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Results for “Programmed Cell Death 1 Inhibitor”

72 trials

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Showing 20 of 72 results

Large-scale testing (Phase 3)Ended earlyNCT04246177
What this trial is testing

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Who this might be right for
Carcinoma, Hepatocellular
Merck Sharp & Dohme LLC 480
Large-scale testing (Phase 3)Study completedNCT03713593
What this trial is testing

Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib as First-line Therapy in Participants With Advanced Hepatocellular Carcinoma (MK-7902-002/E7080-G000-311/LEAP-002)

Who this might be right for
Carcinoma, Hepatocellular
Merck Sharp & Dohme LLC 794
Not applicableUnknownNCT04922541
What this trial is testing

Multi-center Observational Study on the Progression of Atherosclerotic Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up

Who this might be right for
Plaque, AtheroscleroticProgrammed Cell Death Protein 1 Inhibitor
Second Affiliated Hospital, Zhejiang University, School of Medicine 50
Early research (Phase 1)WithdrawnNCT03920839
What this trial is testing

INCMGA00012 Plus Chemotherapy in Participants With Advanced Solid Tumors (POD1UM-105)

Who this might be right for
Advanced and/or Metastatic Solid TumorsStage IIIB Not Amenable to Curative Therapy to Stage IV Non-small Cell Lung CancerAdvanced/Metastatic Unresectable Malignant Pleural Mesothelioma
Incyte Corporation
Testing effectiveness (Phase 2)Active Not RecruitingNCT06644768
What this trial is testing

Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations

Who this might be right for
Non-small Cell Lung CancerLung Cancer
Daiichi Sankyo 137
Large-scale testing (Phase 3)Study completedNCT03260894
What this trial is testing

Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302)

Who this might be right for
Renal Cell Carcinoma (RCC)
Incyte Corporation 129
Large-scale testing (Phase 3)WithdrawnNCT03342352
What this trial is testing

Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310)

Who this might be right for
Head and Neck Cancer
Incyte Corporation
Early research (Phase 1)Ended earlyNCT04458259
What this trial is testing

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

Who this might be right for
Neoplasm Metastasis
Pfizer 88
Early research (Phase 1)Looking for participantsNCT05142189
What this trial is testing

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
BioNTech SE 320
Testing effectiveness (Phase 2)Study completedNCT00768651
What this trial is testing

Incretin Effect and Use After Clinical Islet Transplantation

Who this might be right for
Type 1 Diabetes
University of Alberta 8
Testing effectiveness (Phase 2)Active Not RecruitingNCT05565378
What this trial is testing

A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer

Who this might be right for
Lung Cancer, Non-Small Cell
GlaxoSmithKline 351
Testing effectiveness (Phase 2)Study completedNCT02466516
What this trial is testing

Safety, Tolerability, and Efficacy of GS-4997 Alone or in Combination With Simtuzumab (SIM) in Adults With Nonalcoholic Steatohepatitis (NASH) and Fibrosis Stages F2-F3

Who this might be right for
Non-Alcoholic Steatohepatitis (NASH)
Gilead Sciences 72
Early research (Phase 1)Ended earlyNCT04155580
What this trial is testing

ASTX660 as a Single Agent and in Combination With ASTX727 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Who this might be right for
Acute Myeloid Leukemia
Astex Pharmaceuticals, Inc. 68
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06142617
What this trial is testing

A Prospective Study of Pembrolizumab Combining Chemotherapy in Advanced NSCLC Patients With EGFR Exon 21 Point Mutation.

Who this might be right for
Non Small Cell Lung CancerImmune Checkpoint InhibitorEGFR Exon 21 Mutation
Peking Union Medical College Hospital 37
Early research (Phase 1)Ended earlyNCT05375084
What this trial is testing

SHP2 Inhibitor BBP-398 in Combination With Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer With a KRAS Mutation

Who this might be right for
Non Small Cell Lung CancerSolid Tumor
Navire Pharma Inc., a BridgeBio company 21
Testing effectiveness (Phase 2)Ended earlyNCT00768339
What this trial is testing

A Phase 1-2, Multicenter, Open-Label Study of AEG35156 in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia and Indolent B-Cell Lymphomas

Who this might be right for
Leukemia, Lymphocytic, Chronic, B-CellLymphoma, B-Cell
Aegera Therapeutics 25
Testing effectiveness (Phase 2)Active Not RecruitingNCT05975307
What this trial is testing

Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation

Who this might be right for
Muscle-Invasive Bladder CarcinomaProgrammed Cell Death Protein 1 InhibitorRadiotherapy
Sun Yat-sen University 71
Testing effectiveness (Phase 2)Study completedNCT03322566
What this trial is testing

Pembrolizumab Plus Epacadostat With Platinum-based Chemotherapy Versus Pembrolizumab Plus Platinum-based Chemotherapy Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-715-06/ECHO-306-06)

Who this might be right for
Lung Cancer
Incyte Corporation 233
Early research (Phase 1)Study completedNCT04393506
What this trial is testing

Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma

Who this might be right for
Oral CancerVEGFR2 InhibitorProgrammed Cell Death 1 Inhibitor+1 more
Shanghai Jiao Tong University School of Medicine 21
Large-scale testing (Phase 3)WithdrawnNCT06513884
What this trial is testing

HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer

Who this might be right for
Oropharyngeal Squamous Cell Carcinoma Recurrent
Hookipa Biotech GmbH
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