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Results for “RAS Family Gene Mutation”

59 trials

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Showing 20 of 59 results

Not applicableLooking for participantsNCT04151342
What this trial is testing

CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)

Who this might be right for
CancerMalignancies MultipleMalignant Solid Tumor+7 more
University Health Network, Toronto 5,500
Testing effectiveness (Phase 2)Study completedNCT00655161
What this trial is testing

A Pilot Phase 2 Trial of the Immunogenicity, and Safety of GI-4000; an Inactivated Recombinant S. Cerevisiae Expressing Mutant Ras Protein, as Consolidation Therapy Following Curative Treatment for Stage I-III Non-Small Cell Lung Cancer (NSCLC) With Tumor Sequence Confirmation of K-ras Mutation

Who this might be right for
NSCLC
GlobeImmune 24
Testing effectiveness (Phase 2)Enrolling By InvitationNCT06936527
What this trial is testing

XS-03 in Combination With FOLFOX or FOLFIRI and Bevacizumab for Treatment of Metastatic Colorectal Cancer Patients With RAS Mutation

Who this might be right for
Colorectal CancerMetastatic Colorectal Cancer With RAS Mutation
NovaOnco Therapeutics Co., Ltd. 102
Early research (Phase 1)WithdrawnNCT00837135
What this trial is testing

GI-4000 With Adoptive Transfer in Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
University of Pennsylvania
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07678593
What this trial is testing

GFH276 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors and Pancreatic Ductal Adenocarcinoma (PDAC) Harboring RAS Mutation

Who this might be right for
Advanced Solid Tumors CancerPancreatic Ductal AdenocarcinomaRAS Mutation
Genfleet Therapeutics (Shanghai) Inc. 222
Testing effectiveness (Phase 2)UnknownNCT05640726
What this trial is testing

The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy

Who this might be right for
Rectal Cancer
Fujian Cancer Hospital 30
Early research (Phase 1)Ended earlyNCT05831995
What this trial is testing

Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

Who this might be right for
Advanced Solid TumorRAS MutationRAF Mutation+1 more
ABM Therapeutics Corporation 12
Early research (Phase 1)Not Yet RecruitingNCT07686445
What this trial is testing

AN4035 in Advanced Cancers With RAS Mutations and High CEACAM5 Expression

Who this might be right for
Solid Tumor (Phase I)RAS MutationCEACAM5
Adlai Nortye Biopharma Co., Ltd. 228
Early research (Phase 1)Looking for participantsNCT06299839
What this trial is testing

PAS-004 in Patients With Advanced Solid Tumors

Who this might be right for
RAS MutationNF1 MutationRAF Mutation+1 more
Pasithea Therapeutics Corp. 48
Not applicableUnknownNCT02502656
What this trial is testing

RAS Mutation Testing in the Circulating Blood of Patients With Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Association des Gastroentérologues Oncologues 425
Testing effectiveness (Phase 2)Temporarily pausedNCT05756556
What this trial is testing

T3011 in Combination With Cobimetinib in Patients With Advanced Melanoma

Who this might be right for
MelanomaMalignant Melanoma
ImmVira Pharma Co. Ltd 68
Testing effectiveness (Phase 2)Looking for participantsNCT05727163
What this trial is testing

FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients

Who this might be right for
Colorectal Cancer Metastatic
Sun Yat-sen University 194
Testing effectiveness (Phase 2)Looking for participantsNCT06218810
What this trial is testing

Cadonilimab in Combination With Bevacizumab and FOLFOX Regimen for the First-Line Treatment of Advanced Unresectable MSS-Type, RAS-Mutated Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal CancerMicrosatellite Stable Colorectal CarcinomaRAS Mutation+1 more
Fudan University 53
Testing effectiveness (Phase 2)Study completedNCT05340621
What this trial is testing

NAUTILUS: OKI-179 Plus Binimetinib in Patients with Advanced Solid Tumors in the RAS Pathway (Phase 1b) and NRAS-mutated Melanoma (Phase 2)

Who this might be right for
RAS MutationNRAS Gene MutationMelanoma
OnKure, Inc. 36
Testing effectiveness (Phase 2)Study completedNCT02448290
What this trial is testing

Single-arm Study of Selumetinib in Combination With Docetaxel, in Advanced Gastric Adenocarcinoma Patients With Low/High MEK Signature, RAS Mutation or RAS Amplification as a Second-line Chemotherapy

Who this might be right for
Gastric Adenocarcinoma
Samsung Medical Center 25
Testing effectiveness (Phase 2)Study completedNCT01298570
What this trial is testing

Regorafenib+FOLFIRI Versus Placebo+FOLFIRI as 2nd Line Tx in Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
UNC Lineberger Comprehensive Cancer Center 181
Testing effectiveness (Phase 2)Looking for participantsNCT07213570
What this trial is testing

STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
National Cancer Institute, Naples 60
Not applicableLooking for participantsNCT04395495
What this trial is testing

RASopathy Biorepository

Who this might be right for
RAS MutationNeurofibromatosis 1Noonan Syndrome+11 more
Children's Hospital Medical Center, Cincinnati 1,000
Early research (Phase 1)Looking for participantsNCT04678648
What this trial is testing

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

Who this might be right for
Advanced Malignant Solid NeoplasmRAS MutationLung Cancer+3 more
RasCal Therapeutics, Inc. 134
Early research (Phase 1)Looking for participantsNCT06884618
What this trial is testing

Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

Who this might be right for
Neoplasms
Hoffmann-La Roche 405
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