndromeInsulin Resistance+3 more
Semmelweis University 150
Testing effectiveness (Phase 2)Looking for participantsNCT06754098
What this trial is testing

Doxecitin and Doxribthymine in Adult Subjects With Thymidine Kinase 2 (TK2) Deficiency

Who this might be right for
Thymidine Kinase 2 (TK2 ) DeficiencyMitochondrial Myopathies
Cristina Domínguez González 15
Testing effectiveness (Phase 2)Ended earlyNCT04641962
What this trial is testing

Evaluate ASP0367 in Participants With Primary Mitochondrial Myopathy

Who this might be right for
Primary Mitochondrial Myopathy
Astellas Pharma Inc 34
Not applicableStudy completedNCT05687474
What this trial is testing

Baby Detect : Genomic Newborn Screening

Who this might be right for
Congenital Adrenal HyperplasiaFamilial Hyperinsulinemic Hypoglycemia 1Phosphoglucomutase 1 Deficiency+121 more
Centre Hospitalier Universitaire de Liege 6,824
Not applicableUnknownNCT01298375
What this trial is testing

Metabolic Phenotyping in Humans

Who this might be right for
HealthyObesityType 2 Diabetes Mellitus
Maastricht University Medical Center 132
Not applicableStudy completedNCT00727974
What this trial is testing

Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines

Who this might be right for
VomitingMigraines
Medical College of Wisconsin 586
Large-scale testing (Phase 3)Looking for participantsNCT06451757
What this trial is testing

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

Who this might be right for
Mitochondrial DiseasesMaternally Inherited Diabetes and Deafness (MIDD)Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)+1 more
Khondrion BV 220
Early research (Phase 1)Study completedNCT00001328
What this trial is testing

Gene Therapy for the Treatment of Brain Tumors

Who this might be right for
Brain NeoplasmNeoplasm Metastasis
National Institute of Neurological Disorders and Stroke (NINDS) 15
Testing effectiveness (Phase 2)Looking for participantsNCT06792500
What this trial is testing

A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)

Who this might be right for
MELAS SyndromeLebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
George Washington University 24
Not applicableStudy completedNCT03120013
What this trial is testing

Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia

Who this might be right for
Ataxia, CerebellarCerebellar AtaxiaSpinocerebellar Ataxias+8 more
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 21
Not applicableLooking for participantsNCT06890520
What this trial is testing

Neurometabolic Profile of Individuals With Primary Mitochondrial Disease

Who this might be right for
Primary Mitochondrial Disease
Children's Hospital of Philadelphia 30
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