Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency”

103 trials

Showing 20 of 103 results

Large-scale testing (Phase 3)Looking for participantsNCT06165341
What this trial is testing

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

Who this might be right for
Alpha1-Antitrypsin Deficiency
Takeda 50
Large-scale testing (Phase 3)Active Not RecruitingNCT01983241
What this trial is testing

Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)

Who this might be right for
Pulmonary Emphysema in Alpha-1 PI Deficiency
Grifols Therapeutics LLC 345
Testing effectiveness (Phase 2)WithdrawnNCT01183455
What this trial is testing

A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part II

Who this might be right for
Diabetes Mellitus, Type 1
National Institute of Allergy and Infectious Diseases (NIAID)
Testing effectiveness (Phase 2)Study completedNCT03945292
What this trial is testing

Safety, Tolerability and Pharmacodynamic Effect of Fazirsiran (TAK-999, ARO-AAT)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Arrowhead Pharmaceuticals 40
Early research (Phase 1)Study completedNCT05727800
What this trial is testing

A Phase 1, First-in-human Study of VX-668

Who this might be right for
Alpha-1 Antitrypsin Deficiency
Vertex Pharmaceuticals Incorporated 114
Testing effectiveness (Phase 2)Study completedNCT02947087
What this trial is testing

Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis

Who this might be right for
Chronic Pancreatitis
Medical University of South Carolina 48
Large-scale testing (Phase 3)Active Not RecruitingNCT05899673
What this trial is testing

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Who this might be right for
Alpha1-Antitrypsin Deficiency
Takeda 31
Testing effectiveness (Phase 2)WithdrawnNCT03385395
What this trial is testing

Study Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin Deficiency

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Octapharma
Post-approval studies (Phase 4)Study completedNCT00396006
What this trial is testing

Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Baxalta now part of Shire 21
Testing effectiveness (Phase 2)Looking for participantsNCT06389877
What this trial is testing

Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Beam Therapeutics Inc. 106
Post-approval studies (Phase 4)Study completedNCT01651351
What this trial is testing

GLASSIA Infusion Rate Study

Who this might be right for
Alpha1-antitrypsin DeficiencyHealthy Volunteers
Baxalta now part of Shire 30
Not applicableUnknownNCT04966221
What this trial is testing

Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease

Who this might be right for
Chronic Obstructive Pulmonary DiseaseAlpha 1-Antitrypsin Deficiency
University of Nottingham 75
Not applicableWithdrawnNCT02273349
What this trial is testing

Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency

Who this might be right for
Alpha-1-Antitrypsin DeficiencyChronic Obstructive Lung DiseaseEmphysema
University Hospital, Saarland
Testing effectiveness (Phase 2)WithdrawnNCT05146882
What this trial is testing

An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATLD)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Testing effectiveness (Phase 2)Active Not RecruitingNCT05897424
What this trial is testing

Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema

Who this might be right for
Alpha 1-Antitrypsin DeficiencyEmphysema
Sanofi 185
Testing effectiveness (Phase 2)Study completedNCT05856331
What this trial is testing

Study of SAR447537 (INBRX-101) Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema

Who this might be right for
Alpha 1-Antitrypsin DeficiencyEmphysema
Sanofi 99
Not applicableStudy completedNCT03383939
What this trial is testing

Inhaled A1AT in Adult Stable Bronchiectasis

Who this might be right for
Bronchiectasis Adult
Hospital Universitari Vall d'Hebron Research Institute 20
Testing effectiveness (Phase 2)Study completedNCT03636347
What this trial is testing

A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.

Who this might be right for
Alpha 1-Antitrypsin DeficiencyEmphysemaCOPD
Mereo BioPharma 99
Early research (Phase 1)Looking for participantsNCT06738017
What this trial is testing

Study of BMN 349 Single Dose in PiZZ and PiMZ/MASH Adult Participants

Who this might be right for
Alpha 1-Antitrypsin Deficiency
BioMarin Pharmaceutical 12
Early research (Phase 1)Ended earlyNCT01183468
What this trial is testing

A Research Trial of Aralast in New Onset Diabetes (RETAIN)

Who this might be right for
Diabetes Mellitus, Type 1
National Institute of Allergy and Infectious Diseases (NIAID) 17
Load More Results

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation