Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)”

46 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 46 results

Testing effectiveness (Phase 2)Looking for participantsNCT06597565
What this trial is testing

A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCC

Who this might be right for
Head and Neck Squamous Cell Carcinoma
H. Lee Moffitt Cancer Center and Research Institute 43
Testing effectiveness (Phase 2)Study completedNCT01040832
What this trial is testing

EMD 1201081 in Combination With Cetuximab in Second-Line Cetuximab-Naïve Subjects With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Who this might be right for
Squamous Cell Carcinoma of the Head and Neck Cancer
EMD Serono 107
Testing effectiveness (Phase 2)Looking for participantsNCT06052839
What this trial is testing

Pulsed Dose Chemotherapy Plus Pembrolizumab in Recurrent/Metastatic HNSCC

Who this might be right for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)
Dan Zandberg 15
Testing effectiveness (Phase 2)Study completedNCT04997902
What this trial is testing

Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Who this might be right for
HNSCC
Kura Oncology, Inc. 45
Testing effectiveness (Phase 2)Looking for participantsNCT04857164
What this trial is testing

Study of Pembrolizumab Combined with Chemotherapy in the First Line Therapy for R/M HNSCC in China

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Yuankai Shi 150
Testing effectiveness (Phase 2)Study completedNCT04282109
What this trial is testing

Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)

Who this might be right for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Grupo Español de Tratamiento de Tumores de Cabeza y Cuello 141
Testing effectiveness (Phase 2)Looking for participantsNCT06935188
What this trial is testing

Dalpicilib Plus Cetuximab Compared With Cetuximab Alone in HPV-negative, Anti-PD-1-resistant R/M HNSCC

Who this might be right for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University 98
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07662720
What this trial is testing

A Phase II Trial for MOR Antagonism With Axelopran to Enhance Immunotherapy in Head and Neck Cancer

Who this might be right for
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M)
Glycyx Therapeutics 18
Not applicableStudy completedNCT05123950
What this trial is testing

Treatment Patterns and Clinical Outcomes in First Line Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (1L R/M SCCHN) Participants in Europe

Who this might be right for
Squamous Cell Carcinoma of the Head and Neck
Bristol-Myers Squibb 304
Not applicableUnknownNCT04740996
What this trial is testing

Study of Pembrolizumab in the First Line Therapy for R/M HNSCC in China

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Shi Yuankai 30
Testing effectiveness (Phase 2)Looking for participantsNCT07398664
What this trial is testing

H101 Plus TACE for r/m HNSCC

Who this might be right for
Head and Neck Squamous Cell CarcinomaOncolytic VirusTACE
West China Hospital 20
Large-scale testing (Phase 3)Not Yet RecruitingNCT06719479
What this trial is testing

A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.).

Who this might be right for
NPCHNSCCRecurrence+1 more
SUNHO(China)BioPharmaceutical CO., Ltd. 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07354984
What this trial is testing

A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Who this might be right for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Sun Yat-sen University 30
Testing effectiveness (Phase 2)UnknownNCT04882462
What this trial is testing

Sintilimab and Nimotuzumab Combined With Chemotherapy for the Treatment of R/M HNSCC.

Who this might be right for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
The First Affiliated Hospital of Soochow University 100
Testing effectiveness (Phase 2)Ended earlyNCT02822482
What this trial is testing

Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss

Who this might be right for
Carcinoma, Squamous Cell of Head and Neck
UNICANCER 11
Testing effectiveness (Phase 2)Study completedNCT02718820
What this trial is testing

Pembrolizumab Plus Docetaxel for the Treatment of Recurrent or Metastatic Head and Neck Cancer

Who this might be right for
Head and Neck Carcinoma
Medical University of Vienna 22
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07659678
What this trial is testing

CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma

Who this might be right for
Head and Neck Squamous Cell CarcinomaHead and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M)Head and Neck Squamous Cell Carcinoma HNSCC
Washington University School of Medicine 90
Testing effectiveness (Phase 2)UnknownNCT03088059
What this trial is testing

Biomarker-based Study in R/M SCCHN

Who this might be right for
Carcinoma, Squamous Cell of Head and Neck
European Organisation for Research and Treatment of Cancer - EORTC 340
Testing effectiveness (Phase 2)Looking for participantsNCT07807163
What this trial is testing

A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC

Who this might be right for
Metastatic Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell Carcinoma
Bicara Therapeutics 160
Early research (Phase 1)Looking for participantsNCT07584499
What this trial is testing

Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors

Who this might be right for
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M)Nasopharyngeal CarcinomaLymphoepithelial Carcinoma+7 more
Sun Yat-sen University 51
Next Page